Skip to main content

Non-Ulcer Dyspepsia

  • Chapter
Ulcer and Non-Ulcer Dyspepsias

Part of the book series: Practical Clinical Medicine ((PCLM))

Abstract

Dyspepsia is a term which covers a multitude of symptoms and has no commonly agreed definition. It is often used interchangeably with indigestion, but has a pseudo scientific ring to it which may be useful in reassuring the patient that his condition is taken seriously, but may unfortunately delude the doctor into believing he has a greater understanding of the patient’s condition than is actually the case. A survey1 conducted recently amongst groups of senior hospital doctors and patients with a variety of gastroenterological and nongastroenterological disorders showed that there was much confusion as to what dyspepsia and indigestion implied. It seems that doctors by and large consider both terms to describe those symptoms typically associated with peptic ulceration. Most patients, on the other hand, though sometimes using the term dyspepsia, are uncertain what it means and are more conversant with indigestion. Unlike their medical counterparts, they are not familiar with the classical symptoms of peptic ulcer and give a less fettered account of what indigestion entails. Many of the symptoms which patients in that survey listed as indigestion, whether they were perennial or only occasional sufferers, more closely resembled irritable bowel syndrome than peptic ulceration. In this study1 we were careful not to bias our findings in favour of the hypothesis that indigestion may equate with a functional bowel disorder by excluding patients with such a diagnosis. The study revealed that 80% of those questioned suffered occasional indigestion. Only half of the patients understood what dyspepsia meant, but most of the doctors considered that indigestion and dyspepsia were synonymous. Not surprisingly, around four-fifths of the patients and doctors included upper abdominal pain, wind, heartburn and acid regurgitation as typical indigestion/dyspepsia symptoms. More surprisingly, over half of the patients listed lower abdominal pain and irregular bowel habit, especially constipation, as characteristic features of indigestion and just less than half also included headache and backache. The majority considered that predominant causes were heavy meals, over spiced food, alcohol and worry. A similar proportion felt that relief was best achieved by taking antacids or laxatives, particularly if the preparation induced belching. Interestingly the patients, unlike the doctors, did not accept that drinking milk was likely to give relief.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Kingham, J. G. C., Fairclough, P. D. and Dawson, A. M. (1983). What is indigestion? J. R. Soc. Med., 76, 183–186

    PubMed  CAS  Google Scholar 

  2. Knill Jones, R. P. (1985). A formal approach to symptoms in dyspepsia. Clin. Gastroenterol., 14, 517–529

    Google Scholar 

  3. Harvey, R. F., Silih, S.Y. and Read, A. E. (1983). Organic and functional disorders in 2000 gastroenterology outpatients. Lancet, 1, 63 2634

    Article  PubMed  CAS  Google Scholar 

  4. Thompson, W. G. and Heaton, K. W. (1980). Functional bowel disorder in apparently healthy people. Gastroenterology, 79, 283–288

    PubMed  CAS  Google Scholar 

  5. Moynihan, B. G. A. (1905). On duodenal ulcer with notes of 52 operations. Lancet, 1, 340–346

    Article  Google Scholar 

  6. Horrocks, J. C. and De Dombal, F. T. (1978). Clinical presentation of patients with dyspepsia. Gut, 19, 19–26

    Article  PubMed  CAS  Google Scholar 

  7. Crean, G. P. (1985). Towards a positive diagnosis of irritable bowel syndrome. In Read, N. W. (ed.) Irritable Bowel Syndrome, pp. 29–42, ( London: Grune and Stratton )

    Google Scholar 

  8. Horrocks, J. C. and De Dombal, F. T. (1975). Diagnosis of dyspepsia from data collected by a physician’s assistant. Br. Med. J., 3, 42 1423

    Google Scholar 

  9. Swarbrick, E. T., Hegarty, J. E., Bat, L., Williams, C. B. and Dawson, A. M. (1980). Site of pain from the irritable bowel. Lancet, 2, 443–446

    Article  PubMed  CAS  Google Scholar 

  10. Thompson, W. G. (1979). The Irritable Gut, p. 18. ( Baltimore: University Park Press )

    Google Scholar 

  11. Kingham, J. G. C. and Dawson, A.M. (1985). Origin of chronic right upper quadrant pain. Gut, 26, 783–788

    Article  PubMed  CAS  Google Scholar 

  12. Dworken, H. J. (1952). Supradiaphragmatic reference of pain from the colon. Gastroenterology, 22, 222–231

    PubMed  CAS  Google Scholar 

  13. Moriarty, K. J. and Dawson, A. M. (1982). Functional abdominal pain–further evidence that whole gut is affected. Br. Med. J., 284, 1670–1672

    Article  CAS  Google Scholar 

  14. Hinkel, C. L. and Moller, G. A. (1957). Correlation of symptoms, age, sex and habits with cholecystographic findings in 1000 consecutive examinations. Gastroenterology, 32, 807–815

    PubMed  CAS  Google Scholar 

  15. Koch, J. P. and Donaldson, R. M. (1964). A survey of food intolerances in hospitalized patients. N. Engl. J. Med., 271, 13, 657–660

    Article  PubMed  CAS  Google Scholar 

  16. Bainton, D. (1976). Gall bladder disease. N. Engl. J. Med., 294, 1147 1149

    Google Scholar 

  17. Price, W. H. (1963). Gall bladder dyspepsia. Br. Med. J., 3, 138–141

    Article  Google Scholar 

  18. Waller, S. L. and Misiewicz, J. J. (1969). Prognosis in the irritable bowel syndrome. Lancet, 2, 753–756

    Article  Google Scholar 

  19. Jones, A. F. (1967). Burbulence. Practitioner, 198, 367–370

    PubMed  CAS  Google Scholar 

  20. Lasser, R. B., Bond, J. H. and Levitt, M. D. (1975). The role of intestinal gas in functional abdominal pain. N. Engl. J. Med., 293, 524–626

    Article  PubMed  CAS  Google Scholar 

  21. Benjamin, S. B., Gerhardt, D. C. and Castell, D. O. (1979). High amplitude, peristaltic oesophageal contractions associated with chest pain and/or dysphagia. Gastroenterology, 77, 478–483

    PubMed  CAS  Google Scholar 

  22. Gomez, Joan and Dally, P. (1977). Psychologically mediated abdominal pain in surgical and medical outpatient clinics. Br. Med. J., 1, 1451–1453

    Article  PubMed  CAS  Google Scholar 

  23. Thompson, W. G. (1984). Non-ulcer dyspepsia. Can. Med. Assoc. J., 1, 330, 565–569

    Google Scholar 

  24. Carr-Locke, D. L. (1984). Biliary dyskinesia, gall bladder dyskinesia and biliary stenosis. In Bouchier, I. A. D., Allan, R. N., Hodgson, H. J. F. and Keighley, M. R. C. (eds.) Textbook of Gastroenterology, pp. 1428–1450 ( London: Balliere Tindall )

    Google Scholar 

  25. Ivy, A. C. (1934). Biliary dyskinesia. Ann. Intern. Med., 8, 115–122

    Google Scholar 

  26. Best, R. R. and Hicken, N. F. (1936). Cholangiographic demonstration of biliary dyssynergia. J. Am. Med. Assoc., 107, 1615–1620

    Article  Google Scholar 

  27. Pope, C. E. (1976). Pathophysiology and diagnosis of reflux oesophagitis. Gastroenterology, 70, 445–454

    PubMed  Google Scholar 

  28. Lagarde, S. P. and Spiro, H. M. (1984). Non-ulcer dyspepsia. Clin. Gastroenterol., 13, 437–446

    PubMed  CAS  Google Scholar 

  29. Joffe, S. N. and Sankar, M. Y. (1984). Duodenitis. In Bouchier, I. A. D., Allan, R. N., Hodgson, H. J. F. and Keighley, M. R. B. (eds.) Textbook of Gastroenterology, pp. 125–128 ( London: Balliere Tindall )

    Google Scholar 

  30. Strickland, R. G. (1984). Gastritis. In Bouchier, I. A. D., Allan, R N, Hodgson, H. J. F. and Keighley, M. R. B. (eds.) Textbook of Gastroenterology, pp. 113–124. ( London: Balliere Tindall )

    Google Scholar 

  31. Nyron, O., Adami, H., Bates, S., Bergstrom, R., Gustaysson, S., Loof, L. and Nyberg, A. (1986). Absence of therapeutic benefit from antacids or Cimetidine in non-ulcer dyspepsia. N. Engl. J. Med., 314, 339–343

    Article  Google Scholar 

  32. Johnson, A. G. (1975). Cholecystectomy and gall stone dyspepsia. Ann R . Coll. Surg. Engl., 56, 69–80

    PubMed  CAS  Google Scholar 

  33. Stanghellini, V. and Malagelada, J. (1983). Gastric manometric abnormalities in patients with dyspeptic symptoms after fundoplication. Gut, 24, 790–797

    Article  PubMed  CAS  Google Scholar 

  34. You, C. H., Lee, K. Y., Chey, W.Y. and Menguy, R. (1980). Electrographic study of patients with unexplained nausea, bloating and vomiting. Gastroenterology, 79, 311–314

    PubMed  CAS  Google Scholar 

  35. Hill, O. W. and Blendis, L. (1967). Physical and psychological evaluation of non-organic abdominal pain. Gut, 8, 221–229

    Article  PubMed  CAS  Google Scholar 

  36. Talley, N. J. and Piper, D. W. (1986). Major life event stress and dyspepsia of unknown cause: a case controlled study. Gut, 27, 127–134

    Article  PubMed  CAS  Google Scholar 

  37. Whorwell, P. J., McCallum, M., Creed, F. H. and Roberts, C. T. (1986). Non-colonic features of irritable bowel syndrome. Gut, 27, 37–40

    Article  PubMed  CAS  Google Scholar 

  38. Kramlinger, K. G., Swanson, D. W. and Maruta, T. (1983). Are patients with chronic pain depressed? Am. J. Psychiatry, 140, 747–749

    PubMed  CAS  Google Scholar 

  39. Petersen, H. (1981). Further investigations and treatment of non-ulcer dyspepsia. Scand. J. Gastroenterol., 17 (Suppl. 79), 130–134

    Google Scholar 

  40. Tyllstrom, J., Adami, H., Agenas, I., Gustaysson, S., Loof, L., Nyberg, A., Nyren, O. and Wilholm, B. (1984). The clinical diagnosis of gastritis–aspects of current therapy and drug consumption. Scand. J. Gastroenterol., 19, 755–760

    PubMed  CAS  Google Scholar 

  41. Saunders, J. H. B., Oliver, R.J. and Higson, D. L. (1986). Dyspepsia: incidence of non-ulcer disease in a controlled trial of Ranitidine in general practice. Br. Med. J., 292, 665–668

    Article  CAS  Google Scholar 

  42. Giorgi-Conciato, M., Daniotti, S. and Ferrarri, P. A. et al (1982). Efficacy and safety of Pirenzepine in peptic ulcer and in non-ulcerous gastroduodenal diseases. A multicentre controlled clinical trial. Scand. J. Gastroenterol., 17 (Suppl. 81), 1–41

    Google Scholar 

  43. Lance, P., Filipe, M. I., Schiller, K. F. R. and Wastell, C. (1981). Cimetidine for non-ulcer dyspepsia. Gastroenterology, 80, 1203

    Google Scholar 

  44. Whorwell, P. J., Prior, A. and Faragher, E. B. (1984). Controlled trial of hypnotherapy in the treatment of severe refractory irritable bowel syndrome. Lancet, 2, 1232–1233

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1987 MTP Press Limited

About this chapter

Cite this chapter

Kingham, J.G.C. (1987). Non-Ulcer Dyspepsia. In: Lancaster-Smith, M. (eds) Ulcer and Non-Ulcer Dyspepsias. Practical Clinical Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9928-8_4

Download citation

  • DOI: https://doi.org/10.1007/978-94-010-9928-8_4

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-0-85200-691-7

  • Online ISBN: 978-94-010-9928-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics