Abstract
Helicobacter pylori therapy can either succeed (cure the infection) or fail. Failure is demonstrated by return of the original infecting organism soon after ending antimicrobial therapy (recrudescence of the infection). Cure of the infection does not guarantee that the individual will not be re-exposed to the bacterium and become reinfected with either the same or a new strain of H. pylori. Discovery of return of infection after a course or courses of antimicrobial therapy can be the result of either reinfection or recrudescence. It is not always easy to distinguish between them.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Borsch GM, Graham DY. Helicobacter pylori. In: Cohen MJ, Benjamin SB, editors. Pharmacology of peptic ulcer disease. Handbook of experimental pharmacology, Vol. 99. Berlin: Springer-Verlag; 1991: 107–48.
Alpert LC, Graham DY, Evans DJ Jr et al. Diagnostic possibilities for Campylobacter pylori infection. Eur J Gastroenterol Hepatol. 1989; 1: 17–26.
Genta RM, Graham DY. Where to biopsy for the histopathologic diagnosis of Helicobacter pylori: a topographic study of H. pylori density and distribution. Gastrointest Endosc. 1993:in press.
Genta RM, Robason GO, Graham DY. Simultaneous visualization of Helicobacter pylori and gastric morphology: a new stain. Hum Pathol. 1993:in press.
Borody T, Andrews P, Mancuso N, Jankiewicz E, Brandi S. Helicobacter pylori reinfection 4 years post-eradication [letter]. Lancet. 1992; 339: 1295.
Veenendaal RA, Peña AS, Meijer JL et al. Long term serological surveillance after treatment of Helicobacter pylori infection. Gut. 1991; 32: 1291–4.
Coelho LG, Passos MC, Chausson Y et al. Duodenal ulcer and eradication of Helicobacter pylori in a developing country. An 18-month follow-up study. Scand J Gastroenterol. 1992; 27: 362–6.
Schutze K, Hentschel E, Brandstatter G. More on the eradication of Helicobacter pylori and the recurrence of duodenal ulcer. N Engl J Med. 1993; 328: 1356.
Morris AJ, Ali MR, Nicholson GI, Perez-Perez GI, Blaser MJ. Long-term follow-up of voluntary ingestion of Helicobacter pylori. Ann Intern Med. 1991; 114: 662–3.
Seppala K, Farkkila M, Nuutinen H et al. Triple therapy of Helicobacter pylori infection in peptic ulcer. A 12-month follow-up study of 93 patients. Scand J Gastroenterol. 1992; 27: 973–6.
Oderda G, Vaira D, Ainley C et al. Eighteen month follow up of Helicobacter pylori positive children treated with amoxycillin and tinidazole. Gut. 1992; 33: 1328–30.
Patchett S, Beattie S, Leen E, Keane C, O’Morain C. Helicobacter pylori and duodenal ulcer recurrence. Am J Gastroenterol. 1992; 87: 24–7.
Culter AF, Schubert TT. Long-term Helicobacter pylori recurrence after successful eradication with triple therapy. Am J Gastroenterol. 1993; 88: 1359–61.
Graham DY. Helicobacter pylori: its epidemiology and its role in duodenal ulcer disease. J Gastroenterol Hepatol. 1991;6:105–13.
Graham DY, Adam E, Klein PD et al. Epidemiology of Campylobacter pylori infection. Gastroenterol Clin Biol. 1989; 13: 84–8B.
Graham DY, Adam E, Reddy GT et al. Seroepidemiology of Helicobacter pylori infection in India. Comparison of developing and developed countries. Dig Dis Sci. 1991; 36: 1084–8.
Graham DY, Alpert LC, Smith JL, Yoshimura HH. Iatrogenic Campylobacter pylori infection is a cause of epidemic achlorhydria. Am J Gastroenterol. 1988; 83: 974–80.
Langenberg W, Rauws EA, Oudbier JH, Tytgat GN. Patient-to-patient transmission of Campylobacter pylori infection by fiberoptic gastroduodenoscopy and biopsy. J. Infect Dis. 1990; 161: 507–11.
Klein PD, Graham DY, Gaillour A, Opekun AR, Smith EO. Water source as risk factor of Helicobacter pylori infection in Peruvian children. Gastrointestinal Physiology Working Group. Lancet. 1991; 337: 1503–6.
Drumm B, Perez-Perez GI, Blaser MJ, Sherman PM. Intrafamilial clustering of Helicobacter pylori infection. N Engl J Med. 1990; 322: 359–63.
Mitchell HM, Bohane TD, Berkowicz J, Hazell SL, Lee A. Antibody to Campylobacter pylori in families of index children with gastrointestinal illness due to C. pylori [letter]. Lancet. 1987; 2: 681–2.
Oderda G, Vaira D, Holton J et al. Helicobacter pylori in children with peptic ulcer and their families. Dig Dis Sci. 1991; 36: 572–6.
Malaty HM, Graham DY, Klein PD, Evans DG, Adam E, Evans DJ. Transmission of Helicobacter pylori infection. Studies in families of healthy individuals. Scand J Gastroenterol. 1991; 26: 927–32.
Graham DY, Klein PD, Evans DG et al. Helicobacter pylori: epidemiology, relationship to gastric cancer and the role of infants in transmission. Eur J Gastroenterol Hepatol. 1992; 4 (Suppl. 1): S1–6.
Morgan DR, Costas M, Owen RJ, Williams EA. Characterization of strains of Helicobacter pylori: one-dimensional SDS-PAGE as a molecular epidemiologic tool. Rev Infect Dis. 1991; 13 (Suppl. 8): S709–13.
Langenberg W, Rauws EA, Widjojokusumo A, Tytgat GN, Zanen HC. Identification of Campylobacter pyloridis isolates by restriction endonuclease DNA analysis. J Clin Microbiol. 1986; 24: 414–17.
Go MF, Chan KY, Versalovic J, Koeuth T, Graham DY, Lupski JR. DNA fingerprinting of H. pylori genomes with repetitive DNA sequence-based PCR (REP-PCR). Gastroenterology. 1993; 104: A2401 (abstract).
Akopyanz N, Bukanov NO, Westblom TU, Berg DE. PCR-based RFLP analysis of DNA sequence diversity in the gastric pathogen Helicobacter pylori. Nucl Acids Res. 1992; 20: 6221–5.
Foxall PA, Hu LT, Mobley HL. Use of polymerase chain reaction-amplified Helicobacter pylori urease structural genes for differentiation of isolates. J Clin Microbiol. 1992; 30: 739–41.
Lopez CR, Owen RJ, Desai M. Differentiation between isolates of Helicobacter pylori by PCR-RFLP analysis of urease A and B genes and comparison with ribosomal RNA gene patterns. FEMS Microbiol Lett. 1993; 110: 37–43.
Clayton CL, Kleanthous H, Morgan DD, Puckey L, Tabaqchali S. Rapid fingerprinting of Helicobacter pylori by polymerase chain reaction and restriction fragment length polymorphism analysis. J Clin Microbiol. 1993; 31: 1420–5.
Tee W, Lambert J, Smallwood R, Schembri M, Ross BC, Dwyer B. Ribotyping of Helicobacter pylori from clinical specimens. J Clin Microbiol. 1992; 30: 1562–7.
Malaty HM, Engstrand L, Pederson N, Graham DY. Is there a genetic influence in Helicobacter pylori susceptibility and transmission: the twin study. Am J Gastroenterol. 1992; 399: 1342 (abstract).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1994 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Graham, D.Y., Genta, R.M. (1994). Reinfection with H. pylori . In: Hunt, R.H., Tytgat, G.N.J. (eds) Helicobacter pylori. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1418-9_8
Download citation
DOI: https://doi.org/10.1007/978-94-011-1418-9_8
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-4620-6
Online ISBN: 978-94-011-1418-9
eBook Packages: Springer Book Archive