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Receptors in the Developing Nervous System pp 21–42Cite as

Muscarinic Receptors and the Developing Nervous System

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Abstract

The cholinergic system plays a primary role in a number of important behaviors, and cholinergic dysfunctions may result in several neurological disorders (e.g. dementias, affective disorders; Singh et al., 1985). In the central nervous system, muscarinic receptors constitute the majority of receptors of the cholinergic type. Though the muscarinic action of acetylcholine has been known since the beginning of the century, a significant advancement in our knowledge of the biochemical and molecular characteristics of muscarinic receptors has occurred only in the last decade. A number of excellent reviews on muscarinic receptors give a comprehensive discussion of the subject (Nathanson, 1987; Mitchelson, 1988; Brown, 1989; Goyal, 1989; Mei et al., 1989; van Delft et al., 1989; Hulme et al., 1990). The most striking findings of the last decade are probably the discovery of the existence of several muscarinic receptor subtypes and the characterization of their second messenger responses.

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  1. Lucio G. Costa
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Costa, L.G. (1993). Muscarinic Receptors and the Developing Nervous System. In: Zagon, I.S., McLaughlin, P.J. (eds) Receptors in the Developing Nervous System. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1544-5_2

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