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Actions of novel immunoregulants useful in the treatment of arthritis as may be relevant to their toxicity

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Side-Effects of Anti-Inflammatory Drugs

Part of the book series: Inflammation and Drug Therapy Series ((IDTH,volume 2))

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Abstract

The term “immunoregulant” (also referred to as “immunomodulator”) is an appropriate description for most drugs that effect the immune system since they usually possess condition-dependent immunostimulant and immunosuppressant activities1,2. Chemical classification of immunoregulants is extremely difficult in view of the plethora of agents with immunoregulating activity1–3. Functional classification is also a difficult task since immunoregulants act at different locations on the immune system and the exact target cell(s) for many agents has proven elusive4. In this chapter we will review immunoregulatory/immunomodulatory agents Which may have therapeutic usefulness in the treatment of rheumatoid arthritis (RA)5. We intend to concentrate on novel immunoregulatory agents (Table 1) that are currently under evaluation as potential antirheumatic drugs, and in particular discuss potential toxicity problems which may be encountered with such compounds.

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Authors and Affiliations

  1. Department of Experimental Therapeutics, Wyeth Laboratories Inc., PO Box 8299, Philadelphia, PA, 19101, USA

    A. J. Lewis & S. C. Gilman

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  1. A. J. Lewis
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  2. S. C. Gilman
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Editors and Affiliations

  1. Department of Pharmacology, University of Cambridge, and Strangeways Research Laboratory, Hills Road, CB2 2QD, Cambridge, UK

    K. D. Rainsford

  2. Institute of Pharmacology, University of Verona, Verona, Italy

    G. P. Velo

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Lewis, A.J., Gilman, S.C. (1987). Actions of novel immunoregulants useful in the treatment of arthritis as may be relevant to their toxicity. In: Rainsford, K.D., Velo, G.P. (eds) Side-Effects of Anti-Inflammatory Drugs. Inflammation and Drug Therapy Series, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9775-8_27

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  • DOI: https://doi.org/10.1007/978-94-010-9775-8_27

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