Abstract
In 1961 reports started to appear of heavy losses in turkey poults and ducklings during the previous year. In the United Kingdom, 100 000 birds were reported to have died in approximately 500 outbreaks of what was named Turkey X disease. Infected birds showed characteristic histological lesions in the liver, which were initially thought to be related to seneciosis in fowls (Siller and Ostler, 1961). The common factor in the UK outbreaks was a diet containing 10% of certain consignments of Brazilian groundnut meal (Blount, 1961). During the same year a similar condition was reported in ducklings in Kenya and was traced to locally grown expeller-processed groundnut meal (Asplin and Carnaghan, 1961). Indian groundnut meal, making up 6% of a diet, was linked to more deaths in the following year (Carnaghan and Sargeant, 1961). Also in 1961, a toxic factor was extracted with chloroform from the Brazilian meal (Allcroft et al., 1961) and was shown to be extremely toxic for young ducklings, producing lesions histologically identical to those in Turkey X disease (Asplin and Carnaghan, 1961). It was also shown to be free from plant alkaloids (Sargeant et al., 1961a). Toxicity testing of the Indian meal (Carnaghan and Sargeant, 1961) produced liver lesions identical to those produced by the Brazilian and East African toxic meals, though the toxicity of these samples was considerably less.
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References
Abalaka, J.A. and Elegbede, J.A. (1982) Aflatoxin distribution and total microbial counts in an edible oil extracting plant. I. Preliminary observations. Food and Chemical Toxicology, 20, 43–46.
Aibara, K., Ichinoe, M., Maeda, K. et al. (1985) Storage conditions of imported raw shelled peanuts and production of aflatoxins. Journal of the Food Hygienic Society of Japan, 26(3), 234–242.
Akano, D.A. and Atanda, O.O. (1990) The present level of aflatoxin in Nigerian groundnut cake (‘Kulikuli’). Letters in Applied Microbiology, 10, 187–189.
Allcroft, R., Carnaghan, R.B. and Sargeant, K. (1961) A toxic factor in Brazilian groundnut meal. Veterinary Record, 73, 428–429.
Allcroft, R. and Carnaghan, R.B.A. (1962) Groundnut toxicity, Aspergillus flavus toxin in animal products. Veterinary Record, 74, 863–864.
Allcroft, R. and Carnaghan, R.B.A. (1963) Toxic Products in Groundnuts: Biological effects. Chemistry and Industry, 12 January, 1963, pp. 50–53.
Allcroft, R. and Raymond, W.P. (1966) Toxic groundnut meal: biological and chemical assays of a large batch of a ‘reference’ meal used for experimental work. Veterinary Record, 79, 122–123.
Allcroft, R. and Roberts, B.A. (1968) Toxic groundnut meal: the relationship between aflatoxin B1 intake by cows and excretion of aflatoxin M1 in milk. Veterinary Record, 82, 116–118.
Amla, I., Shyamla, Y., Sreenivasamurthy, V. et al. (1970) Role of aflatoxin in Indian childhood cirrhosis. Indian Paediatrics, 7, 262–270.
Amla, I., Kamala, C.S., Gopalakrishna, G.S. et al. (1971) Cirrhosis in children from peanut meal contaminated by aflatoxin. American Journal of Clinical Nutrition, 24, 609–614.
Angsubhakorn, S., Get-Ngern, P., Miyamoto, M. and Bhamarapravati, N. (1990) A single dose-response effect of aflatoxin B1 on rapid liver cancer induction in two strains of rats. International Journal of Cancer, 46, 664–668.
Annau, E., Corner, A.H., Magwood, S.E. and Jericho, K. (1964) Electrophoretic and Chemical Studies on Sera of Swine Following the Feeding of Toxic Groundnut Meal. Canadian Journal of Comparative Medicine and Veterinary Science, 28, 264–269.
Anon. (1984) Aflatoxins and kwashiorkor. Lancet, 2, 1133–1134.
AOAC (1984) Official Methods of Analysis, 14th edn, Association of Official Analytical Chemists, Washington DC.
Asplin, F.D. and Carnaghan, R.B.A. (1961) The toxicity of certain groundnut meals for poultry with special reference to their effect on ducklings and chickens. Veterinary Record, 73, 1215–1219.
Austwick, P.K.C. and Ayerst, G. (1963) Toxic Products in Groundnuts: Groundnut Microflora and Toxicity. Chemistry and Industry, January 12, 1963, 55–61.
Autrup, H., Seremet, T., Wakhisi, J. and Wasunna, A. (1987) Aflatoxin exposure measured by urinary excretion of aflatoxin B1-guanine adduct and hepatitis B virus infection in areas with different liver cancer incidence in Kenya. Cancer Research, 47, 3430–3433.
Azaizeh, H.A., Pettit, R.E., Sarr, B.A. and Phillips, T.D. (1990) Effect of peanut tannin extracts on growth of Aspergillus parasiticus and aflatoxin production. Mycopathologia, 110(3), 125–132.
Basappa, S.C. and Sreenivasamurthy, V.S. (1977) State of aflatoxin in groundnut oil. Journal of Food Science and Technology, 14(2), 57–60.
Baur, F.J. (1975) Effect of storage upon aflatoxin levels in peanut materials. Journal of the American Oil Chemists’ Society, 52(8), 263–265.
Becroft, D.M.O. and Webster, D.R. (1972) Aflatoxins and Reye’s Disease. British Medical Journal, 4, 117.
Beljaars, P.R., Fabry, F.H.M., Pickott, M.M.A. and Peeters, M.J. (1972) Quantitative fluorodensitometric measurement of aflatoxin B1 with a flying-spot densitometer. (2) Comparative study of B1 measurement in spiked and naturally contaminated peanut products. Journal of Association of Official Analytical Chemists, 55(6), 1310–1315.
Beljaars, P.R., Verhulsdonk, C.A.H., Paulsch, W.E., and Liem, D.H. (1973) Collaborative study of two-dimensional thin layer chromatographic analysis of aflatoxin B1 in peanut butter extracts, using the antidiagonal spot application technique. Journal of the Association of Analytical Chemists, 56(6), 1444–1451.
Bennett, R.A., Essigmann, J.M. and Wogan, G.N. (1981) Excretion of an aflatoxin-guanine adduct in urine of aflatoxin B1-treated rats. Cancer Research, 41, 650–654.
Bhat, R.V. (1989) Risk to human health associated with consumption of groundnuts contaminated with aflatoxins, in Aflatoxin contamination of groundnut: Proceedings of the International Workshop, 6–9 Oct 1987, ICRISAT, Patancheru, pp. 19–30.
Blankenship, P.D., Cole, R.J., Sanders, T.H. and Hill, R.A. (1984) Effect of geocarposphere temperature on pre-harvest colonization of drought-stressed peanuts by Aspergillus flavus and subsequent aflatoxin contamination. Mycopathologia, 85, 69–74.
Blount, W.P. (1961) Turkey “X” Disease. Journal of the British Turkey Federation, 9(2), 52–58, 61, 77.
Brown, G.H. (1984) The distribution of total aflatoxin levels in composited samples of peanuts. Food Technology in Australia, 36(3),128–130.
Brudzynski, A., Pee, W. van and Kornaszewski, W. (1978) The occurrence of aflatoxin B1 in peanuts, corn, and dried cassava sold at the local market in Kinshasa, Zaire; its coincidence with high hepatoma morbidity among the population. Food Science and Technology Abstracts, 10 12 C, 492.
Bushnell, D.G. (1965) The incidence of aflatoxin in the Rhodesian groundnut crop. Rhodesia Agricultural Journal, 62, 94–96, 98.
Butler, W.H. and Barnes, J.M. (1968) Carcinogenic Action of Groundnut Meal Containing Aflatoxin in Rats. Food and Cosmetics Toxicology, 6,135–141.
Campbell, T.C., Caedo, J.P.(Jr.), Bulatao-Jayne, J. et al. (1970) Aflatoxin M1 in human urine. Nature, 227, 403–404.
Campbell, T.C., Chen, J., Liu, C. et al. (1990) Nonassociation of aflatoxin with primary liver cancer in a cross-sectional ecological survey in the People’s Republic of China. Cancer Research, 50, 6882–6893.
Carnaghan, R.B.A. and Sargeant, K. (1961) The toxicity of certain groundnut meals to poultry. Veterinary Record, 73, 726–727.
Carnaghan, R.B.A. (1967) Hepatic tumours and other chronic liver changes in rats following a single oral administration of aflatoxin. British Journal of Cancer, 21, 811–814.
Chandra, R.K. (1970) Immunological picture in Indian childhood cirrhosis. Lancet, 1, 537–540.
Chang-Yen, I and Felmine, J. (1987), Aflatoxin levels in selected bulk foods and feeds in Trinidad. Tropical Agriculture (Trinidad), 64(4), 283–286.
Chiou, R.Y.Y., Lin, C.M. and Shyu, S.L. (1990) Property characterization of peanut kernels subjected to gamma irradiation and its effect on the outgrowth and aflatoxin production by Aspergillus parasiticus. Journal of Food Science, 55, 210–213.
Chu, J.S., Lee, R.C., Trucksess, M.W. and Park, D.L. (1988) Evaluation by enzyme-linked immunosorbent assay of cleanup for thin-layer chromatography of aflatoxin B1 in corn, peanuts and peanut butter. Journal of the Association of Official Analytical Chemists, 71(5), 953–956.
Coady, A. (1976) Tropical cirrhosis and hepatoma. Journal of the Royal College of Physicians, 10, 133–144.
Codifer, L.P. Jr., Mann, G.E. and Dollear, F.G. (1976) Aflatoxin inactivation: treatment of peanut meal with formaldehyde and calcium hydroxide. Journal of the American Oil Chemists’ Society, 53(5), 204–206.
Coffey, M.T., Hagler, W.M. Jnr. and Cullen, J.M. (1989) Influence of Dietary Protein, Fat or Amino Acids on the Response of Weanling Swine to Aflatoxin B1 Journal of Animal Science, 67, 465–172.
Coker, R.D. (1979) Aflatoxin: past, present and future. Tropical Science, 21(3),143–162.
Cole, R.J. (1989) Preharvest aflatoxin in peanuts. International Biodeterioration, 25, 253–257.
Cole, D.L. and Masuka, A.J. (1989) Evaluation of New Rapid Methods for Aflatoxin Detection in Groundnuts in Zimbabwe. ICRISAT Proceedings of the Third Regional Groundnut Workshop for Southern Africa, 13–18 March 1988, Lilongwe, Malawi, pp. 185–189.
Cole, R.J., Sanders, T.H., Hill, R.A. and Blankenship, P.D. (1985) Mean geocarposphere temperatures that induce preharvest aflatoxin contamination of peanuts under drought stress. Mycopathologia, 91, 41–16.
Cole, R.J., Hill, R.A., Blankenship, P.D. and Sanders, T.H. (1986a) Color mutants of Aspergillus flavus and Aspergillus parasiticus in a study of preharvest invasion of peanuts. Applied and Environmental Microbiology, 52(5), 1128–1131.
Cole, R.J., Sanders, T.H., Blankenship, P.D. and Hill, R.A. (1986b) Environmental conditions required to induce preharvest aflatoxin contamination of peanuts. Biodeterioration 6. 6th International Biodeterioration Symposium, Washington, DC, August 1984 (eds S. Barry, D.R. Houghton) pp. 294–299.
Coomes, T.J., Crowther, P.C., Feuell, A.J. and Francis, B.J. (1966) Experimental detoxification of groundnut meals containing aflatoxin. Nature, 209, 406–407.
Coon, F.B., Baur, F.J. and Symmes, L.R.L. (1972) International aflatoxin check sample program: 1971 study. Journal of the Association of Official Analytical Chemists, 55(2), 315–327.
Cucullu, A.F., Lee, L.S., Mayne, R.Y. and Goldblatt, L.A. (1966) Determination of Aflatoxins in Individual Peanuts and Peanut Sections. Journal of the American Oil Chemists’ Society, 43, 89–92.
Cullen, J.M., Ruebner, B.H., Hsieh, L.S. et al. (1987) Carcinogenicity of dietary Aflatoxin M1 in male Fischer rats compared to Aflatoxin B1 Cancer Research, 47, 1913–1917.
Davis, N.D., Guy, M.L. and Diener, U.L.. (1980) A fluorometric rapid screen method for aflatoxin in peanuts. Journal of the American Oil Chemists’ Society, 57(3), 109–110.
de Iongh, H., Vies, R.O. and van Pelt, J.G. (1964) Milk of mammals fed on aflatoxin-containing diet. Nature, 202, 466–467.
Delort-Laval, J., Viroben, G. and Borgida, L.P. (1980) Efficacité biologique pour le poulet de chair du tourteau d’arachide traité à l’ammoniac ou à la monométhylamine en vue de l’inactivation des aflatoxines. Annales de Zootechnie, 29(4), 387–400.
Denning, D.W. (1987) Aflatoxin and human disease. Adverse Drug Reaction and Acute Poisoning Reviews, 4, 175–209.
Denning, D.W., Allen, R., Wilkinson, A.P. and Morgan, M.R.A. (1990) Transplacental transfer of aflatoxin in humans. Carcinogenesis, 11(6), 1033–1035.
de Vries, H.R., Maxwell, S.M. and Hendrickse, R.G. (1990) Aflatoxin excretion in children with kwashiorkor or marasmic kwashiorkor — a clinical investigation. Mycopathologia, 110, 1–9.
Dichter, C.R. (1984) Risk estimates of liver cancer due to aflatoxin exposure from peanuts and peanut products. Food and Chemical Toxicology, 22(6), 431–437.
Dickens, J.W. and Weltz, R.E. (1968) Detecting Farmers’ Stock Peanuts containing Aflatoxin by Examination for Visible Growth of Aspergillus flavus. Mycopathologia, 37, 65–69.
Dickens, J.W. and Whitaker, T.B. (1983) Dilution errors in aflatoxin determinations caused by compounds extracted from peanuts. Journal of the Association of Official Analytical Chemists, 66(5), 1059–1062.
Diener, U.L. and Davis, N.D. (1968) Effect of environment on aflatoxin production in freshly dug peanuts. Tropical Science, 10, 22–28.
DiProssimo, V.P. (1976) Distribution of aflatoxins in some samples of peanuts. Journal of the Association of Official Analytical Chemists, 59(4), 941–944.
Dollear, F.G., Mann, G.E., Codifer, Jr., L.P. et al. (1968) Elimination of aflatoxins from peanut meal. Journal of the American Oil Chemists’ Society, 45, 862–865.
Dorner, J.W. and Cole, R.J. (1988) Rapid determination of aflatoxins in raw peanuts by liquid chromatography with postcolumn iodination and modified minicolumn cleanup. Journal of the Association of Official Analytical Chemists, 71(1), 43–47.
Dorner, J.W., Cole, R.J., Sanders, T.H. and Blankenship, P.D. (1989) Interrelationship of kernel water activity, soil temperature, maturity, and phytoalexin production in preharvest aflatoxin contamination of drought-stressed peanuts. Mycopathologia, 105(5), 117–128.
Dorner, J.E. and Cole, R.J. (1989) Comparison of two ELISA screening tests with liquid chromatography for determination of aflatoxins in raw peanuts. Journal of the Association of Official Analytical Chemists, 72(6), 962–964.
Duthie, C.F., Lancaster, M.C., Taylor, J. et al. (1966) Toxic groundnut meal in feeds for pigs. (1) A trial made at two laboratories with pigs from about 40 to 200 lb. live weight fed to a restricted scale. The Veterinary Record, 79(22), 621–625.
Duthie, I.F., Lancaster, M.C., Taylor, J. et al. (1968) Toxic groundnut meal in feeds for pigs. (2) The effect of consuming toxic groundnut meal during part of the growing period or during the finishing period. Veterinary Record, 82, 427–130.
Dwarakanath, C.T., Sreenivusamurthy, V. and Parpia, A.B. (1969) Aflatoxin in Indian peanut oil. Journal of Food Science and Technology, 6, 107–109.
Essigmann, J.M., Croy, R.G., Bennett, R.A. and Wogan, G.N. (1982) Metabolic activation of aflatoxin B1: patterns of DNA Adduct Formation. Removal, and Excretion in Relation to Carcinogenesis. Drug Metabolism Reviews, 13(4), 581–602.
Fehr, P.M., Bernage, L. and Vassilopoulos, V. (1968) Effet de la consommation de tourteau d’arachide pollué par Aspergillus flavus chez le ruminant en lactation. Mémoires Originaux, 377–390.
Ferrando, R., Palisse-Roussel, M. and Jacquot, L. (1984) Relay toxicology of aflatoxin M1 in dried milk. Comptes Rendus Hebdomadaires des Séances Série III Sciences de la Vie, 298(13), 355–358.
Feuell, A.J. (1966) Aflatoxin in groundnuts. Part IX — Problems of detoxification. Tropical Science, 8, 61–70.
Fong, L.Y.Y., Ton, C.C.T., Koonanuwatchaidet, P. and Huang, D.P. (1980) Mutagenicity of peanut oils and effect of repeated cooking. Food and Cosmetic Toxicology, 18, 467-70.
Fong, L.Y.Y, and Chan, W.C. (1981) Long-Term effects of Feeding Aflatoxin-contaminated Market Peanut Oil to Sprague-Dawley Rats. Food and Cosmetic Toxicology, 19, 179–183.
Frayssinet, C. and Lafarge-Frayssinet, C. (1990) Effect of ammoniation on the carcinogenicity of aflatoxin-contaminated groundnut oil cakes: long-term feeding study in the rat. Food Additives and Contaminants, 7(1), 63–68.
Fukal, L., Prosek, J. and Sova, Z. (1987) The occurrence of aflatoxins in peanuts imported into Czechoslovakia for human consumption. Food Additives and Contaminants, 4(3), 285–289.
Gardiner, E.E. (1962) A comparison of the toxicity to poults and chicks of a certain peanut oil meal. Poultry Science, 41, 1348–1350.
Gardner, H.K. Jnr, Koltun, S.P. and Vix, H.L.E. (1968) Solvent extraction of aflatoxins from oilseed meals. Journal of Agriculture and Food Chemistry, 16(6), 990–993.
Gardner, H.K. Jnr, Koltun, S.P., Dollear, F.G. and Rayner, E.T. (1971) Inactivation of Aflatoxins in Peanut and Cottonseed Meals by Ammoniation. Journal of the American Oil Chemists’ Society, 41, 70–73.
Gelda, C.S. and Luyt, L.J. (1977) Survey of total aflatoxin content in peanuts, peanut butter and other foodstuffs. Annals of Nutrition and Metabolism, 31, 477-83.
Glen-Bott, A.M. (1987) Aspirin and Reye’s Syndrome. A Reappraisal. Medical Toxicology, 2, 161–165.
Goldblatt, A. (1971) Control and Removal of Aflatoxin. Journal of the American Oil Chemists’ Society, 41, 605–610.
Golden, M.H.N, and Golden, B.E. (1981) Trace elements. British Medical Bulletin, 37, 32–34.
Groopman, J.D., Donahue, P.R., Zhu, J. et al. (1985) Aflatoxin metabolism in humans: detection of metabolites and nucleic acid adducts in urine by affinity chromatography. Proceeding of the National Academy of Science, 82, 6492–6496.
Groopman, J.D., Donahue, P.R., Zhu, J. et al. (1987) Temporal patterns of aflatoxin metabolites in urine of people living in Guangxi Province, PRC. Proceedings of the American Association of Cancer Research, 28, 130, Abstract no. 517.
Groopman, J.D. and Donahue, K.F. (1988) Aflatoxin, a human carcinogen: determination in foods and biological samples by monoclonal antibody affinity chromatography. Journal of the Association of Official Analytical Chemists, 71(5), 861–867.
Groopman, J.D., Cain, L.G. and Kensler, T.W. (1988) Aflatoxin exposure in human populations: measurements and relationship to cancer. CRC Critical Reviews in Toxicology, 19(2), 113–145.
Gumbmann, M.R. and Williams, S.N. (1969) Biochemical effects of aflatoxin in pigs. Toxicology and Applied Pharmacology, 15, 393–04.
Gurtoo, H.L., Dahms, R.P. and Paigen, B. (1978) Metabolic activation of aflatoxins related to their mutagenicity. Biochemical and Biophysical Research Communications, 81(3), 965–971.
Habish, H.A., Abdulla, M.H. and Broadbent, J.H. (1971) The incidence of aflatoxin in Sudanese groundnuts. Tropical Science, 13(4), 279–287.
Harvey, R.B., Kubena, L.F., Phillips, T.D. et al. (1989) Prevention of Aflatoxicosis by addition of hydrated sodium calcium aluminosilicate to the diets of growing barrows. American Journal Veterinary Research, 50(3), 416–420.
Hendrickse, R.G., Coulter, J.B.S., Lamplugh, S.M. et al. (1982) Aflatoxins and kwashiorkor: a study in Sudanese children. British Medical Journal, 285, 843–846.
Hendrickse, R.G. (1988) Kwashiorkor and aflatoxins. Journal of Paediatric Gastroenterology and Nutrition, 7, 633–636.
Hill, R.A., Blankenship, P.D., Cole, R.J. and Sanders, T.H. (1983) Effects of soil moisture and temperature on preharvest invasion of peanuts by the Aspergillus flavus group and subsequent aflatoxin development. Applied and Environmental Microbiology, 45(2), 628–633.
Hintz, H.F., Booth, A.N., Cucullu, A.F. et al. (1967) Aflatoxin toxicity in swine. Journal of PSEBM, 124, 266–268.
Hodges, R., Mortimer, P.H. and Drew Smith, J. (1964) Toxic Groundnuts offered for human consumption in New Zealand. The New Zealand Veterinary Journal, 12, 19–20.
Holaday, C.E. (1968) Rapid method for detecting aflatoxins in peanuts. Journal of the American Oil Chemists’ Society, 45, 680–688.
Holaday, C.E. and Lansden, J. (1975) Rapid screening method for aflatoxin in a number of products. Journal of Agriculture and Food Chemistry, 23(6), 1134–1136.
Horrocks, D., Burt, A.W.A., Thomas, D.C. and Lancaster, M.C. (1965) Effects of groundnut meal containing aflatoxin in cattle diets. Animal Production, 7, 253–261.
Hsieh, L.-L., Hsu, S.-W., Chen, D.-S. and Santella, R.M. (1988) Immunological detection of aflatoxin B1-DNA adducts formed in vivo. Cancer Research, 48, 6328–6331.
Hurst, W.J. and Toomey, P.B. (1978) Determination of aflatoxins in peanut products using reverse phase HPLC. Journal of Chromatographic Science, 16(8), 372–376.
Jarvis, B. (1971) Factors affecting the production of mycotoxins. Journal of Applied Bacteriology, 34(1), 199–213.
Joffe, A.Z. (1969) Relationships between Aspergillus flavus, A. niger and some other fungi in the mycoflora of groundnut kernels. Plant and Soil XXXI, 1, 57–63.
Kannaiyan, J., Sandhu, R.S. and Phiri, A.L. (1989) Aflatoxin and Aspergillus flavus contamination problems of groundnuts in Zambia, in Aflatoxin contamination of groundnut: Proceedings of the International Workshop, 6–9 Oct. 1987, ICRISAT, Patancheru, pp. 65–70.
Keen, P. and Martin, P. (1971) The toxicity and fungal infestation of foodstuffs in Swaziland in relation to harvesting and storage. Tropical and Geographical Medicine, 23(1), 35–43.
Knutti, R. and Schlatter, C. (1982) Distribution of aflatoxin in whole peanut kernels, sampling plans for small samples. Zeitschrift fur Lebensmittelchemie Unters Forsch, 174, 122–128.
Korobkin, M. and Williams, E.H. (1968) Hepatoma and groundnuts in the West Nile district of Uganda. Yale Journal of Biology and Medicine, 41, 69–78.
Krishnamachari, K.A., Bhat, R.V., Nagaragan, V. and Tilak, T.B. (1975) Hepatitis due to aflatoxicosis — an outbreak in West India. Lancet, 1, 1061–1063.
Kubena, L.F., Harvey, R.B., Phillips, T.D. et al. (1990) Diminution of Aflatoxicosis in growing Chickens by the dietary addition of a hydrated, sodium calcium aluminosilicate. Poultry Science, 69, 727–735.
Lamplugh, S.M., Hendrickse, R.G., Apaegyei, F. and Mwanmut, D.D. (1988) Aflatoxins in breast milk, neonatal cord blood, and serum of pregnant women. British Medical Journal, 296, 968.
Lancaster, M.C, Jenkins, F.P. and Philp, J.McL. (1961) Toxicity associated with certain samples of groundnuts. Nature, 192, 1095–1096
Lazaro, F., de Castro, M.D.L. and Valcarcel, M. (1988) Fluorimetric determination of aflatoxins in foodstuffs by high-performance liquid chromatography with flow injection analysis. Journal of Chromatography, 448, 173–181.
Lee, L.S., Cucullu, A.F., Franz, A.O. Jr. and Pons, W.A. Jr. (1969) Destruction of aflatoxins in peanuts during dry and oil roasting. Journal of Agriculture and Food Chemistry, 17(3), 451–453.
Lee, L.S. and Cucullu, A.F. (1978) Conversion of aflatoxin B1 to aflatoxin D1 in ammoniated peanut and cottonseed meals. Journal of Agriculture and Food Chemistry, 26(4), 881–884.
Lee, H.-S, Sarosi, I. and Vyas, G.N. (1989) Aflatoxin B1 formamidopyrimidine adducts in human hepatocarcinogenesis: A preliminary report. Gastroenterology, 97, 1281–1287.
Lim, Han Kuo and Yeap, Gim Sai. (1966) The occurrence of aflatoxin in Malayan imported oil cakes and groundnut kernels. The Malaysian Agricultural Journal, 45(3), 232–244.
Lipsky, M.M., Cole, K.E., Hsu, I.-C. et al. (1990) Interspecies comparisons of in vitro hepatocarcinogenesis. Progress in Clinical and Biological Research, 331, 395–408.
Llewellyn, G.C., Johnson, R.H. and O’Rear, C.E. (1983) A model for evaluating aflatoxin occurrence in shelled peanuts, in Biodeterioration 5, (ed. T.A. Oxley and S. Barry), 5th International Biodeterioration Symposium, Aberdeen, pp. 638–651.
Llewellyn, G.C, O’Rear, CE., Sherertz, P.C. et al. (1988) Aflatoxin contamination of Virginia peanuts for the crop-years 1982–1986. International Biodeterioration, 24(4 & 5), 399–407.
Loosmore, R.M. and Markson, L.M. (1961) Poisoning of cattle by Brazilian groundnut meal. Veterinary Record, 73, 813–814.
Loosmore, R.M. and Harding, J.D.J. (1961) A toxic factor in Brazilian groundnuts causing liver damage in pigs. Veterinary Record, 73, 1362–1364.
Lotlikar, P.D., Raj, H.G., Bohm, L.S. et al. (1989) A mechanism of inhibition of aflatoxin B1-DNA binding in the liver by phenobarbital pretreatment of rats. Cancer Research, 49, 951–957.
Lovelace, CE.A. and Aalbersberg, W.G.L. (1989) Aflatoxin levels in foodstuffs in Fiji and Tonga Islands. Plant Foods for Human Nutrition, 39, 393–399.
Lutwick, L.I. (1979) Relation between aflatoxin, hepatitis-B virus and hepatocellular carcinoma. Lancet, 1, 755–775.
McLean. A.E.M. and Marshall. A. (1971) Reduced carcinogenic effects of aflatoxin in rats given phenobarbitone. British Journal of Experimental Pathology, 52, 322–329.
Manzo, S.K. and Misari, S.M. (1989) Status and management of aflatoxin in groundnuts in Nigeria, in Aflatoxin contamination of groundnut: Proceedings of the International Workshop, 6–9 Oct. 1987, ICRISAT, Patancheru, pp. 77–90.
Mehan, V.K., Bhavanishankar, T.N.I, and Bedi, J. (1985) Comparison of different methods of extraction and estimation of aflatoxin B1 in groundnut. Journal of Food Science and Technology, 22(2), 123–125.
Mortimer, D.N., Shepherd, M.J., Gilbert, J. and Clark, C. (1988) Enzyme-linked immunosorbent (ELISA) determination of aflatoxin B1 in peanut butter, collaborative trial. Food Additives and Contaminants, 5(4), 601–608.
Moss, E. and Neal, G.E. (1985) The metabolism of aflatoxin B1 by human liver. Biochemical Pharmacology, 34(17), 3193–3197.
Murthy, T.R.K., Jammali, M., Henry, Y. and Frayssinet, C. (1975) Aflatoxin residues in tissues of growing swine: effect of separate and mixed feeding of protein and protein-free portions of the diet. Journal of Animal Science, 41(5), 1339–1347.
Nakazato, M., Morozumi, S., Saito, K. et al. (1990) Interconversion of aflatoxin B1 and aflatoxicol by several fungi. Applied and Environmental Microbiology, 56(5), 1465–1470.
Natarajan, K.R., Rhee, K.C., Cater, CM. and Mattil, K.F. (1975a) Distribution of aflatoxins in various fractions separated from raw peanuts and defatted peanut meal. Journal of the American Oil Chemists’ Society, 52(2), 44–47.
Natarajan, K.R., Rhee, K.C, Cater, CM. and Mattil, K.F. (1975b) Destruction of aflatoxins in peanut protein isolates by sodium hypochlorite. Journal of the American Oil Chemists’ Society, 52(5), 160–163.
Newberne, P.M. and Butler, W.H. (1969) Acute and chronic effects of aflatoxin on the liver of domestic and laboratory animals. A review. Cancer Research, 29, 236–250.
Ngindu, A., Johnson, B.K., Kenya, P.R. et al. (1982) Outbreak of acute hepatitis caused by aflatoxin poisoning in Kenya. Lancet, 1, 1346–1348.
O’Brien, K., Moss, E., Judah, D. and Neal, G. (1983) Metabolic basis of the species difference to aflatoxin B1 induced hepatoxicity. Biochemical and Biophysical Research Communications, 114(2), 813–821.
Paget, G.E. (1954) Exudative hepatitis in guinea-pigs. Journal of Pathology and Bacteriology, 67, 393–400.
Park, D.L., Lee, L.S., Price, R.L. and Pohland, A.E. (1988) Review of the Decontamination of Aflatoxins by Ammoniation: Current Status and Regulation. Journal of the Association of Official Analytical Chemists, 71(4), 685–703.
Park, D.L., Miller, B.M., Nesheim, S. et al. (1989) Visual and semiquantitative spectro-photometric ELISA screening method for aflatoxin B1 in corn and peanut products: follow-up collaborative study. Journal of the Association of Official Analytical Chemists, 72(4), 638–643.
Park, D.L., Nesheim, S., Trucksess, M.W. et al. (1990) Liquid Chromatographic Method for Determination of Aflatoxins B1, B2, G1 and G2 in Corn and Peanut Products: Collaborative Study. Journal of the Association of Official Analytical Chemists, 73(2), 260–266.
Parker, W.A. and Melnick, D. (1966) Absence of Aflatoxin from Refined Vegetable Oils. Journal of the American Oil Chemists’ Society, 42, 635–638.
Patel, U.D., Govindarajan, P. and Dave, P.J. (1989) Inactivation of aflatoxin BL by using the synergistic effect of hydrogen peroxide and gamma radiation. Applied and Environmental Microbiology, 55(2), 465–467.
Paterson, J.S., Crook, J.C, Shand, A. et al. (1962) Groundnut toxicity as the cause of exudative hepatitis (oedema disease) of guinea-pigs. Veterinary Record, 74, 639–640.
Patey, A.L., Sharman, M., Wood, R. and Gilbert, J. (1989) Determination of aflatoxin concentrations in peanut butter by enzyme-linked immunosorbent assay (ELISA): Study of three commercial ELISA kits. Journal of the Association of Official Analytical Chemists, 72(6), 965–969.
Patey, A.L., Sharman, M. and Gilbert, J. (1991) Liquid chromatographic determination of aflatoxin levels in peanut butters using an immunoaffinity column cleanup method: International Collaborative trial. Journal of the Association of Official Analytical Chemists, 74(1), 76–81.
Pettit, R.E. (1986) Incidence of aflatoxin in groundnuts as influenced by seasonal changes in environmental conditions — A review, in Agrometeorology of Groundnut, Proceedings of an International Symposium, 21–26 August, 1985, ICRISAT Sahelian Center, Niamey, Niger. ICRISAT, Patancheru, pp. 163–174.
Pettit, R.E., Azaizeh, H.A., Taber, R.A. et al. (1989) Screening groundnut cultivars for resistance to Aspergillus flavus, Aspergillus parasiticus, and aflatoxin contamination, in Aflatoxin contamination of groundnut: Proceedings of the International Workshop, 6–9 Oct. 1987, ICRISAT, Patancheru, pp. 291–303.
Pettit, R.E., Sarr, B.A., Machen, M.D. and Phillips, T.D. (1990) Detection and detoxification of aflatoxin-contaminated groundnut products in West Africa, in Summary Proceedings of the First ICRISAT Regional Groundnut Meeting for West Africa, 13–16 September, 1988, pp. 97–98.
Platonow, N. and Beauregard, M. (1965) Feeding of ferrets with the raw meat and liver of chickens chronically poisoned with toxic groundnut meal. Canadian Journal of Comparative Medicine and Veterinary Science, 29, 63–65.
Pluyer, H.R., Ahmed, E.M. and Wei, C.I. (1987) Destruction of aflatoxins on peanuts by oven and microwave-roasting. Journal of Food Protection, 50(6), 504–508.
Pons, W.A., Jr. and Franz, A.O., Jr. (1978) High pressure liquid chromatographic determination of aflatoxins in peanut products. Journal of the Association of Official Analytical Chemists, 61(4), 793–800.
Portman, R.S., Plowman, K.M. and Campbell, T.C. (1968) Aflatoxin metabolism by liver microsomal preparations of two different species. Biochemical and Biophysical Research Communications, 33(5), 711–715.
Ramsdell, H.S. and Eaton, D.L. (1990) Species susceptibility of aflatoxin B1 carcinogenesis: comparative kinetics of microsomal biotransformation. Cancer Research, 50, 615–620.
Ray, A.C., Abbitt, B., Cotter, S.R. et al. (1986) Bovine abortion and death associated with consumption of aflatoxin-contaminated peanuts. Journal of the American Veterinary Medical Association, 188(10), 1187–1188.
Rayner, E.T. and Dollear, F.G. (1968) Removal of aflatoxins from oilseed meals by extraction with aqueous isopropanol. Journal of American Oil Chemists’ Society, 45, 622–624.
Reed, J.D. and Kasali, O.B. (1989) Hazards to livestock of consuming aflatoxin-contaminated groundnut meal in Africa, in Aflatoxin contamination of groundnut: Proceedings of the International Workshop, 6–9 Oct. 1987, ICRISAT, Patancheru, pp. 31–38.
Robinson, P. (1967) Infantile cirrhosis of the liver in India with special reference to probable aflatoxin etiology. Clinical Paediatrics, 6, 57–62.
Roebuck, B.D. and Wogan, G.N. (1977) Species comparison of in vitro metabolism of aflatoxin B1. Cancer Research, 37, 1649–1656.
Rogan, W.R., Yang, G.C. and Kimbrough, R.D. (1985) Aflatoxin and Reye’s Syndrome: A Study of Livers from Deceased Cases. Archives of Environmental Health, 40(2), 91–95.
Ryan, N.J., Hogan, G.R., Hayes, W. et al. (1979) Aflatoxin B1 Its Role in the Etiology of Reye’s Syndrome. Paediatrics, 64(1), 71–75.
Salhab, A.S. and Edwards, G.S. (1977) Comparative in vitro metabolism of aflatoxicol by liver preparations from animals and humans. Cancer Research, 37, 1016–1021.
Sanders, T.H., Davis, N.D. and Diener, U.L. (1968) Effect of carbon dioxide, temperature and relative humidity on production of aflatoxin in peanuts. Journal of the American Oil Chemists’ Society, 45, 683–685.
Sanders, T.H., McMeans, J.L. and Davidson, J.I. (1984) Aflatoxin content of peanut hulls. Journal of the American Oil Chemists’ Society, 61(12), 1839–1841.
Sanders, T.H., Cole, R.J., Blankenship, P.D. and Hill, R.A. (1985a) Relation of environmental stress duration to Aspergillus flavus invasion and aflatoxin production in preharvest peanuts. Peanut Science, 12, 90–93.
Sanders, T.H., Blankenship, P.D., Cole, R.J. et al. (1985b) Conclusive test for aflatoxin resistance in peanuts. Journal of the American Oil Chemists’ Society, 62(4), 654–655.
Sargeant, K., O’Kelly, J., Carnaghan, R.B.A. and Allcroft, R. (1961a) The assay of a toxic principle in certain groundnut meals. Veterinary Record, 73(46), 1219–1223.
Sargeant, K., Allcroft, R. and Carnaghan, R.B.A. (1961b) Groundnut toxicity. Veterinary Record, 73, 865.
Sargeant, K., Sheridan, A. and O’Kelly, J. (1961c) Toxicity associated with certain samples of groundnuts. Nature, 192, 1096–1097.
Sargeant, K., Carnaghan, R.B.A. and Allcroft, R. (1963) Toxic Products in Groundnuts: Chemistry and Origin. Chemistry and Industry, 12 January, 1963, 53–55.
Sarnaik, S., Godbole, S.H. and Kanekar, P. (1988) Incidence of toxigenic Aspergillus flavus in marketed edible vegetable oils. Current Science, 57(24), 1336–1337.
Schindler, A.F., Palmer, J.G. and Eisenberg, W.V. (1967) Aflatoxin production by Aspergillus flavus as related to various temperatures. Applied Microbiology, 15, 1006–1009.
Schroeder, H.W. and Boller, R.A. (1973) Aflatoxin production of species and strains of the Aspergillus flavus group isolated from field crops. Applied Microbiology, 25(6), 885–889.
Serck-Hanssen, A. (1970) Aflatoxin-induced fatal hepatitis? A case report from Uganda. Archives of Environmental Health, 20, 729–731.
Shantha, T. (1989) Detoxification of groundnut seed and products in India, in Aflatoxin contamination of groundnut: Proceedings of the International Workshop, 6–9 Oct. 1987, ICRISAT, Patancheru, pp. 153–160.
Shayiq, R.M. and Avadhani, N.G. (1989) Purification and characterization of a hepatic mitochondrial cytochrome P450 active in aflatoxin B1 metabolism. Biochemistry, 28, 7546–7554.
Shimada, T. and Guengerich, F.P. (1989) Evidence for cytochrome P-450nf, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver. Proceedings of the National Academy of Science, USA, 86, A62–A65.
Shotwell, O.L. and Holaday, C.E. (1981) Minicolumn detection methods for aflatoxin in raw peanuts: collaborative study. Journal of the Association of Official Analytical Chemists, 64(3), 674–677.
Siller, W.G. and Ostler, D.C. (1961) The histopathology of an entero-hepatic syndrome of turkey poults. The Veterinary Record, 73(7), 134–138.
Sisk, D.B., Carlton, W.W. and Curtin, T.M. (1968) Experimental aflatoxicosis in young swine. American Journal of Veterinary Research, 29, 1591–1602.
Siwela, A.H. and Caley, A.D. (1989) Aflatoxin contamination of stored groundnuts in Zimbabwe, in Aflatoxin contamination of groundnut: Proceedings of the International Workshop, 6–9 Oct. 1987, ICRISAT, Patancheru, pp. 59–64.
Smith, J.W., Hill, C.H. and Hamilton, P.B. (1971) The effect of dietary modifications on aflatoxicosis in the broiler chicken. Poultry Science, 50, 768–774.
Sreenivasamurthy, V., Parpia, H.A.B., Srikanta, S. and Shankar Murti, A. (1967) Detoxification of aflatoxin in peanut meal by hydrogen peroxide. Journal of the Association of Official Analytical Chemists, 50(2), 350–354.
Stanton, D.W. (1977) A survey of some foods for aflatoxins. Food Technology in New Zealand, 12(4), 25.
Stoloff, L. (1989) Aflatoxin is not a probable human carcinogen: the published evidence is sufficient. Regulatory Toxicology and Pharmacology, 10, 272–283.
Strange, R.N. (1984) The possible role of phytoalexins in the resistance of groundnuts to Puccinia arachidis Speg. Groundnut Rust Disease, in Groundnut Rust Disease: Proceedings of a Discussion Group Meeting 24–28 September, 1984, ICRISAT, Patancheru, pp. 167–174.
Strzelecki, E.L. and Cader-Strzelecka, B. (1988) A survey of aflatoxin levels in peanut meal imported into Poland for animal feedingstuffs. Food Additives and Contaminants, 5(4), 597–599.
Strzelecki, E.L., Gasiorowska, U., Gorazdowska, M. and Cader-Strzelecka, B. (1990) Contamination of groundnut meal by aflatoxin metabolites of Aspergillus flavus. Microbios Letters, 43, 7–10.
Subrahmanyam, P., Mehan, V.K., Nevill, D.J. and McDonald, D. (1980) Research on Fungal Diseases of Groundnut at ICRISAT, in Proceedings of the International Workshop on Groundnuts, 13–17 October, ICRISAT, Patancheru, pp. 197–198.
Subrahmanyam, P. (1990) Groundnut Diseases in West Africa and their management. Research problems, priorities and future strategies, in Summary Proceedings of the First ICRISAT Regional Groundnut Meeting for West Africa, 13–16 September, 1988, pp. 3–6.
Syamasundara Rao, P. (1970) Study of liver injury in mice fed with spoiled groundnuts. Journal of the Indian Medical Association, 54(1), 6–11.
Sylos, CM. and Rodriguez-Amaya, D.B. (1989) Inexpensive, rapid screening method for aflatoxins in peanuts and peanut products. Journal of the Science of Food Agriculture, 49, 167–172.
Trucksess, M.W., Stack, M.E., Nesheim, S. et al. (1989) Enzyme-linked immunosorbent assay of aflatoxins B1, B2, and G1 in corn, cottonseed, peanuts, peanut butter, and poultry feed: collaborative study. Journal of the Association of Official Analytical Chemists, 72(6), 957–961.
Trucksess, M.W., Young, K., Donahue, K.F. et al. (1990) Comparison of two immunochemical methods with thin-layer chromatographic methods for determination of aflatoxins. Journal of the Association of Official Analytical Chemists, 73(3), 425–429.
Trucksess, M.W., Stack, M.E., Nesheim, S. et al. (1991) Immunoaffinity column coupled with solution fluorometry or liquid chromatography postcolumn derivatization for determination of aflatoxins in corn, peanuts, and peanut butter: Collaborative Study. Journal of the Association of Official Analytical Chemists, 74(1), 81–87.
Tsubouchi, H., Yamamoto, K., Hisada, K. and Sakabe, Y. (1983) Degradation of aflatoxins by Aspergillus niger and aflatoxin non-producing Aspergillus flavus. Journal of the Food Hygienic Society of Japan, 24(2), 113–119.
Tupule, P.G. (1969) Aflatoxicosis. Indian Journal of Medical Research, 57(8), 102–114.
van der Linde, J.A., Frens, A.M., de Iongh, H. and Vies, R.O. (1964) Oonderzoek van melk afkomstig van koejen gevoed met aflatoxinehoudend grondnotenmeel. (Inspection of milk from cows fed aflatoxin-containing groundnut meal). Tijdschrift, Diergeneesk, 89(15), 1082–1088.
Van Dyck, P.J., Tobback, P., Feys, M. and van de Voorde, H. (1982) Sensitivity of aflatoxin B1 to ionizing radiation. Applied and Environmental Microbiology, 43(6), 1317–1319.
Van Egmond, H.P. (1989) Current situation on regulations for mycotoxins. Overview of tolerances and status of standard methods of sampling and analysis. Food Additives and Contaminants, 6(2), 139–188.
Van Egmond, H.P. and Wagstaffe, P.J. (1989) Aflatoxin Bt in peanut meal reference materials: intercomparisons of methods. Food Additives and Contaminants, 6(3), 307–319.
Varsavsky, E. and Sommer, S.E. (1977) Determination of aflatoxins in peanuts. Annals of Nutrition and Metabolism, 31(4/6), 539–544.
Vesonder, R.F., Beckwith, A.C., Ciegler, A. and Dimler, R.J. (1975) Ammonium hydroxide treatment of aflatoxin B1. Some chemical characteristics and biological effects. Journal of Agriculture and Food Chemistry, 23, 242–243.
Viroben, G., Delort-Laval, J., Colin, J. and Adrian, J. (1978) Inactivation des aflatoxines par traitement a l’ammoniac études in vitro de tourteaux d’arachide détoxiqués. Annales de la Nutrition et de l’ Alimentation, 32(1), 167–185.
Waltking, A.E. (1980) Sampling and preparation of samples of peanut butter for aflatoxin analysis. Journal of the Association of Official Analytical Chemists, 63(1), 103–106.
Whitaker, T.B., Dickens, J.W., Monroe, R.J. and Wiser, E.H. (1972) Comparison of the observed distribution of aflatoxin in shelled peanuts to the negative binomial distribution. Journal of the American Oil Chemists’ Society, 49(10), 590–593.
Whitaker, T.B. and Dickens, J.W. (1983) Comparison of the amounts of aflatoxin extracted from raw peanuts using AO AC methods I and II. Peanut Science, 10(2), 52–54.
Whitaker, T.B., Dickens, J.W. and Giesbrecht, F.G. (1984) Effects of methanol concentration and solvent: peanut ratio on extraction of aflatoxin from raw peanuts. Journal of the Association of Official Analytical Chemists, 67(1), 35–36.
Whitaker, T.B., Dickens, J.W. and Chew, V. (1985) Development of statistical models to simulate the testing of farmers stock peanuts for aflatoxin using visual, thin layer chromatography, and minicolumn methods. Peanut Science, 12, 94–98.
Whitaker, T.B. and Dickens, J.W. (1986) Efficacy of the visual minicolumn and thin layer chromatography methods to test farmers stock peanuts for aflatoxin. Peanut Science, 13, 74–77.
Whitaker, T.B., Dickens, J.W. and Giesbrecht, F.G. (1986) Optimum methanol concentration and solvent/peanut ratio for extraction of aflatoxin from raw peanuts by modified AOAC Method II. Journal of the Association of Official Analytical Chemists, 69(3), 508–512.
Whitaker, T.B. and Dickens, J.W. (1989) Simulation of aflatoxin testing plans for shelled peanuts in the United States and in the export market. Journal of the Association of Official Analytical Chemists, 72(4), 644–648.
Wild, CP., Pionneau, F., Montesano, R. et al. (1987). Aflatoxin detected in human breast milk by immunoassay. International Journal of Cancer, 40(3), 328–333.
Wild, CP., Jiang, Y.-Z., Sabbioni, G. etal. (1990) Evaluation of methods for quantitation of aflatoxin-albumin adducts and their application to human exposure assessment. Cancer Research, 50, 245–251.
Wilkinson, A.P., Denning, D.W. and Morgan, M.R.A. (1988) An ELISA method for the rapid and simple determination of aflatoxin in human serum. Food Additives and Contaminants, 5(4), 609–619.
Wilson, D.M., Jay, E. and Hill, R.A. (1985) Microflora changes in peanuts (groundnuts) stored under modified atmospheres. Journal of Stored Product Research, 21(1), 47–52.
Wilson, D.M. (1989) Analytical methods for aflatoxins in corn and peanuts. Archives of Environmental Contamination and Toxicology, 18, 308–314.
Wogan, G.N. and Newberne, P.M. (1967) Dose response characteristics of aflatoxin B1 carcinogenesis in the rat. Cancer Research, 27, 2370–2376.
Wogan, G.N. (1968) Aflatoxin risks and control measures. Federation Proceedings, 27(3), 932–938.
Xiao, D.R. (1989) Research on aflatoxin contamination of groundnut in the People’s Republic of China, in Aflatoxin contamination of groundnut: Proceedings of the International Workshop, 6–9 Oct 1987, ICRISAT, Patancheru, pp. 95–100.
Yabe, K., Ando, Y. and Hamasaki, T. (1988) Biosynthetic relationship among aflatoxins B1, B2, G1 and G2. Applied and Environmental Microbiology, 54, 2101–2106.
Yadgiri, B., Reddy, V., Tulpule, P.G. et al. (1970) Aflatoxin and Indian childhood cirrhosis. American Journal of Clinical Nutrition, 23, 94–98.
Yndestad, M. and Underdal, B. (1975) Aflatoxin in foods on the Norwegian market. Nordic Veterinary Medicine, 27, 42–48.
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Keenan, J.I., Savage, G.P. (1994). Mycotoxins in groundnuts, with special reference to aflatoxin. In: Smartt, J. (eds) The Groundnut Crop. World Crop Series. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0733-4_13
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