Abstract
The hydrodynamics of Centrifugal Partition Chromatography (CPC), an interesting analytical and preparative scale separation technique, are being investigated for modelling and scale-up. The influences of input variables on hold-up and pressure drop have been measured with an analytical scale CP-chromatograph; a preliminary overview of the first results is given.
It is assumed that a number of flow regimes are possible. The formation of individual droplets of mobile phase in the stationary phase is questionable; it is more likely that jets and bypasses are formed.
The maximal hold-up of the stationary phase in an analytical scale CPC-column is affected by flow rate and centrifugal field; more stationary phase (up to 73 vol. %) can be retained when the rotation frequency is increased, while the stationary phase hold-up gradually decreases with increasing flow rate.
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© 1993 Springer Science+Business Media Dordrecht
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Meester, R., van Buel, M.J., van der Wielen, L.A.M., Verpoorte, R., Luyben, K.C.A.M. (1993). Hydrodynamics of Centrifugal Partition Chromatography. In: Weijnen, M.P.C., Drinkenburg, A.A.H. (eds) Precision Process Technology. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1759-3_22
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DOI: https://doi.org/10.1007/978-94-011-1759-3_22
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