Abstract
Nanotech nology is the focus of major government research initiatives worldwide, for example in the USA — the National Nanotechnology Initiative (www.nano.gov) [1]. It has been recognized that fullerenes and carbon nanotubes are one of the key building blocks for nanoscale materials [2]. Considering the especially rich chemistry of C60 and its 1 nm dimensions (Figure 1A), one expects that applications of these nanoscale materials to medicine should be possible [3a,b].
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References
W. Schultz, Nanotechnology: The Next Big Thing,’ `Chemical and Engineering News’, May 1, 2000.
B. I. Yakobson and R. E. Smalley, `Fullerene Nanotubes: C 000,000 and Beyond’, Am. Sci 85 (1997) 324.
R. A. Frietas Jr, Nanomedicine, Volume 1: Basic Capabilities’, ( Landes Bioscience, 1999 ).
A. W. Jensen, S. R. Wilson and D. I. Schuster, `Biological Applications of Fullerenes: A Review’, Biorg. Med. Chem. 4 (1996) 767.
S. R. Wilson, `Biological Aspects of Fullerenes’, in `Fullerenes: Chemistry, Physics and Technology’, edited by K. M. Kadish and R. S. Ruoff ( John Wiley & Sons, New York, 2000 ) pp. 437–466.
S. R. Wilson and A. Czamick, `Combinatorial Chemistry: Synthesis and Application’, ( John Wiley and Sons, NY, 1997 ).
R. B. Murphy, Q. Lu and S. R. Wilson, `Multi-substituted fullerenes and methods for their preparation and characterization’, US Patent 6,162, 926 (2000).
H. W. Kroto, J. R. Heath, R. F. Curl and R. E. Smalley, `A new form of elemental carbon —Buckminsterfullerene-C60’, Nature 318 (1985) 162–163.
W. Kratschner, L. D. Lab, K. Fostiropoulos and D. R. Huffman, `Solid C60 a new form of carbon’, Nature 347 (1990) 354–358.
R. P. Sijbesma, G. Srdanov, F. Wudl, J. A. Castoro, C. Wilkins, S. H. Friedman, D. L. DeCamp and G. L. Kenyon, `Synthesis of a Fullerene Derivative for the Inhibition of HIV Enzymes’, J. Am. Chem. Soc. 115 (1993) 6510.
S. H. Friedman, D. L. DeCamp, R. P. Sijbesma, G. Srdanov, E Wud1 and G. L. Kenyon, `Inhibition of the HIV-1 protease by fullerene derivatives: model building studies and experimental verification’, ibid. 115 (1993) 6506.
R. F. Schinazi, R. Sijbesma, G. Srdanov, C. L. Hill and F. Wudl, `Synthesis and virucidal activity of a water-soluble, configurationally stable, derivatized C60 fullerene’, Antimicrobial Agents and Chemotherapy 37 (1993) 1707–1710.
P. Rajagopalan, F. Wudl, R. Y. Schinazi and F. D. Boudinot, `Pharmacokinetics of a Water-Soluble Fullerene in Rats’, ibid. 40 (1996) 2262–2265.
H. Mi, M. E. Tuckerman, D. I. Schuster and S. R. Wilson, `A Molecular Dynamics Study of HIV-1 Protease Complexes with Cbo and Fullerene-Based Anti-Viral Agents’, Proc. Electrochem. Soc. 99–12 (1999) 256–269.
D. I. Schuster, S. R. Wilson and R. F. Schinazi, `Anti-Human Immunodeficiency Virus Activity and Cytotoxicity of Derivatized C60 Buckminsterfullerenes’, Bioorg. Med. Chem. Lett. 6 (1996) 1253–1256.
M. Brettreich and A. Hirsch, `A highly water-soluble dendro[60]fullerene’, Tetrahedron Lett. 27 (1998) 2731.
D. I. Schuster, S. R Wilson, A. N. Kirschner, R. F. Schinazi, S. Schlueter-Wirtz, T. Barnett, S. Martin, J. Ermolieff, J. Tang, M. Brettreich and A. Hirsch, `Evaluation of the Anti-HIV Potency of a Water-Soluble Dendrimeric Fullerene Derivative’, Electrochem. Soc. Proc. 2000–11 (2000) 250.
Principle US suppliers of fullerene-Cbo: BuckyUSA (Houston, Texas, USA, www.flashnet.net/buckyusa) and MER Corporation (Tucson, Arizona, USA, www.mercorp.com).
N. Gharbi, M. Pressac, V. Tomberli, T. Da Ros, M. Brettreich, M. Hadchouel, B Arbeille, F. Trivin, R. Céolin, A. Hirsch, M. Prato, H. Szwarc, R. V. Bensasson and F. Moussa, `In vivo behavior of two C60 derivatives’, Proc. Electrochem. Soc. 2000–11 (2000) 240–243.
L. L. Dugan, D. M. Turetsky, C. Du, D. Lobner, M. Wheeler, C. R. Almli, C. K-F. Shen, T-Y. Luh, D. W. Choi and T-S. Lin, ‘Carboxyfullerenes as neuroprotective agents’, Proc. Natl. Acad. Sci. USA 94 (1997) 9434.
The Human Genome’, Science,February 16, 2001. (http://www.sciencemag.org/genome2001/1153. html).
S. Hunt and F. Livesey, `Functional Genomics: A Practical Approach’, edited by (Oxford University Press, 2000 ).
S. Pennington and M. Dunn, `Proteomics: From Protein Structure to Function’, ( Springer-Verlag, 2000 ).
M. N. Murray, `New Drug Discovery Technologies: Opportunities Created by the Revolution in Genomics’, Lehman Brothers Report, March 11, 1997.
A. Hirsch, `The Chemistry of the Fullerenes’, ( George Thieme Verlag, NY, 1994 ).
S. R. Wilson and D. I. Schuster, `Organic Chemistry of Fullerenes’, in `The Fullerene Handbook’, edited by K. Kadish, and R. Ruoff (John Wiley & Sons, NY, 2000 ).
S. R. Wilson, `The Potential of Fullerenes in Biology and Medicine’, Proc. Electrochem. Soc. 97–42 (1997) 321.
N. Nakajima, C. Nishi, F-M. Li and Y. Ikada, `Photo-induced cytotoxicity of water-soluble fullerene’, Fullerene Sci. Technol. 4 (1) (1996) 1–19.
A. N. Kirschner and S. R. Wilson, `A Biosensor for Fullerenes and Nanotubes’, Foresight Proceedings, (http://www.foresight.org/Conferences/MNT8/Papers/ Wilson/index.html).
A. N. Kirschner, D. H. Santosa and S. R. Wilson, `Liposomes vs Carbon Nanotubes as Small Molecule Vessels for Drug Delivery’, Electrochem. Soc. Proc. 2000–11, (2000) 250.
R. C. Richmond and U. J. Gibson, `Fullerene coated surfaces and uses thereof’, US Patent 5,310, 669 (1994).
D. B. Warheit, J. F. Hansen, M. C. Carakostas and M. A. Hartsky, `Acute inhalation toxicity studies on rats with a respirable-sized experimental carbon fiber: pulmonary biochemical and cellular effects’, Ann. Occup. Hygiene 38 (1994) 769–776.
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Wilson, S.R. (2002). Nanomedicine: Fullerene and Carbon Nanotube Biology. In: Ōsawa, E. (eds) Perspectives of Fullerene Nanotechnology. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9598-3_14
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DOI: https://doi.org/10.1007/978-94-010-9598-3_14
Publisher Name: Springer, Dordrecht
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