Skip to main content
SpringerLink
Log in

Gastrointestinal side-effects of prostaglandins

  • Chapter
Side-Effects of Anti-Inflammatory Drugs

Part of the book series: Inflammation and Drug Therapy Series ((IDTH,volume 2))

Abstract

The beneficial effects of prostaglandins in peptic ulcer disease were appreciated more than a millennium ago by Chinese physicians who used the semen of young adults to treat patients with dyspepsia. The mode of administration, the patient acceptability and side-effects are not recorded. It is now known that semen contains 13 naturally occurring prostaglandinsl. More recently, many derivatives of prostaglandins have been, and are being, studied for use in the treatment of alimentary diseases such as peptic ulceration and oesophagitis, because it has been shown that prostaglandins of the A, E and I types inhibit gastric secretion2. Perhaps more important, studies are now under way to determine whether prostaglandin derivatives can protect the mucosa of the upper alimentary tract against the ubiquitous damage caused by non-steroidal anti-inflammatory drugs (NSAIDs)3.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Fung, WP, Karim, SMM and Tye, CY (1974). Effect of 15(R)15 methyl-prostaglandin E2 methyl ester on healing of gastric ulcers. Lancet, 2, 1012

    Google Scholar 

  2. Robert, A (1984). Prostaglandins: effects on the gastrointestinal tract. Clin Physiol Biochem, 2, 61–69

    PubMed  CAS  Google Scholar 

  3. Simon, LS and Mills, JA (1980). Non-steroidal anti-inflammatory drugs. N Engl J Med, 302, 1179–1185 and 1237–1243

    Google Scholar 

  4. Bennett, A and Fleshler, B (1970). Prostaglandins and the gastrointestinal tract. Gastroenterology, 59, 790–800

    PubMed  CAS  Google Scholar 

  5. Waller, S (1973). Prostaglandins and the gastrointestinal tract. Gut, 14, 402–417

    Article  PubMed  CAS  Google Scholar 

  6. Occhipinti, M (1978). Prostaglandins and gastrointestinal function. Adv Pediatrics, 25, 205–221

    CAS  Google Scholar 

  7. Sanders, KM (1984). Role of prostaglandins in regulating gastric motility. Am J Physiol, 247, G117 - G126

    PubMed  CAS  Google Scholar 

  8. Hunt, JN, Smith, JL, Jiang, CL and Kessler, L (1983). Effect of synthetic prostaglandin E1 analog on aspirin-induced gastric bleeding and secretion. Dig Dis Sci, 28, 897–902

    Article  PubMed  CAS  Google Scholar 

  9. Gullikson, GW, Pautsch, W, Bianchi, RG, Monroy, M and Bauer, R (1985). Comparative effects of misoprostil (SC-29333) and 16,16-dimethyl PGE2 on intestinal fluid transport and myoelectric spiking activity. Gastroenterology, 88, 1408

    Google Scholar 

  10. Gilbert, DA, Surawicz, CM, Silverstein, FE, Weinberg, CR, Saunders, DR, Feld, AD, Sanford, RL, Bergman, D and Washington, P (1984). Prevention of acute aspirin-induced gastric mucosal injury by 15-R-15 methyl prostaglandin E2: An endoscopic study. Gastroenterology, 86, 339–345

    PubMed  CAS  Google Scholar 

  11. Whittle, BJR and Vane, JR (1983). Prostacyclin, thromboxanes, and pros- taglandins - actions and roles in the gastrointestinal tract. In: Glass, GBJ and Sherlock, P (eds), Progress in Gastroenterology, Vol. IV, chap. 1. ( New York: Grune & Stratton )

    Google Scholar 

  12. Soll, AH (1980). Specific inhibition by prostaglandins E2 and I2 of histamine-stimulated (14C) aminopyrine accumulation and cyclic adenosine monophosphate generation by isolated canine parietal cells. J Clin Invest, 65, 1222–1229

    Article  PubMed  CAS  Google Scholar 

  13. Smeaton, LA, Hirst, BH, Allen, A and Garner, A (1983). Gastric and duodenal HCO-3 transport in vivo: influence of prostaglandins. Am J Physiol, 245, G751 - G759

    PubMed  CAS  Google Scholar 

  14. Garner, A, Flemström, G, Allen, A, Heylings, JR and McQueen, S (1984). Gastric mucosal protective mechanisms: roles of epithelial bicarbonate and mucus secretions. Scand J Gastroenterol, 19, Suppl. 101, 79–86

    CAS  Google Scholar 

  15. Jentjens, T, Smits, HL and Strous, GJ (1984). 16,16-dimethyl prostaglandin E2 stimulates galactose and glucosamine but not serine incorporation in rat gastric mucous cells. Gastroenterology, 87, 409–416

    PubMed  CAS  Google Scholar 

  16. Rachmilewitz, D (1980). Prostaglandins and diarrhoea. Dig Dis Sci, 25, 897–899

    Article  PubMed  CAS  Google Scholar 

  17. Selling, JA, Hogan, DL, Koss, MA and Isenberg, JI (1985). Prostaglandin E1 ( Misoprostol) stimulates human duodenal mucosal bicarbonate secretion. Gastroenterology, 88, 1580

    Google Scholar 

  18. Robert, A, Hanchar, AJ, Lancaster, C and Nezamis, JE (1979). Prostacyclin inhibits enteropooling and diarrhoea. In: Vane, JR and Bergström, S (eds), Prostacyclin, chap. 13. ( New York: Raven Press )

    Google Scholar 

  19. Rush, BD and Ruwart, MJ (1984). The role of accelerated colonic transit in prostaglandin-induced diarrhoea and its inhibition by prostacyclin. Br J Pharmacol, 83, 157–159

    PubMed  CAS  Google Scholar 

  20. Goldin, E and Rachmilewitz, D (1983). Prostanoids cytoprotection for maintaining remission in ulcerative colitis. Dig Dis Sci, 28, 807–811

    Article  PubMed  CAS  Google Scholar 

  21. Kauffman, GL and Whittle, BJ (1982). Gastric vascular actions of pros- tanoids and the dual effect of arachidonic acid. Am J Physiol, 242, G582 - G587

    PubMed  CAS  Google Scholar 

  22. Whittle, BJR, Kauffman, GL and Moncada, S (1981). Vasoconstriction with thromboxane A2 induces ulceration of the gastric mucosa. Nature, 292, 472–474

    Article  PubMed  CAS  Google Scholar 

  23. Miller, TA (1983). Protective effects of prostaglandins against gastric mucosal damage: current knowledge and proposed mechanisms. Am J Physiol, 245, G601–623

    PubMed  CAS  Google Scholar 

  24. Bolton, JP and Cohen, MM (1979). Permeability effects of E2 prostaglandins on canine gastric mucosa. Can J Physiol Pharmacol, 57, 1082–1087

    Article  PubMed  CAS  Google Scholar 

  25. Gascoigne, AD and Hirst, BH (1981). Prostaglandins alter the relationship between gastric hydrogen ion concentration and flow: evidence for stimulation of non-parietal secretion in the cat. J Physiol, 316, 427–438

    PubMed  CAS  Google Scholar 

  26. Swierczek, JS and Konturek, SJ (1981). Gastric alkaline response to mucosadamaging agents: effect of 16,16-dimethyl prostaglandin E2. Am J Physiol, 241, G509 - G515

    PubMed  CAS  Google Scholar 

  27. Miller, TA, Kraemer, BB, Henagan, JM and Foucar, CE (1983). Topical 16,16-dimethyl-prostaglandin E2. Effects on gastric morphology, hydrogen ion loss, and bicarbonate secretion. Dig Dis Sci, 28, 641–648

    Article  PubMed  CAS  Google Scholar 

  28. Gibinski, K, Rybicka, J, Mikos, E and Nowak, A (1977). Double-blind clinical trial on gastroduodenal ulcer healing with prostaglandin E2 analogues. Gut, 18, 636–639

    Article  PubMed  CAS  Google Scholar 

  29. Konturek, SJ (1982). Gastric cytoprotection. M Sinai J Med, 49, 355–369

    CAS  Google Scholar 

  30. Dembinski, A and Konturek, SJ (1985). Effects of E, F, and I series prostaglandins and analogues on growth of gastroduodenal mucosa and pancreas. Am J Physiol, 248, G170 - G175

    PubMed  CAS  Google Scholar 

  31. Reinhart, WH, Müller, 0 and Halter, F (1983). Influence of long-term 16,16dimethyl prostaglandin E2 treatment on the rat gastrointestinal mucosa. Gastroenterology, 85, 1003–1010

    CAS  Google Scholar 

  32. Karmali, RA, Horrobin, DF, Menezes, J and Patel, P (1979). The relationship between concentrations of prostaglandin Al, E1, E2 and Fla and rates of cell proliferation. Pharmacol Res Commun, 11, 69–75

    Article  PubMed  CAS  Google Scholar 

  33. Halter, F, Meyrat, P, Fritsche, R, Müller, 0, Lentze, MJ and Koelz, HR (1984). Both topical and systemic treatments with 16,16-dimethyl prostaglandin E2 are trophic to rat gastric mucosa. Scand J Gastroenterol, 19, Suppl. 101, 47–53

    CAS  Google Scholar 

  34. Offerhaus, GJA, Tytgat, GNJ, Samson, G and Weinstein, WM (1984). Cell proliferation kinetics of the gastric mucosa after oral 15(R)-15-methyl prostaglandin E2 administration. Gastroenterology, 86, 1199

    Google Scholar 

  35. Thomas, DR, Philpott, GW and Jaffe, BM (1974). The relationship between concentration of prostaglandin E and rates of cell replication. Exp Cell Res, 84, 40–46

    CAS  Google Scholar 

  36. Arber, N, Fich, A, Zajicek, G and Rachmilewitz, D (1985). Effect of misoprostol and cimetidine on human gastric cell turnover. Gastroenterology, 88, 1710

    Google Scholar 

  37. Uribe, A, Johansson, C and Rubio, C (1985). Effects of prostaglandin E2 on cell kinetics of the rat gastrointestinal mucosa. Gastroenterology, 88, 1621

    Google Scholar 

  38. Bockman, RS (1983). Prostaglandins in cancer: a review. Cancer Invest, 1, 485–493

    Article  PubMed  CAS  Google Scholar 

  39. Fürstenberger, G and Marks, F (1980). Early prostaglandin E synthesis is an obligatory event in the induction of cell proliferation in mouse epidermis in vivo by the phorbol ester TPA. Biochem 8iophys Res Commun, 92, 749–756

    Google Scholar 

  40. Fischer, SM (1984). The role of prostaglandins in tumor production. In: Slaga, TJ (ed.), Mechanisms of Tumor Protection, Vol. II: Tumour Protection and Skin Carcinogenesis, chap. 6. ( Boca Raton, Florida: CRC Press )

    Google Scholar 

  41. Lupulescu, A (1978). Enhancement of carcinogenesis by prostaglandins. Nature, 272, 634–636

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Therapeutics, University of Dundee, Dundee, UK

    E. J. S. Boyd & K. G. Wormsley

Authors
  1. E. J. S. Boyd
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. G. Wormsley
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Pharmacology, University of Cambridge, and Strangeways Research Laboratory, Hills Road, CB2 2QD, Cambridge, UK

    K. D. Rainsford

  2. Institute of Pharmacology, University of Verona, Verona, Italy

    G. P. Velo

Rights and permissions

Reprints and permissions

Copyright information

© 1987 MTP Press Limited

About this chapter

Cite this chapter

Boyd, E.J.S., Wormsley, K.G. (1987). Gastrointestinal side-effects of prostaglandins. In: Rainsford, K.D., Velo, G.P. (eds) Side-Effects of Anti-Inflammatory Drugs. Inflammation and Drug Therapy Series, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9775-8_13

Download citation

  • DOI: https://doi.org/10.1007/978-94-010-9775-8_13

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-9777-2

  • Online ISBN: 978-94-010-9775-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation