Abstract
The functions of T lymphocyte sub-populations in allograft rejection have been extensively studied in animal models of kidney transplantation, but in most instances, their roles have not been analysed in immunosuppressed animals. One of the interesting features of successful clinical renal transplants in immunosuppressed human patients is that rejection becomes less frequent and less acutely destructive with passage of time. Because of this, immunosuppression can be safely tapered to levels that still prevent rejection, but also avoid most, though not all, the toxic side effects of drug therapy. The explanation of this changing pattern of rejection remains unknown in cellular and molecular terms.
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© 1994 Springer Science+Business Media Dordrecht
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Batchelor, J.R., Braun, M.Y. (1994). Distinct T Cells Mediating Acute and Chronic Rejection. In: Touraine, J.L., Traeger, J., Bétuel, H., Dubernard, J.M., Revillard, J.P., Dupuy, C. (eds) Rejection and Tolerance. Transplantation and Clinical Immunology, vol 25. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0802-7_10
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DOI: https://doi.org/10.1007/978-94-011-0802-7_10
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-4345-8
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