Abstract
In vitro culturing of graft infiltrating lymphocytes has been useful in studying cell-mediated mechanisms of transplant immunity [1]. These cultures are generated in the presence of Interleukin-2 (IL-2) which induces proliferation of activated T lymphocytes expressing IL-2 receptors. In heart transplant patients, lymphocyte growth from endomyocardial biopsies correlates with the rejection grade assessed by histology [2]. During the first month after transplantation, about one-third of histologically negative biopsies show lymphocyte growth and this is associated with a higher incidence and earlier onset of a subsequent rejection episode [3,4]. During the first three months after transplantation, lymphocyte growth is also associated with a higher incidence of graft coronary disease [5].
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References
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© 1994 Springer Science+Business Media Dordrecht
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Duquesnoy, R.J., Moliterno, R., Chen-Woan, M., Kaufman, C., Zerbe, T.R., Zeevi, A. (1994). Characterizaton of Graft Infiltrating Lymphocytes Involved in Cardiac Transplant Rejection. In: Touraine, J.L., Traeger, J., BĂ©tuel, H., Dubernard, J.M., Revillard, J.P., Dupuy, C. (eds) Rejection and Tolerance. Transplantation and Clinical Immunology, vol 25. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0802-7_9
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DOI: https://doi.org/10.1007/978-94-011-0802-7_9
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