Abstract
Retroviruses are classified into three families: oncoviruses, which cause cancer, lentiviruses, which cause ‘slow virus disease’; and spumaviruses, which are generally thought not to cause disease. The lentiviruses, which include ovine maedi—visna virus (MVV), caprine arthritis—encephalitis virus (CAEV) and the human and simian immunodeficiency viruses (HIV and SIV), cause chronic inflammatory and degenerative disease of the lungs, brain, joints, mammary glands and lymphoid tissue characterized by insidious onset, slow progression, and variable clinical course 1,2. CAEV was the first lentivirus to be associated with naturally occurring chronic arthritis, and was shown to cause a similar inflammatory joint disease when inoculated experimentally into newborn goats 3. Subsequently, it was found that sheep naturally or experimentally infected with MVV also developed chronic inflammatory arthritis 4,5. More recently, it has become clear that HIV infection is associated with a variety of joint problems 6, and that SIV can induce chronic inflammatory joint disease in both natural and experimental infections in monkeys 7,8. The association with joint disease is not restricted to lentiviruses, but is also found in patients infected with the oncovirus human T-cell leukaemia virus 1 (HTLV-I) 9.
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Harkiss, G.D. (1994). Retroviral Arthritis in Animals and Man. In: Panayi, G.S. (eds) Immunology of the Connective Tissue Diseases. Immunology and Medicine Series, vol 22. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1432-5_12
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