Abstract
Amitriptyline is a tricyclic antidepressant with antimuscarinic and sedative properties used particularly for the treatment of endogenous depression. Amitriptyline is demethylated to nortriptyline and then by several other routes to metabolites excreted in urine. Genetic differences result in considerable inter-individual variation in metabolism, plasma half-life varying from 8 to 51 hours. The therapeutic range in plasma for treatment of endogenous depression is 0.1-0.2 μg/ml (combined amitriptyline and nortriptyline concentration).
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© 1995 Springer Science+Business Media New York
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Wilson, J.F. (1995). Amitriptyline. In: Wilson, J.F. (eds) Drugs Eicosanoids. Immunoassay Kit Directory, vol 1 / 3 / 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0679-5_4
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DOI: https://doi.org/10.1007/978-94-011-0679-5_4
Publisher Name: Springer, Dordrecht
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