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Glomerulonephritis in the elderly

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Nephrology and Urology in the Aged Patient

Part of the book series: Developments in Nephrology ((DINE,volume 34))

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Abstract

Differences in certain immunological markers and their function in the elderly might be expected to translate into a change in the severity or type of glomerulonephritis (‘the elderly’ are those who have attained the age of 60 or more and have biopsy-proven glomerulonephritis). These abnormalities have been noted in both humoral and cell-mediated components of immunity. Alterations in T-cell function include a general reduction in T-helper cell and an increase in T-suppressor cell populations and an increase in anergy as demonstrated by a delayed hypersensitivity reaction to a number of different mitogens [1–3]. In humoral immunity, several workers have observed a decrease in soluble-substance elaboration such as migration-inhibition factor [4, 5]. In both the animal and human species, physical changes with age have been described and include alterations in both the thickness and composition of the glomerular basement membrane [6, 7].

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Authors
  1. Daniel C. Cattran
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Editor information

Editors and Affiliations

  1. University of Toronto, Toronto, Ontario, M5T 2S8, Canada

    Dimitrios G. Oreopoulos M.D., Ph.D., F.R.C.P.C, F.A.C.P. (Professor of Medicine, Director, Peritoneal Dialysis) (Professor of Medicine, Director, Peritoneal Dialysis)

  2. The Toronto Hospital, Toronto, Ontario, M5T 2S8, Canada

    Dimitrios G. Oreopoulos M.D., Ph.D., F.R.C.P.C, F.A.C.P. (Professor of Medicine, Director, Peritoneal Dialysis) (Professor of Medicine, Director, Peritoneal Dialysis)

  3. Department of Medicine, Lenox Hill Hospital, New York, New York, USA

    Michael F. Michelis M.D. (Chief, Nephrology Section, Clinical Associate Professor of Medicine) (Chief, Nephrology Section, Clinical Associate Professor of Medicine)

  4. Cornell University Medical College, New York, New York, 10021, USA

    Michael F. Michelis M.D. (Chief, Nephrology Section, Clinical Associate Professor of Medicine) (Chief, Nephrology Section, Clinical Associate Professor of Medicine)

  5. Urodynamics Unit, Sunnybrook Health Science Centre, Toronto, Ontario, M5N 3M5, Canada

    Sender Herschorn B.Sc., M.D.C.M., F.R.C.S.C. (Chief of Urology, Director, Assistant Professor, Consultant Urologist) (Chief of Urology, Director, Assistant Professor, Consultant Urologist)

  6. Department of Surgery(Urology), University of Toronto, Toronto, Canada

    Sender Herschorn B.Sc., M.D.C.M., F.R.C.S.C. (Chief of Urology, Director, Assistant Professor, Consultant Urologist) (Chief of Urology, Director, Assistant Professor, Consultant Urologist)

  7. Lyndhurst Hospital and Rehabilitation Centre, Toronto, Canada

    Sender Herschorn B.Sc., M.D.C.M., F.R.C.S.C. (Chief of Urology, Director, Assistant Professor, Consultant Urologist) (Chief of Urology, Director, Assistant Professor, Consultant Urologist)

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© 1993 Springer Science+Business Media Dordrecht

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Cattran, D.C. (1993). Glomerulonephritis in the elderly. In: Oreopoulos, D.G., Michelis, M.F., Herschorn, S. (eds) Nephrology and Urology in the Aged Patient. Developments in Nephrology, vol 34. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1822-4_8

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  • DOI: https://doi.org/10.1007/978-94-011-1822-4_8

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4804-0

  • Online ISBN: 978-94-011-1822-4

  • eBook Packages: Springer Book Archive

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