Abstract
Liposomes are artificial spherical vesicles which contain a small volume of aqueous solution enclosed in a lipid bilayer. Liposomes consist mainly of phospholipids and cholesterol, major components of biological membranes. From the mid-1960s, numerous studies on liposomes have been presented as models of biological membranes to examine physical and chemical characteristics, membrane permeability, membrane leakage, cell-to-cell membrane fusion and cell-membrane interaction. Clinically, from the early 1970s, liposomes have been studied as a drug delivery system (DDS) using techniques of entrapment of ionized or low-molecular weight substances into liposome. Furthermore, integration of antigenic proteins into liposome membranes is being used for vaccination against virus infection. Now, genetic advances are heralding a new application to the use of liposomes, namely liposome-mediated gene delivery.
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Keywords
- Lipid Bilayer
- Cationic Liposome
- Cystic Fibrosis Transmembrane Regulator
- Antisense ODNs
- Human Insulin Gene
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Yanagihara, I., Kaneda, Y., Inui, K., Okada, S. (1995). Liposome-mediated gene transfer. In: Dickson, G. (eds) Molecular and Cell Biology of Human Gene Therapeutics. Molecular and Cell Biology of Human Diseases Series, vol 20. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0547-7_4
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DOI: https://doi.org/10.1007/978-94-011-0547-7_4
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