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Autoantibodies to histones, Sm and ubiquitins

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Manual of Biological Markers of Disease

Abstract

There are five histones for packaging DNA: four make a bobbin and the fifth a cleat. Autoantibodies recognising histones are amongst the most abundant in health and disease. They tend to arise with ageing and chronic infection, and as a response to therapy with various drugs. They may occur in rheumathoid arthritis and juvenile chronic arthritis. Titres are almost invariably high in drug induced lupus, and antihistone antibodies are particularly common in systemic lupus erythematosus and autoimmune chronic active (lupoid) hepatitis; they are probably responsible for the LE cell phenomenon.

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Author information

Authors and Affiliations

  1. Rheumatology Department, Stopford Building, The University of Manchester, M13 9PT, UK

    Robert Bernstein

Authors
  1. Robert Bernstein
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Editor information

Editors and Affiliations

  1. University of Nijmegen, The Netherlands

    W. J. van Venrooij

  2. The Mathilda and Terence Kennedy Institute of Rheumatology, London, UK

    R. N. Maini

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© 1996 Kluwer Academic Publishers

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Bernstein, R. (1996). Autoantibodies to histones, Sm and ubiquitins. In: van Venrooij, W.J., Maini, R.N. (eds) Manual of Biological Markers of Disease. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1670-1_39

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  • DOI: https://doi.org/10.1007/978-94-011-1670-1_39

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-0-7923-2219-1

  • Online ISBN: 978-94-011-1670-1

  • eBook Packages: Springer Book Archive

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