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High Pressure Chemistry, Biochemistry and Materials Science pp 545–560Cite as

Volumetric Properties of Model Biomembranes

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Part of the book series: NATO ASI Series ((ASIC,volume 401))

Abstract

In this contribution volumetric measurements on dilute aqueous dispersions of the model biomembrane dimyristoylphosphatidylcholine at temperatures ranging from 0 to 90 ¡ãC and at pressures from ambient up to 2500 bar are presented. The thermal expansion coefficient, the isothermal compressibility, and the lipid volume fluctuations of the model membrane in its various thermotropic and barotropic phases and an accurate temperature-pressure phase diagram for the liquid-crystalline to gel phase transformation of the lipid could be obtained from these experiments. In addition to the results of the pure phospholipid system, the influence of the local anaesthetic tetracaine on the thermodynamic properties and the phase behaviour of the membrane is discussed. As tetracaine can be viewed as a model system for amphiphilic molecules, these results provide insight into the general understanding of the physico-chemical action of many amphiphilic molecules on membranes. The biological relevance of these kind of studies is discussed.

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Authors and Affiliations

  1. Ruhr-University of Bochum, Institute of Physical Chemistry, Universitätsstraße, 150, D-4630 Bochum 1, Germany

    R. Winter & M. Böttner

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  1. R. Winter
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  2. M. Böttner
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Editors and Affiliations

  1. Ruhr-University of Bochum, Bochum, Germany

    R. Winter

  2. University of Illinois, School of Chemical Sciences, Urbana, Illinois, USA

    J. Jonas

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© 1993 Springer Science+Business Media Dordrecht

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Winter, R., Böttner, M. (1993). Volumetric Properties of Model Biomembranes. In: Winter, R., Jonas, J. (eds) High Pressure Chemistry, Biochemistry and Materials Science. NATO ASI Series, vol 401. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1699-2_25

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  • DOI: https://doi.org/10.1007/978-94-011-1699-2_25

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4744-9

  • Online ISBN: 978-94-011-1699-2

  • eBook Packages: Springer Book Archive

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