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Autonomic nervous system and large conduit arteries

  • Gérard M. London
  • Michel E. Safar
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 144)

Abstract

The vessels have the ability to alter their caliber and to influence the regional vascular resistance and capacitance through the modification of the neuronal discharge or changes in circulating catecholamines. Several in vitro studies demonstrated the extreme diversity of responses in the control of vascular tone of large conduit arteries and smaller resistive vessels [1], resulting from differences in the response to adrenoreceptor stimulation and antagonism between large and small arteries. Firstly, aorta and large conduit arteries which contain highly sensitive vascular smooth muscle cells have an excess of alpha1-adrenoreceptors, and are quite sensitive to adrenergic stimulation [2, 3]. Second, abrupt decrease in responsiveness to catecholamines occurs close to the roots of many aortic branches, and continue to fall-off as the arteries get smaller and further divide [4]. Finally, the sympathetic control of vascular tone of large arteries is more sensitive to alpha-adrenergic blockade, than that of smaller vessels [5].

Keywords

Brachial Artery Large Artery Blood Velocity Transmural Pressure Cold Pressor Test 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 1993

Authors and Affiliations

  • Gérard M. London
  • Michel E. Safar

There are no affiliations available

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