Interleukin-2 and lymphokine activated killer (LAK) cells

  • Sylvie Negrier
  • Thierry O. Philip


Lymphokine-activated-killer cells are peripheral lymphocytes that develop, following exposure to Interleukin-2 (IL2), the ability to lyse tumour cells but not normal cells. This phenomenon has been extensively studied in the early eighties. These LAK cells appeared cytotoxic to non-cultured, natural killer-cell-resistant tumour cells without antigenic stimulation implicating killing in a non MHC-restricted manner [1, 2]. Extensive studies of the precursors of LAK cells have revealed that they are constituted in part of activated cytotoxic T cells but consist predominantly of activated Natural-Killer (NK) cells [3,4].


Clin Oncol Killer Cell Metastatic Renal Cell Carcinoma Activate Killer Cell Adoptive Immunotherapy 
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© Springer Science+Business Media Dordrecht 1993

Authors and Affiliations

  • Sylvie Negrier
  • Thierry O. Philip

There are no affiliations available

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