Preemptive Analgesia

  • H. Kehlet
  • J. B. Dahl
Part of the Developments in Critical Care Medicine and Anesthesiology book series (DCCA, volume 29)


Experimental studies in animals have demonstrated tissue injury or noxious stimulation results in long-term functional changes in the central nervous system, with expansion of receptive fields, facilitation of flexor motor neuronal responses and decrease in the threshold of dorsal horn neurons (1–4). Experience from clinical studies following capsaicin stimulation (5,6), thermal injury (7,8), or gynecological laparotomy (9) suggests similar post-injury changes to take place in humans. Consequently, it has been suggested that surgery may lead to spinal cord hyperexcitability, which may amplify and/or prolong postoperative pain (10).


Postoperative Pain Opioid Requirement Preemptive Analgesia Secondary Hyperalgesia Neural Blockade 
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© Springer Science+Business Media Dordrecht 1994

Authors and Affiliations

  • H. Kehlet
  • J. B. Dahl

There are no affiliations available

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