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Rabbit Models in Genetic Research in Atherosclerosis

  • Chapter
Book cover Genetic factors in coronary heart disease

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 156))

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Abstract

The familial aggregation of coronary heart disease is well recognized. Nora et al. analysed risk factors for coronary heart disease in 207 patients with myocardial infarction1. They observed that, for patients under 55 years of age, the highest risk, among 19 risk indices of coronary heart disease, was associated with a positive familial history of the disease. The risk associated with the latter was far higher than the effects of blood cholesterol, smoking, diabetes and other factors which influence the development of the disease. Although there are many reports about the heritability of atherosclerosis in humans, including reports on monozygotic and dizygotic twins, a thorough examination of the effects of unknown factors, including lifestyle, environmental and other factors, is required in these studies.

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Authors and Affiliations

  1. Institute for Experimental Animals, Kobe University School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650, Japan

    Masashi Shiomi & Yoshio Watanabe

Authors
  1. Masashi Shiomi
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  2. Yoshio Watanabe
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Editor information

Editors and Affiliations

  1. Sackler Medical Faculty, Epidemiology and Biostatistics, the Neufeld Cardiac Research Institute, Sheba Medical Center and Tel Aviv University, Israel

    Uri Goldbourt (Professor of Epidemiology and Preventive Medicine, Head) (Professor of Epidemiology and Preventive Medicine, Head)

  2. Division of Epidemiology, Institute of Environmental Medicine, Karolinska Institute and Division of Cardiovascular Medicine, Department of Internal Medicine, Karolinska Hospital, Stockholm, Sweden

    Ulf de Faire (Professor) (Professor)

  3. Institute of Medical Genetics, Department of Medical Genetics, Ullevål University Hospital, Oslo, Norway

    Kåre Berg (Professor of Medicine, Chairman, Director and Physician-in-Chief) (Professor of Medicine, Chairman, Director and Physician-in-Chief)

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© 1994 Springer Science+Business Media Dordrecht

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Shiomi, M., Watanabe, Y. (1994). Rabbit Models in Genetic Research in Atherosclerosis. In: Goldbourt, U., de Faire, U., Berg, K. (eds) Genetic factors in coronary heart disease. Developments in Cardiovascular Medicine, vol 156. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1130-0_8

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  • DOI: https://doi.org/10.1007/978-94-011-1130-0_8

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4494-3

  • Online ISBN: 978-94-011-1130-0

  • eBook Packages: Springer Book Archive

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