Abstract
About ten years ago our research group began a systematic study to understand more fully the diverse biological effects of fatty acid unsaturation. After assessing the particular advantages and disadvantages of each method to modify, and thereby define the exact role of membrane lipid unsaturation, we decided to apply the technique of homogeneous catalytic hydrogenation for answering many of specific questions raised in this subject. A vast number of soluble transition metal complexes have also been tested, but though they were able to catalyze the desired reaction, they did not fill the strict requirements for use in biomembrane hydrogenation (biocompatibility, high specific activity under physiological conditions, selectivity, stability, the possibility of removal after completion of reaction).
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References
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Vígh, L., Joó, F. (1995). Catalytic Hydrogenation of Biological Membranes: The Effects on Membrane Physical State and Functions. In: Horváth, I.T., Joó, F. (eds) Aqueous Organometallic Chemistry and Catalysis. NATO ASI Series, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0355-8_27
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DOI: https://doi.org/10.1007/978-94-011-0355-8_27
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