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Role of the Lateral Tegmental Field in the Sympatholytic Action of 5-HT1A Agonists

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Serotonin

Part of the book series: Medical Science Symposia Series ((MSSS,volume 5))

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Abstract

This study was designed to examine the role of the lateral tegmental field (LTF) in the sympatholytic effect of 5-HT1A agonists such as 8-OH-DPAT. Three types of sympathetic-related neurons were identified in the lateral tegmental field of anesthetized cats based on their response to baroreceptor activation (i.e. sympathoexcitatory, sympathoinhibitory,or baroreceptor unresponsive). Intravenous 8-OH-DPAT inhibited sympathoexcitatory neurons with a high degree of correlation to inhibition of sympathetic activity, and excited sympathoinhibitory neurons in a dose-dependent manner. lontophoretic application of 8-OH-DPAT and 5-HT onto sympathoexcitatory neurons caused inhibition of spontaneous activity. Iontophoretic application of 8-OH-DPAT to sympathoinhibitory neurons had variable effects although 5-HT consistently caused excitation. Microinjection of kainic acid into the LTF blocked the sympatholytic effects of 8-OH-DPAT but not that produced by clonidine. These data indicate that 8-OH-DPAT acts in the LTF to inhibit sympathetic nerve activity and therefore lower arterial blood pressure.

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References

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Author information

Authors and Affiliations

  1. The Upjohn Company Kalamazoo, Michigan, 49001, USA

    Robert B. Mccall & Mark E. Clement

Authors
  1. Robert B. Mccall
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  2. Mark E. Clement
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Editor information

Editors and Affiliations

  1. Baylor College of Medicine, Houston, Texas, USA

    P. M. Vanhoutte

  2. Department of Pharmacology, Erasmus University, Rotterdam, The Netherlands

    P. R. Saxena

  3. Institute of Pharmacological Sciences, University of Milan, Milan, Italy

    R. Paoletti

  4. University of Modena, Department of Pharmaceutical Sciences, Modena, Italy

    N. Brunello

  5. Giovanni Lorenzini Medical Foundation, Houston, Texas, USA

    A. S. Jackson (Assistant Editor) (Assistant Editor)

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© 1993 Springer Science+Business Media Dordrecht

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Mccall, R.B., Clement, M.E. (1993). Role of the Lateral Tegmental Field in the Sympatholytic Action of 5-HT1A Agonists. In: Vanhoutte, P.M., Saxena, P.R., Paoletti, R., Brunello, N., Jackson, A.S. (eds) Serotonin. Medical Science Symposia Series, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1920-7_16

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  • DOI: https://doi.org/10.1007/978-94-011-1920-7_16

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  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4849-1

  • Online ISBN: 978-94-011-1920-7

  • eBook Packages: Springer Book Archive

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