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Both E Prostaglandins and prolonged indomethacin treatment exert trophic effects on the gastric mucosa

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Side-Effects of Anti-Inflammatory Drugs

Part of the book series: Inflammation and Drug Therapy Series ((IDTH,volume 2))

Abstract

Evidence has accumulated in recent years from animal experiments that drugs inhibiting acid secretion can stimulate the growth of gastric mucosa. This was first shown in our laboratories, when rats were treated with high doses of metiamide, a precursor of cimetidine1–3. It was later confirmed with cimetidine4 and was subsequently also observed with prolonged antacid treatments5. In all these studies a hyperplasia of the parietal cells was observed. The functional correlate was an acid rebound following discontinuation of drug therapy1,3. It is likely that this trophic effect is mediated by gastrin, the established trophic hormone of the gastrointestinal tract6, since in the rat every high dose of a histamine H2-antagonist or antacid leads to a transient gastrin releasel.

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References

  1. Witzel, L, Halter, F, Olah, AJ and Häcki, WH (1977). Effect of prolonged metiamide medication on the fundic mucosa. Gastroenterology, 73, 797

    PubMed  CAS  Google Scholar 

  2. Witzel, L, Heitz, PU, Halter, F, Olah, AJ, Varga, L, Werner, 0 and Häcki, WH (1979). Effects of prolonge administration of metiamide on serum gastrin, gastrin content of the antrum and gastric corpus and G-cell population in the rat. Gastroenterology, 76, 945

    CAS  Google Scholar 

  3. Halter, F, Witzel, L, Häcki, WH, Olah, AJ, Heitz, PU and Varga, L (1977). Gastric secretion, the parietal cell and gastrin response to histamine H2-receptor antagonists in the rat. Excerpta Medica, Amsterdam, 1081

    Google Scholar 

  4. Crean, GP, Daniel, D, Leslie, GB and Bates, C (1978). The effects of prolonged administration of large doses of cimetidine on the gastric mucosa of rats. In: Cimetidine ( Wastell, C and Lance, P eds), The Westminster Hospital Symposium, Churchill Livingstone, Edinburgh, London, New York, p. 191

    Google Scholar 

  5. Mazzacca, G, Casciogne, F, Budillon, G, D’Agostini, L, Ciminio, L Femiano, C (1978). Parietal cell hyperplasia induced by long-term ministration of antacids to rats. Gut, 19, 798

    CAS  Google Scholar 

  6. Johnson, LR (1976). The trophic action of gastrointestinal hormones. Gastroenterology, 70, 278

    PubMed  CAS  Google Scholar 

  7. Blom, H (1984). Effects gastric mucosal morphology. Gastr of longterm treatment with omeprazole on the gastric mucosal morphology. Scand J Gastroenterol, 19 (Suppl 98), 55

    Google Scholar 

  8. Ekman, L, Hanssen, E, Haun, N,Carlsson, E and Lundberg, C (1985). Toxicological studies on omeprazole. Scand J Gaetroenterol. 20 (Suppl. 108), 53

    Google Scholar 

  9. Poynter, D, Pick, CR, Harcourt, RA(1986). Diffuse gastric carcinomain the rat produced by loxitidine: a long antagonist. Gut (In press)

    Google Scholar 

  10. Larsson, H, Carlsson, E, Hakanson, R, Mattsson, Relation of plasma gastrin concentrations and oxyntic mucosal ECL sity during inhibition of gastric acid secretion in the rat. Gut

    Google Scholar 

  11. Larsson, L, Carlsson, E, Mattson, H, Lundell, L, Sundler, F, Sundell, G, Wallmark, B, Watanaabe, T and Hakanson, R (1986). Plasma gastrin and gastric enterochromaffinlike cell activation and proliferation. Gastroenterology, 90, 391

    PubMed  CAS  Google Scholar 

  12. Reinhart, WH, Miller, O and Halter, F (1983). Influence of long-term 16,16dimethyl prostaglandin E2 treatment on the rat gastrointestinal mucosa. Gastroenterology, 85, 1003

    PubMed  CAS  Google Scholar 

  13. Ippoliti, AF, Isenberg, JI, Maxwell, V (1976). The effect of 16,16-dimethyl prostaglandin E2 on meal stimulated gastric acid secretion and serum gastrin in duodenal ulcer patients. Gastroenterology, 70, 488

    PubMed  CAS  Google Scholar 

  14. Halter, F, Meyrat, P, Fritsche, R, Müller, 0, Lentze, MJ and Koelz, HR (1984). Both topical and systemic treatments with 16,16-dm PGE2 are trophic to rat gastric mucosa. Scand J Gastroenterol, (Suppl. 101 ), 19, 47

    CAS  Google Scholar 

  15. Meyrat, P, Baumgartner, A, Kappeler, M and Halter, F (1984). gastroscopy technique in the rat. Dig Dis Sci, 29, 327

    Google Scholar 

  16. Johansson, C, Aly, A, Kollberg, B, Rubio, C, Erikoinen, T and Helander, HF (1983). Trophic actions of oral E2 prostaglandins on the rat gastrointestinal mucosa. Advances in Prostaglandins, Thromboxane and Leukotriene Research, p. 403

    Google Scholar 

  17. Tytgat, GNJ, Offerhaus, GJA, van Minnen, AJ, Everts, V, Hensen-Logmans, SC and Samson, G (1986). Influence of oral 15(R)-15-methyl prostaglandin E2 on human gastric mucosa. Gastroenterology, 90, 1111

    PubMed  CAS  Google Scholar 

  18. Baumgartner, A, Koelz, HR, Robert, A and Halter, F (1986). Hat die trophische Wirkung von Prostaglandinen auf die Magenschleimhaut eine phsyiologische Bedeutung? Schweiz Med Wochenschr (In press)

    Google Scholar 

  19. Weissenborn, U, Griese, H, Leise, W and Sewing, KF (1983). DNA and RNA synthesis in the gastrointestinal mucosa of acetylsalicyclic acid treated rats and effect of 16,16-dimethyl prostaglandin E2. Gastroenterology, 84, 1349

    Google Scholar 

  20. Dembinski, A and Konturek, SJ (1985). Effects of E, F and I series prostaglandins and analogues on growth of gastroduodenal mucosa and pancreas. Am J Physiol, 248, G170

    Google Scholar 

  21. Uribe, A, Rubio, C and Johansson, C (1986). Cell kinetics of rat gastrointestinal mucosa: autoradiographic study following treatment with 15(R)15 methyl prostaglandin E2. Scand J Gastroenterol (In press)

    Google Scholar 

  22. Fich, A, Arber, N, Sestieri, M, Zajicek, G and Rachmilewicz, D (1985). Effect of misoprostol and cimetidine on gastric cell labeling index. Gastroenterology, 89, 57

    PubMed  CAS  Google Scholar 

  23. Baumgartner, A, Koelz, HR and Halter, F (1986). Indomethacin and turnover of gastric mucosal cells in the rat. Am J Physiol, 250, G830

    PubMed  CAS  Google Scholar 

  24. Croft, DN and Wood, PHN (1967). Gastric mucosa and susceptibility to occult gastrointestinal bleeding caused by aspirin. Br Med J, 1, 137

    Article  PubMed  CAS  Google Scholar 

  25. Eastwood, GL and Quimby, GF (1982). Effect of chronic aspirin ingestion on epithelial proliferation in rat fundus, antrum and duodenum. Gastroenterology, 82, 852

    PubMed  CAS  Google Scholar 

  26. Kuwayama, H and Eastwood, GL (1985). Effects of water immersion, restraint, stress and chronic indomethacin ingestion on gastric antral and fundic epithelial proliferation. Gastroenterology, 88, 362

    PubMed  CAS  Google Scholar 

  27. Graham, DY, Smith, LJ and Dobbs, SM (1983). Gastric adaptation occurs with aspirin administration in man. Dig Dis Sci, 28, 1

    Article  PubMed  CAS  Google Scholar 

  28. Pemberton, RE and Strand, LJ (1979). A review of upper gastrointestinal ef- fects of the newer non-steroidal anti-inflammatory agents. Dig Dis Sci, 24, 53

    Article  PubMed  CAS  Google Scholar 

  29. Willems, G and Lehy, T (1975). Autoradiographic and quantitative studies on parietal and peptic cell kinetics in the mouse. Gastroenterology, 69, 416

    PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Gastrointestinal Unit, Inselspital, University of Berne, Berne, Switzerland

    F. Halter, A. Baumgartner, L. Varga & H. R. Koelz

Authors
  1. F. Halter
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  2. A. Baumgartner
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  3. L. Varga
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  4. H. R. Koelz
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, University of Cambridge, and Strangeways Research Laboratory, Hills Road, CB2 2QD, Cambridge, UK

    K. D. Rainsford

  2. Institute of Pharmacology, University of Verona, Verona, Italy

    G. P. Velo

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© 1987 MTP Press Limited

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Halter, F., Baumgartner, A., Varga, L., Koelz, H.R. (1987). Both E Prostaglandins and prolonged indomethacin treatment exert trophic effects on the gastric mucosa. In: Rainsford, K.D., Velo, G.P. (eds) Side-Effects of Anti-Inflammatory Drugs. Inflammation and Drug Therapy Series, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9775-8_12

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  • DOI: https://doi.org/10.1007/978-94-010-9775-8_12

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-9777-2

  • Online ISBN: 978-94-010-9775-8

  • eBook Packages: Springer Book Archive

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