Abstract
Propionyl-L-carnitine (PLC) is a carnitine derivative which has been reported to exert relevant cardiovascular effects. Results from several animal studies seem to indicate that PLC may directly influence the myocardium, thus improving its performance [1, 2]. The aim of this article is to review the cellular electrophysiological effects provoked by PLC.
“It could be hypothesized that action potential duration prolongation, which we have demonstrated to occur in papillary muscles isolated from the heart of rabbits treated for ten days with propionyl-L-carnitine (and which might be due to a reduction in transient outward potassium current), is somehow related to the observed improvement in the contractile properties of the intact myocardium.”
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References
Ferrari R, Ceconi C, Curello S, Pasini E, Visioli O. Protective effect of propionyl-L-carnitine against ischaemia and reperfusion-damage. Mol Cell Biochem 1989; 88: 161–168.
Ferrari R, Di Lisa F, De Jong JW et al. Prolonged propionyl-L-carnitine pre-treatment of rabbit: biochemical, hemodynamic and electrophysiological effects on myocardium. J Mol Cell Cardiol 1992; 24: 219–232.
Aomine M, Arita M. Differential effects of L-propionylcarnitine on the electrical and mechanical properties of guinea pig ventricular muscle in normal and acidic conditions. J Electrocardiol 1987; 20: 287–296.
Aomine M, Arita M, Shimada T. Effects of L-propionylcarnitine on electrical and mechanical alterations induced by amphiphilic lipids in isolated guinea pig ventricular muscle. Heart Vessels 1988; 4: 197–206.
Carbonin PU, Ramacci MT, Pahor M et al. Antiarrhythmic effect of L-propionylcarnitine in isolated cardiac preparations. Cardioscience 1991; 2: 109–114.
Aomine M, Nobe S, Arita M. Electrophysiologic effects of a short-chain acyl carnitine, L-propionylcarnitine, on isolated canine Purkinje fibers. J Cardiovasc Pharmacol 1989; 13: 494–501.
Barbieri M, Carbonin PU, Cerbai E et al. Lack of correlation between the antiarrhythmic effect of L-propionylcarnitine on reoxygenation-induced arrhythmias and its electrophysiological properties. Br J Pharmacol 1991; 102: 73–78.
Paulson DJ, Traxler J, Schmidt M, Noonan J, Shug AL. Protection of the ischaemic myocardium by L-propionylcarnitine: effects on the recovery of cardiac output after ischaemia and reperfusion, carnitine transport, and fatty acid oxidation. Cardiovasc Res 1986; 20: 536–541.
Carbonin PU, Ramacci MT, Pahor M et al. Antiarrhythmic profile of propionyl-L-carnitine in isolated cardiac preparations. Abstr Symp Focus on Propionyl-L-Carnitine, Rome, Italy, 1988.
Kléber AG. Resting membrane potential, extracellular potassium activity, and intracellular sodium activity during acute global ischemia in isolated perfused guinea pig hearts. Circ Res 1983; 52: 442–450.
Amerini S, Carbonin P, Cerbai E, Giotti A, Mugelli A, Pahor M. Electrophysiological mechanisms for the antiarrhythmic action of mexiletine on digitalis-, reperfusion-and reoxygenation-induced arrhythmias. Br J Pharmacol 1985; 86: 805–815.
Ferrier GR, Moffat MP, Lukas A. Possible mechanisms of ventricular arrhythmias elicited by ischemia followed by reperfusion. Studies on isolated canine ventricular tissues. Circ Res 1985; 56: 184–194.
Mugelli A, Amerini S, Piazzesi G, Giotti A. Barium-induced spontaneous activity in sheep cardiac Purkinje fibers. J Mol Cell Cardiol 1983; 13: 697–711.
Amerini S, Bernabei R, Carbonin P, Cerbai E, Mugelli A, Pahor M. Electrophysiological mechanism for the antiarrhythmic action of propafenone: a comparison with mexiletine. Br J Pharmacol 1988; 95: 1039–1046.
Ferrier GR. Digitalis arrhythmias: role of oscillatory afterpotentials. Progr Cardiovasc Dis 1977; 19: 459–474.
Kukushkin NI, Gainullin RZ, Sosunov EA. Transient outward current and rate dependence of action potential duration in rabbit cardiac ventricular muscle. Pflügers Arch 1983; 399: 87–92.
Giles WR, Imaizumi Y. Comparison of potassium currents in rabbit atrial and ventricular cells. J Physiol (Lond) 1988; 405: 123–145.
Boyett MR. Effect of rate-dependent changes in the transient outward current on the action potential in sheep Purkinje fibers. J Physiol (Lond) 1981; 319: 23–41.
Hiraoka M, Kawano S. Mechanism of increased amplitude and duration of the plateau with sudden shortening of diastolic intervals in rabbit ventricular cells. Circ Res 1987; 60: 14–26.
Wohlfart B. Relationships between peak force, action potential duration and stimulus interval in rabbit myocardium. Acta Physiol Scand 1979; 106: 395–409.
Cohen IS, Daytner NB, Gintant GA, Kline RP. Time-dependent outward currents in the heart. In: Fozzard HA, Haber E, Jennings RB, Katz AM, Morgan HE, editors. The heart and cardiovascular system. New York: Raven Press, 1986: 637–671.
Hilgemann DW, Noble D. Excitation-contraction coupling and extracellular calcium transients in rabbit atrium: reconstruction of basic cellular mechanisms. Proc R Soc Lond (Biol) 1987; 230: 163–205.
Wollmer P, Wohlfart B, Khan AR. Effects of 4-aminopyridine on contractile response and action potential of rabbit papillary muscle. Acta Physiol Scand 1981; 113: 183–187.
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© 1995 Springer Science+Business Media Dordrecht
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Mugelli, A., Cerbai, E., Barbieri, M. (1995). Cardiac electrophysiology of propionyl-L-carnitine. In: De Jong, J.W., Ferrari, R. (eds) The Carnitine System. Developments in Cardiovascular Medicine, vol 162. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0275-9_18
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DOI: https://doi.org/10.1007/978-94-011-0275-9_18
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