Skip to main content

Adrenergic control of uterine function

  • Chapter
Spontaneous Abortion

Part of the book series: Advances in Reproductive Health Care ((ARHE,volume 2))

Abstract

A great amount of evidence, obtained from both in vivo and in vitro studies, has accumulated over the years on the importance of the endogenous catecholamines in the modulation of uterine activity. Such evidence is conflicting in several points and, most important, shows that much more information must be provided before we attain a clear picture of this modulation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Andersson, K. E. (1982). Pharmacological inhibition of uterine activity. Acta Obstet. Gynaecol. Scand. Suppl., 108, 17

    Article  CAS  Google Scholar 

  • Andersson, K. E., Ingemarsson, I. and Persson, C. G. A. (1973). Relaxing effects of beta-receptor stimulators in isolated gravid human myometrium. Life Sci., 13, 335

    Article  PubMed  CAS  Google Scholar 

  • Andersson, K. E., Bengtsson, L., Gustafson, I. and Ingemarsson, I. (1975). The relaxing effect of terbutaline on the human uterus during labor. Am. J. Obstet. Gynecol., 121, 602

    CAS  Google Scholar 

  • Arkelund, M. and Andersson, K. E. (1976). Effects of terbutaline on human myometrial activity and endometrial blood flow. Obstet. Gynecol., 83, 673

    Google Scholar 

  • Aucélio, J. G., Calixto, J. B. and Jurkiewicz, A. (1981). Influence of treatment with estradiol and progesterone on the contractile effects of agonists on dog uteri, after calcium removal. Braz. J. Med. Biol. Res., 14, 462 P

    Google Scholar 

  • Batra, S. and Bengtsson, B. ( 1974 Effects of diethyestilboestrol and ovarian steroids on the contractile responses and calcium movements in rat uterine smooth muscle. J. Physiol., 276, 329

    Google Scholar 

  • Batra, S. C. and Daniel, E. E. (1971). Effect of multivalent cations and drugs on Ca uptake by the rat myometrial microsomes. Comp. Biochem. Physiol., 38A, 285

    Article  CAS  Google Scholar 

  • Bengtsson, B. (1982). Factors of importance for regulation of uterine contractile activity. Acta Obstet. Gynaecol. Scand. Suppl., 180, 13

    Article  Google Scholar 

  • Berg, G., Andersson, R. G. G. and Rydén, G. (1982). Effects of selective beta-adrenergic agonists on spontaneous contractions, cAMP levels and phosphodiesterase activity in myometrial strips from pregnant women treated with terbutaline. Gynecol. Obstet. Invest., 14, 56

    Article  PubMed  CAS  Google Scholar 

  • Berg-Johnsen, P. and Nesheim, B. I. (1976). Action of isoprenaline, isoxsuprine and ritodrine in the human non-pregnant myometrium. Acta Pharmacol. Toxicol., 39, 209

    Article  CAS  Google Scholar 

  • Botari, S. P., Vanquelin, G., Kaivez, E., Lescrainier, J. P. and Vokaer, A. (1982). Hormonal regulation of adrenergic receptor subtypes in human myometrium. In Proceedings of Vlth International Symposium of Uterine contractility, Brussels

    Google Scholar 

  • Calixto, J. B., Aucélio, J. G. and Jurkiewicz, A. (1979). Relationship between modulation by estradiol, progesterone and calcium upon the pharmacological reactivity of uteri of dogs. Res. Comm. Chem. Pathol. Pharmacol., 25, 447

    CAS  Google Scholar 

  • Calixto, J. B., Aucélio, J. G. and Valle, J. R. (1982). Effects of neonatal androgenization upon the pharmacological reactivity of dog uteri. Arch. Int. Pharmacodyn. Ther., 260, 63

    PubMed  CAS  Google Scholar 

  • Calixto, J. B. and Simas, C. M. (1982). Effect of isuprenaline, isoxsuprine, terbutaline and orciprenaline on human uteri in vitro. Proceedings of International Symposium of Reproductive Health Care. Changing Concepts in Fertility Regulation, Maui, Hawaii

    Google Scholar 

  • Calixto, J. B. and Aucélio, J. G. (1983). Effect of isoprenaline adrenaline and 5-hydroxytryptamine on potassium and barium chloride-induced contraction of isolated dog uteri. Proceedings of the VIth International Symposium of Uterine Contractility,Brussels (In press)

    Google Scholar 

  • Caritis, S. N., Edelstone, D. and Mueller-Henbach, E. (1979). Pharmacologic inhibition of preterm labor. Am. J. obstet. Gynecol., 133, 557

    PubMed  CAS  Google Scholar 

  • Chernaeva, L. and Milenov, K. (1982). Sensitivity of circular and longitudinal uterine muscles to noradrenaline. Meth. Find. Exp. Clin. Pharmacol., 4, 89

    CAS  Google Scholar 

  • Chow, E. H. M. and Marshall, J. M. (1981). Effects of catecholamines on circular and longitudinal uterine muscle of the rat. Eur. J. Pharmacol., 76, 157

    Article  PubMed  CAS  Google Scholar 

  • Dads, J. (1974). Uterine contractility patterns of the outer and inner zones of the myometrium. Obstet. Gynecol., 44, 315

    Google Scholar 

  • Diamond, J. and Holmes, T. G. (1975). Effects of potassium chloride and smooth muscle relaxants on tension and cyclic nucleotide levels in rat myometrium. Can. J. Physiol. Pharmacol., 53, 1099

    Article  PubMed  CAS  Google Scholar 

  • Fuchs, A. R. (1978). Hormonal control of myometrial function during pregnancy and parturition. Acta Endocrinol. Suppl., 221, 3

    Google Scholar 

  • Hayashida, D. N., Leung, R., Goldfien, A. and Robert, J. M. (1982). Human myometrial adrenergic receptor: identification of the beta-adrenergic receptor by (3H) dihydroalprenolol binding. Am. J. Obstet. Gynecol., 142, 389

    PubMed  CAS  Google Scholar 

  • Hoffman, B. B., Lavin, T. N. and Lefkowitiz, R. J. (1981). Alpha adrenergic receptor subtypes in rabbit uterus: mediation of myometrial contraction arid regulation by estrogens. J. Pharmacol. Exp. Ther., 219, 290

    PubMed  CAS  Google Scholar 

  • Ingemarsson, I. (1976). Effect of terbutaline on premature labor: a double blind placebo-controlled study. Am. J. Obstet. Gynecol., 125, 520

    PubMed  CAS  Google Scholar 

  • Ingemarsson, I. (1979). Terbutaline in obstetrics. Acta Pharmacol. Toxicol. Suppl., 44, 84

    Article  Google Scholar 

  • Ingemarsson, I. (1982). Use of beta-receptor agonists in obstetrics. Acta Obstet. Gynecol. Scand. Suppl., 180, 29

    Article  Google Scholar 

  • Johansson, R. M., Andersson, R. G. G. and Wikberg, J. E. S. (1980). Comparison of beta,- and beta2-receptor stimulation in oestrogen or progesterone dominated rat uterus. Acta Pharmacol. Toxicol., 47, 252

    CAS  Google Scholar 

  • Kano, T. (1982). Effects of estrogen and progesterone on adrenoceptors and cyclic nucleotides in rat uterus. Jpn. J. Pharmacol., 32, 535

    Article  PubMed  CAS  Google Scholar 

  • Kawarabayashi, T. and Marshall, J. M. (1981). Factors influencing circular muscle activity in the pregnant rat uterus. Biol. Reprod., 24, 373

    Article  PubMed  CAS  Google Scholar 

  • Kenakin, T. P. (1982). Theoretical and practical problems with the assessment of intrinsic efficacy of agonists: efficacy of reputed beta,-selective adrenoceptor agonists of beta2-adrenoceptors. J. Pharmacol. Exp. Ther., 223, 416

    PubMed  CAS  Google Scholar 

  • Krall, J. F., Barret, J. D. and Korenman, S. G. (1981). Coupling of beta-adrenoceptors in rat uterine smooth muscle. Biol. Reprod., 24, 859

    Article  PubMed  CAS  Google Scholar 

  • Korenman, S. G. and Krall, J. F. (1977). The role of cyclic AMP in the regulation of smooth muscle cell contraction in the uterus. Biol. Reprod., 16, 1

    Article  PubMed  CAS  Google Scholar 

  • Kuryama, H. and Suzuki, H. (1976). Changes in electrical properties of rat myometrium during gestation and following hormone treatment. J. Physiol., 260, 315

    Google Scholar 

  • Larsen, J. J. (1979). Beta-adrenoceptors in the pregnant and non-pregnant myometrium of the goat and cow. Acta Pharmacol. Toxicol., 44, 132

    Article  CAS  Google Scholar 

  • Lossius, K. and Nesheim, B. I. (1976). Response of isoprenaline in the human pregnant and nonpregnant myometrium. Acta Pharmacol. Toxicol., 39, 198

    Article  CAS  Google Scholar 

  • Marshall, J. M. (1973). Effects of catecholamines on the smooth muscle of the female reproductive tract. Annu. Rev. Pharmacol., 13, 19

    Article  PubMed  CAS  Google Scholar 

  • Marshall, J. M. and Kroeger, E. A. (1973). Adrenergic influences on uterine smooth muscle. Philos. Trans. R. Soc. London., 265, 135

    Article  CAS  Google Scholar 

  • Miller, J. W. (1967). Adrenergic receptors in myometrium. Ann. NY Acad. Sci., 139, 788

    Article  PubMed  CAS  Google Scholar 

  • Moura, R. S. (1981). Effect of terbutaline on the human fetal placental circulation. Br. J. Obstet. Gynaecol., 88, 730

    Article  Google Scholar 

  • Nasmyth, P. A. (1967). The effects of adrenergic agents on smooth muscle other than those of the vascular system. In Root, W. S. and Hofman, F. G. (eds.) Physiological Pharmacology. Vol. IV, pp. 129–177. ( New York: Academic Press )

    Google Scholar 

  • O’Donell, S. R. (1970). A selective beta-adrenoceptor stimulant (Th 1165a) related to orciprenaline. Eur. J. Pharmacol., 12, 35

    Article  Google Scholar 

  • O’Donell, S. R. and Wanstall, J. C. (1974). Potency and selectivity in vitro of compounds related to isoprenaline and orciprenaline on beta-adrenoceptors in the guinea-pig. Br. J. Pharmacol., 52, 407

    Google Scholar 

  • Patersson, J. W., Lulich, K. M. and Goldie, R. G. (1983). A comment on beta,-agonists and their use in asthma. Trends Pharmacol. Sci., 4, 67

    Article  Google Scholar 

  • Persson, C. G. A. (1982). Some beta-adrenoceptor functions of therapeutic interest. Acta. Obstet. Gynecol. Scand. Suppl., 108, 7

    Article  PubMed  CAS  Google Scholar 

  • Pinto, R. M., Lerner, V., Pontelli, H. and Rabow, W. (1967). Effect of estradiol-17ß on oxytocininduced contraction of three separate layers of human pregnant myometrium. Am. J. Obst. Gynecol., 1, 881

    Google Scholar 

  • Polacek, I., Bolan, J. and Daniel, E. E. (1971). Accumulation of adenosine 3’,5’-monophosphate and relaxation in the rat uterus in vitro. Can. J. Physiol. Pharmacol., 49, 999

    Article  PubMed  CAS  Google Scholar 

  • Rinard, G. A. and Chew, C. S. (1975). Interacting effects of estrogen progesterone and catecholamines on rat uterine cyclic AMP and glycogen phosphorilase. Life Sci., 16, 1507

    Article  PubMed  CAS  Google Scholar 

  • Rinard, G. A. and Chew, C. (1978). Uterine cyclic AMP formation: biphasic effect of estrogen on catecholamine sensitivity. Life Sci., 22, 2043

    Article  PubMed  CAS  Google Scholar 

  • Roberts, J. M., Insel, P. A. and Goldifien, R. D. (1977). Alpha-adrenoceptors but not betaadrenoceptors increase in rabbit uterus with oestrogen. Nature (Loud.), 270, 624

    Article  CAS  Google Scholar 

  • Roberts, J. M., Insel, P. A. and Goldifien, A. (1982). Regulation of myometrial adrenoceptors and adrenergic response by sex steroids. Mol. Pharmacol., 20, 52

    Google Scholar 

  • Rubânyi, G. and Csapo, A. I. (1976). The ‘activator-Ca’ of the pregnant and post-partum rabbit uterus. Life Sci., 19, 1239

    Article  PubMed  Google Scholar 

  • Rydén, G., Andersson, R. G. G. and Berg, G. (1982). Is the relaxing effect of beta-adrenergic agonists on the human myometrium only transitory? Acta Obstet. Gynaecol. Scand. Suppl., 108, 47

    Article  Google Scholar 

  • Sullivan, S. F. and Marshall, J. M. (1970). Quantitative evaluation of effects of exogenous amines on contractility of human myometrium in vitro. Am. J. Obstet. Gynecol., 107, 139

    PubMed  CAS  Google Scholar 

  • Williams, L. T. and Lefkowitz, R. J. (1977). Regulation of rabbit myometrial alpha adrenergic receptors by estrogen and progesterone. J. Clin. Invest., 60, 815

    Article  PubMed  CAS  Google Scholar 

  • Woodward, D. L., Bose, D. and Innes, I. R. (1970). The effects of calcium on the contraction of the splenic capsular smooth muscle. Fed. Proc., 29, 669

    Google Scholar 

  • Zuspan, F. P., O’Shaughnessy, R. W., Insel, J. J. and Zuspan, M. (1981). Adrenergic innervation of uterine vasculature in human term pregnancy. Am. J. Obstet. Gynecol., 13, 678

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1984 MTP Press Limited

About this chapter

Cite this chapter

Calixto, J.B., De Medeiros, Y.S., Rae, G.A. (1984). Adrenergic control of uterine function. In: Hafez, E.S.E. (eds) Spontaneous Abortion. Advances in Reproductive Health Care, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9789-5_4

Download citation

  • DOI: https://doi.org/10.1007/978-94-010-9789-5_4

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-9791-8

  • Online ISBN: 978-94-010-9789-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics