Skip to main content
SpringerLink
Log in
Book cover

Rejection and Tolerance pp 65–70Cite as

Xenotransplantation: The Current Status of Understanding

  • Chapter

Part of the book series: Transplantation and Clinical Immunology ((TRAC,volume 25))

Abstract

Xenoreactive natural antibodies (XNA) present in the blood of all individuals and reactive with antigens on cells of phylogenetically widely-separated species, as well as complement (C) play major roles in initiating hyperacute rejection (HAR) of a discordant xenograft. Depletion of either of these entities appears to result in prolongation of graft survival [1–4].

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bach FH, Platt JL, Cooper D. Accommodation: the role of natural antibody and complement in discordant xenograft rejection. In: Cooper D, Kemp E, Reemtsma K, White DJG, editors. Xenotransplantation-the transplantation of organs and tissues between species. Heidelberg, Germany: Springer-Verlag. 1991:81–100.

    Google Scholar 

  2. Blakely ML, Van der Werf WJ, Hancock WW, Bach FH. Prolonged suppression of xenoreactive natural antibodies and elimination of hyperacute rejection in a discordant xenotransplant model. Transplantation, submitted.

    Google Scholar 

  3. Pruitt SK, Baldwin WM, Marsh HC, Lin SS, Yeh CG, Bollinger RR. The Effect of soluble complement receptor type 1 on hyperacute xenograft rejection. Transplantation 1991;52:868–873.

    Article  PubMed  CAS  Google Scholar 

  4. Bach FH, Van der Werf WJ, Blakely ML, Vanhove B, de Martin R, Winkler H. Discordant Xenografting: A Working model of problems and issues. Xeno, in press.

    Google Scholar 

  5. Platt JL, Bach FH. Mechanisms of tissue injury in hyperacute xenograft rejection. In: Cooper DKC, Kemp E, Reemtsma K, and White DJG, editors. Xenotransplantation, 1990.

    Google Scholar 

  6. Vanhove B, Bach FH. Human xenoreactive natural antibodies: avidity and targets on porcine endothelial cells. Transplantation, in press.

    Google Scholar 

  7. Platt JL, Lindman BJ, Geller RL, et al. The role of natural antibodies in the activation of xenogeneic endothelial cells. Transplantation 1991;52:1037–1043.

    Article  PubMed  CAS  Google Scholar 

  8. Figueroa J, Fuad SA, Kunjummen BD, Platt JL, Bach FH. Suppression of synthesis of natural antibodies by mycophenolate mofetil (RS-61443). Transplantation 1993;55:1371–1374.

    Article  PubMed  CAS  Google Scholar 

  9. Leventhal J, Flores H, Gruber S, et al. III: Natural antibody production can be inhibited by 15-Deoxyspergualin in a discordant xenograft model. Transplantation Proc 1992;24:714.

    Google Scholar 

  10. Blakely ML, Van der Werf WJ, Hancock WW, Bach FH. Prolonged suppression of xenoreactive natural antibodies and elimination of hyperacute rejection in a discordant xenotransplantation model. (Submitted)

    Google Scholar 

  11. Soares MP, Latirme D, Elsen M, Figueroa J, Bach FH, Bazin H. In vivo depletion of xenoreactive natural antibodies with an anti-μ monoclonal antibody. Transplantation, in press.

    Google Scholar 

  12. Platt JL, Lindman BJ, Chen H, Spitalnik SL, Bach FH. Endothelial cell antigens recognized by xenoreactive human natural antibodies. Transplantation 1990;50:817–822.

    Article  PubMed  CAS  Google Scholar 

  13. Hofer-Warbinek R, et al. Unpublished observations.

    Google Scholar 

  14. Hebell T, Ahearn JM, Fearon DT. Suppression of the immune response by a soluble complement receptor of B lymphocytes. Science 1991;254(5028):102.

    Article  PubMed  CAS  Google Scholar 

  15. Dalmasso AP, Vercellotti GM, Platt JL, Bach FH. Inhibition of complement-mediated endothelial cell cytotoxicity by decay accelerating factor: Potential for prevention of xenograft hyperacute rejection. Transplantation 1991;52:530.

    Article  PubMed  CAS  Google Scholar 

  16. Bach FH, Turman MA, Vercellotti GM, Platt JL, Dalmasso AP. Accommodation: A working paradigm for progressing toward clinical discordant xenografting. Transpl Proc 1991;23:205.

    CAS  Google Scholar 

  17. White DJ, Oglesby T, Liszewski MK, et al. Expression of human decay accelerating factor or membrane cofactor protein genes on mouse cells inhibits lysis by human complement. Transpl Proc 1992;24(2):474.

    CAS  Google Scholar 

  18. Bach FH, Dalmasso G, Platt JL. Xenotransplantation: A current perspective. Transplantation Reviews 1992;6:1–7.

    Article  Google Scholar 

  19. Hofer E, et al. Unpublished observations.

    Google Scholar 

  20. Vanhove B, Lipp J, de Martin R, Bach FH. Affinity purified human xenoreactive natural antibodies deliver an activating signal to pig endothelial cells. In preparation.

    Google Scholar 

  21. Alexandre GPJ, Latinne D, Gianello P, Squifflet JP. Preformed cytotoxic antibodies and ABO-incompatible grafts. Clin Transplantation 1991;(Spec. issue) 5: 583–594.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Sandoz Center for Immunobiology, Harvard Medical School, 185 Pilgrim Road, Boston, MA, 02215, USA

    Fritz H. Bach MD, Willem J. Van der Werf MD, Martin L. Blakely MD, Bernard Vanhove PhD, Rainer de Martin PhD & Hans Winkler PhD

Authors
  1. Fritz H. Bach MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Willem J. Van der Werf MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Martin L. Blakely MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Bernard Vanhove PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Rainer de Martin PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hans Winkler PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

J. L. Touraine J. Traeger H. Bétuel J. M. Dubernard J. P. Revillard C. Dupuy

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Bach, F.H., Van der Werf, W.J., Blakely, M.L., Vanhove, B., de Martin, R., Winkler, H. (1994). Xenotransplantation: The Current Status of Understanding. In: Touraine, J.L., Traeger, J., Bétuel, H., Dubernard, J.M., Revillard, J.P., Dupuy, C. (eds) Rejection and Tolerance. Transplantation and Clinical Immunology, vol 25. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0802-7_6

Download citation

  • DOI: https://doi.org/10.1007/978-94-011-0802-7_6

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4345-8

  • Online ISBN: 978-94-011-0802-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation