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Part of the book series: Molecular and Cell Biology of Human Diseases Series ((Mol. Cell Biol. Hu. Dis.,volume 20))

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Abstract

A variety of viral diseases that are refractory to vaccination or therapy are potentially amenable for treatment by gene therapy. Human gene therapy can be defined as the introduction of new genetic material into cells of an individual with resulting therapeutic benefit to the individual (Morgan and Anderson, 1993). Gene therapy for viral diseases requires the introduction of anti-viral genes into cells, to prevent or inhibit viral gene expression or function and consequently limit viral replication and pathogenesis.

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References

  • Azad, R.F., Driver, V.B., Tanaka, K. et al. (1993) Antiviral activity of a phosphoro-thioate oligonucleotide complementary to RNA of the human cytomegalovirus major immediate-early region. Antimicrob. Agents Chemother., 37, 1945.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Bednarik, D.P., Mosca, J.D., Raj, N.B.K., et al. (1989) Inhibition of human immunodeficiency virus (HIV) replication by HIV-trans-activated α2-interferon. Proc. Natl Acad. Sei. USA, 86, 4958.

    Article  CAS  Google Scholar 

  • Bogerd, H. and Greene, W.C. (1993) Dominant negative mutants of human T-cell leukemia virus type I rex and human immunodeficiency virus type 1 Rev fail to multimerize in vivo. J. Virol., 67, 2496.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Bryant, L.A. and Sinclair, J.H. (1993) Inhibition of human cytomegalovirus major immediate early gene expression by antisense RNA expression vectors. J. Virol., 74, 1965.

    Article  CAS  Google Scholar 

  • Buchschacher, G.L. Jr and Panganiban, T. (1992) Human immunodeficiency virus vectors for inducible expression of foreign genes. J. Virol., 66, 2731.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Buonocore, L. and Rose, J.K. (1993) Blockade of human immunodeficiency virus type 1 production in CD4+ T cells by an intracellular CD4 expressed under control of the viral long terminal repeat. Proc. Natl Acad. Sei. USA, 90, 2695.

    Article  CAS  Google Scholar 

  • Caruso, M. and Klatzman, D, (1992) Selective killing of CD4+ cells harboring a human immunodeficiency virus-inducible suicide gene prevents viral spread in an infected cell population. Proc. Natl Acad. Sei. USA, 89, 182.

    Article  CAS  Google Scholar 

  • Chatterjee, S., Johnson, P.R. and Wong, K.K. (1992) Dual-target inhibition of HIV-1 in vitro by means of an adeno-associated virus antisense vector. Science, 258, 1485.

    Article  CAS  PubMed  Google Scholar 

  • Chen, C.J., Banerjea, A.C., Harrison, G.G. et al. (1992) Multitarget-ribozyme directed to cleave at up to nine highly conserved HIV-1 env RNA regions inhibits HIV-1 replication-potential effectiveness against most presently sequenced HIV-1 isolates. Nucleic Acids Res., 20, 4581.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Chuah, M.K.L., VandenDriessche, T. and Morgan, R.A. (1994) Inhibition of human immunodeficiency virus type-1 by retroviral vectors expressing antisense-TAR. Human Gene Ther., 5, 1467.

    Article  CAS  Google Scholar 

  • Cowsert, L.M., Fox, M.C., Zon, G. et al. (1993) In vitro evaluation of phosphoro-thioate oligonucleotides targeted to the E2 mRNA of papillomavirus: potential treatment for genital warts. Antimicrob. Agents Chemother., 37, 171.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Culver, K.W., Ram, Z., Wallbridge, S. et al. (1992) In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science, 256, 1550.

    Article  CAS  PubMed  Google Scholar 

  • Feinberg, M.B. and Trono, D. (1992) Intracellular immunization: trans-dominant mutants of HIV gene products as tools for the study and interruption of viral replication. AIDS Res. Hum. Retroviruses, 8, 1013.

    Article  CAS  PubMed  Google Scholar 

  • Goodarzi, G., Gross, S.C., Tewari, A. et al. (1990) Antisense oligodeoxyribonucleo-tides inhibit the expression of the gene for hepatitis B virus surface antigen. J. Gen. Virol., 71, 3021.

    Article  CAS  PubMed  Google Scholar 

  • Greenberg, P.D. (1992) Phase I study of cellular adoptive immunotherapy using genetically modified CD8+ HIV-specific T cells for HIV seropositive patients undergoing allogeneic bone marrow transplant. Human Gene Ther., 3, 319.

    Article  Google Scholar 

  • Harrisson, G.S., Long, C.J., Curiel, T. et al. (1992) Inhibition of human immunodeficiency virus-1 production resulting from transduction with a retrovirus containing an HIV-regulated diphtheria toxin A chain gene. Human Gene Ther., 3, 461.

    Article  Google Scholar 

  • Heslop, H.E., Brenner, M.K., Rooney, C. et al. (1994) Administration of neomycin resistance gene marked EBV specific cytotoxic T lymphocytes to recipients of mismatched-related or phenotypically similar unrelated donor marrow grafts. Human Gene Ther., 5, 381.

    Article  CAS  Google Scholar 

  • Jolly, D., Chada, S., Townsend, K. et al. (1992) CTL cross reactivity between HIV strains. AIDS Res. Hum. Retroviruses, 8, 1369.

    CAS  PubMed  Google Scholar 

  • Kabanov, A.V., Vinogradov, S.V., Ovcharenko, A.V. et al. (1990) A new class of antivirals: antisense oligonucleotides combined with a hydrophobic substituent effectively inhibit influenza virus reproduction and synthesis of virus-specific proteins in MDCK cells. FEBS Lett., 259, 327.

    Article  CAS  PubMed  Google Scholar 

  • Lee, T.C., Sullenger, B.A., Gallardo, H.F. et al. (1992) Overexpression of RRE-derived sequences inhibits HIV-1 replication in CEM cells. New Biol., 4, 66.

    CAS  PubMed  Google Scholar 

  • Lisziewicz, J., Sun, D., Smythe, J. et al. (1993) Inhibition of human immunodeficiency virus type 1 replication by regulated expression of a polymeric Tat activation response RNA decoy as a strategy for gene therapy in AIDS. Proc. Natl Acad. Set. USA, 90, 8000.

    Article  CAS  Google Scholar 

  • Malim, M.H., Bohnlein, S., Hauber, J. et al. (1989) Functional dissection of the HIV-1 rev trans-activator-derivation of a trans-dominant repressor of rev function. Cell, 58, 205.

    Article  CAS  PubMed  Google Scholar 

  • Malim, M.H., Freimuth, W.W., Liu, J. et al. (1992) Stable expression of trans-dominant rev protein in human T cells inhibits human immunodeficiency virus replication. J. Exp. Med., 176, 1197.

    Article  CAS  PubMed  Google Scholar 

  • Marasco, W.A., Haseltine, W.A. and Chen, S.Y. (1993) Design, intracellular expression, and activity of a human anti-human immunodeficiency virus type 1 gpl20 single-chain antibody. Proc. Natl Acad. Sei. USA, 90, 7889.

    Article  CAS  Google Scholar 

  • Matsuda, Z., Yu, X., Yu, Q.-C. et al. (1993) A virion-speciflc inhibitory molecule with therapeutic potential for human immunodeficiency virus type 1. Proc. Natl Acad. Sei. USA, 90, 3544.

    Article  CAS  Google Scholar 

  • Morgan, R.A. and Anderson, W.F. (1993) Human gene therapy. Annu. Rev. Biochem., 62, 191.

    Article  CAS  PubMed  Google Scholar 

  • Morgan, R.A., Looney, D.J., Muenchau, D.D. et al. (1990) Retroviral vectors expressing soluble CD4: a potential gene therapy for AIDS. AIDS Res. Hum. Retroviruses, 6, 183.

    Article  CAS  PubMed  Google Scholar 

  • Morgan, R.A., Ragheb, J., Chuah, M. et al. (1994) Development of retroviral vectors that optimize the inhibition of HIV-1 at multiple points of the viral life cycle. J. Cell Biochem., (18 Suppl A), 243.

    Google Scholar 

  • Offensperger, W.B., Offensperger, S., Walter, E. et al. (1993) In vivo inhibition of duck hepatitis B virus replication and gene expression by phosphorothioate modified antisense oligodeoxynucleotides. EMBO J., 12, 1257.

    CAS  PubMed  Google Scholar 

  • Pagano, P.S., Jimenez, G., Sung, N.S. et al. (1992) Epstein-Barr viral latency and cell immortalization as targets for antisense oligomers. Ann. N.Y. Acad. Sei., 660, 107.

    Article  CAS  Google Scholar 

  • Pantaleo, G., Graziosi, C, Demarest, J.F. et al. (1993) HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature, 362, 355.

    Article  CAS  PubMed  Google Scholar 

  • Rittner, K. and Sczakiel, J. (1991) Identification and analysis of antisense RNA target regions of the human immunodeficiency virus type 1. Nucleic Acids Res., 19, 1421.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Sarver, N., Cantin, E.M., Chang, P.S. et al. (1990) Ribozymes as potential anti-HIV-1 therapeutic agents. Science, 247, 1222.

    Article  CAS  PubMed  Google Scholar 

  • Schooley, R.T., Merigan, T.C., Gaut, P. et al. (1990) Recombinant soluble CD4 therapy in patients with the acquired immunodeficiency syndrome (AIDS) and AIDS-related complex. Ann. Intern. Med., 112, 247.

    Article  CAS  PubMed  Google Scholar 

  • Shepard, A.A., Tolentino, P. and DeLuca, N.A. (1990) Drafts-Dominant inhibition of herpes simplex virus transcriptional regulatory protein ICP4 by heterodimer formation. J. Virol., 64, 3916.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Steele, C., Cowsert, L.M. and Shillitoe, E.J. (1993) Effects of human papillomavirus type 18-specific antisense oligonucleotides on the transformed phenotype of human carcinoma cell lines. Cancer Res., 53, 2330.

    CAS  PubMed  Google Scholar 

  • Sullenger, A., Gallardo, H.F., Ungers, G.E. et al. (1990) Overexpression of TAR sequences renders cells resistant to human immunodeficiency virus replication. Cell, 63, 601.

    Article  CAS  PubMed  Google Scholar 

  • Sullenger, B.A. and Cech, T.R. (1993) Tethering ribozymes to a retroviral packaging signal for destruction of viral RNA. Science, 262, 1566.

    Article  CAS  PubMed  Google Scholar 

  • Tonkinson, J.L. and Stein, C.A. (1993) Anitsense nucleic acids - prospects for antiviral intervention. Antiviral Chem. Chemother., 4, 193.

    CAS  Google Scholar 

  • Ulmer, J.B., Donnelly, J.J., Parker, S.E. et al. (1993) Heterologous protection against influenza by injection of DNA encoding a viral protein. Science, 259, 1745.

    Article  CAS  PubMed  Google Scholar 

  • von Knebel Doeberitz, M., Rittmuller, C., zur Hausen, H. et al. (1992) Inhibition of tumorigenicity of cervical cancer cells in nude mice by HPV E6-E7 anti-sense RNA. Int. J. Cancer, 51, 831.

    Article  Google Scholar 

  • von Ruden, T. and Gilboa, E. (1989) Inhibition of human T-cell leukemia virus type I replication in primary human T-cells that express antisense RNA. J. Virol., 63, 677.

    Google Scholar 

  • Walker, R. (1993) A study of the safety and survival of the adoptive transfer of genetically marked syngeneic lymphocytes in HIV-infected identical twins. Human Gene Ther., 4, 659.

    Article  CAS  Google Scholar 

  • Warner, J.F., Anderson, C.G., Laube, L. et al. (1991) Induction of HIV-specific CTL and antibody responses in mice using retroviral vector-transduced cells. AIDS Res. Hum. Retroviruses, 7, 645.

    Article  CAS  PubMed  Google Scholar 

  • Weber, P.C., Kenny, J.J. and Wigdahl, B. (1992) Antiviral properties of a dominant negative mutant of the herpes simplex virus type 1 regulatory protein ICPO. J. Gen. Virol., 73, 2955.

    Article  CAS  PubMed  Google Scholar 

  • Weerasinghe, M., Liem, S.E., Asad, S. et al. (1991) Resistance to human immunodeficiency virus type 1 (HIV-1) infection in human CD4+ lymphocyte-derived cell lines conferred by using retroviral vectors expressing an HIV-1 RNA-specific ribozyme. J. Virol., 65, 5531.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Wisotzkey, J.D., Krizenoskas, A., DiAngelo, S. et al. (1993) Cleavage of cottontail rabbit papillomavirus E7 RNA with an anti-E7 ribozyme. Biochem. Biophys. Res. Commun., 192, 833.

    Article  CAS  PubMed  Google Scholar 

  • Wu, G.Y. and Wu, C.H. (1992) Specific inhibition of hepatitis B viral gene expression in vitro by targeted antisense oligonucleotides. J. Biol. Chem., 267, 12436.

    CAS  PubMed  Google Scholar 

  • Yao, G.-Q., Grill, S., Egan, W. et al. (1993) Potent inhibition of Epstein-Barr virus by phosphorothioate oligodeoxynucleotides without sequence specification. Antimicrob. Agents Chemother., 37, 1420.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Yu, M., Ojwang, J., Yamada, O. et al. (1993) A hairpin ribozyme inhibits expression of diverse strains of human immunodeficiency virus type 1. Proc. Natl Acad. Sci. USA, 90, 6340.

    Article  CAS  PubMed  Google Scholar 

  • Zerial, A., Thuong, N.T. and Helene, C. (1987) Selective inhibition of the cytopathic effect of type A influenza viruses by oligodeoxynucleotides covalently linked to an intercalating agent. Nucleic Acids Res., 15, 9909.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

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© 1995 Springer Science+Business Media Dordrecht

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Chuah, M.K.L., Vandendriessche, T., Morgan, R.A. (1995). Anti-viral strategies. In: Dickson, G. (eds) Molecular and Cell Biology of Human Gene Therapeutics. Molecular and Cell Biology of Human Diseases Series, vol 20. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0547-7_10

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  • DOI: https://doi.org/10.1007/978-94-011-0547-7_10

  • Publisher Name: Springer, Dordrecht

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