Skip to main content

Diagnosis of Hyperlipidaemia

  • Chapter
Lipids: A Clinicians’ Guide

Abstract

There are 5 main groups of individuals who deserve consideration for lipid testing:

  1. 1)

    Those with symptomatic vascular disease

  2. 2)

    Those with upper abdominal pain and/or pancreatitis

  3. 3)

    Those with metabolic conditions associated with secondary hyperlipidaemia

  4. 4)

    Those with other cardiovascular risk factors

  5. 5)

    Asymptomatic individuals.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Goldstein, J.L.; Hazzard, W.R.; Schrott, H.G.; Biermann, E.L. and Motulsky, A.G.: Hyperlipidemia in coronary heart disease. I. Lipid levels in 500 survivors of myocardial infarction. Journal of Clinical Investigation 52: 1533–1543 (1973).

    Article  PubMed  CAS  Google Scholar 

  2. Calvert, G.D.; Graham, J.J.; Mannik, T.; Wise, P.H. and Yeates, R.A.: Effects of therapy on plasma-high-density-lipoprotein cholesterol concentration in diabetes mellitus. The Lancet 2: 66–68 (1968).

    Google Scholar 

  3. Ibels, L.S.; Simons, L.A.; King, J.O.; Williams, P.F.; Neale, F.C. and Stewart, J.H.: Studies in the nature and causes of hyperlipidaemia in uraemia, maintenance dialysis and renal transplantation. Quarterly Journal of Medicine 44: 601–614 (1975).

    PubMed  CAS  Google Scholar 

  4. Lasser, U.L.; Burns, B. and Solar, S.: Type III hyperlipoproteinemia secondary to hypothyroidism; in Schettler and Weizel (Eds) Atherosclerosis III, p.621–625 (Springer-Verlag, Berlin 1974).

    Chapter  Google Scholar 

  5. Wallace, R.B.; Hoover, J.; Sandler, D.; Rifkind, B.M. and Tyroler, H.A.: Altered plasma lipids associated with oral contraceptive or oestrogen consumption. The Lancet 2: 11–14 (1977).

    Article  CAS  Google Scholar 

  6. Bradley, D.D.; Wingerd, J.; Petitti, D.B.; Krauss, R.M. and Ramcharan, S.: Serum high-densitylipoprotein cholesterol in women using oral contraceptives, estrogens, and progestins. The New England Journal of Medicine 299: 17–20 (1978).

    Article  PubMed  CAS  Google Scholar 

  7. Fredrickson, D.S. and Lees, R.S.: A system for phenotyping hyperlipoproteinemia. Circulation 31: 321–327 (1975).

    Google Scholar 

  8. Brunzell, J.D.; Chait, A. and Bierman, E.L.: Pathophysiology of lipoprotein transport. Metabolism 27: 1109–1127 (1978).

    Article  PubMed  CAS  Google Scholar 

  9. Breckenridge, W.C.; Little, J.A.; Steiner, G.; Chow, A. and Poapst, M.: Hypertriglyceridemia associated with deficiency of apolipoprotein C-II. The New England Journal of Medicine 298: 1266–1273 (1978).

    Article  Google Scholar 

  10. Lieber, C.S.: Effects of ethanol upon lipid metabolism. Lipids 9: 103–116 (1974).

    Article  PubMed  CAS  Google Scholar 

  11. Glueck, C.J.; Fallat, R.W. and Scheel, D.: Effects of estrogenic compounds on triglyceride kinetics. Metabolism 24: 537–545 (1975).

    Article  PubMed  CAS  Google Scholar 

  12. Ibels, L.S.; Reardon, M.F. and Nestel, P.J.: Plasma postheparin lipolytic activity and triglyceride clearance in uremic and hemodialysis patients and renal allograft recipients. Journal of Laboratory and Clinical Investigation 87: 648–658 (1976).

    CAS  Google Scholar 

  13. Pykalistu, O.J.; Smith, P.H. and Brunzell, J.D.: Determinants of human adipose tissue lipoprotein lipase. Effect of diabetes and obesity on basal and diet-induced activities. Journal of Clinical Investigation 56: 1108–1117 (1975).

    Article  Google Scholar 

  14. Simons, L.A.; Williams, P.F. and Turtle, J.R. Type V hyperlipoproteinaemia revisited: Findings in a Sydney population. The Australian and New Zealand Journal of Medicine 5: 210–219 (1975).

    Article  CAS  Google Scholar 

  15. Simons, L.A.; Reichl, D.; Myant, N.B. and Mancini, M.: The metabolism of the apoprotein of plasma low density lipoprotein in familial hyperbetalipoproteinemia in the homozygous form. Atherosclerosis 21: 283–298 (1975).

    Article  PubMed  CAS  Google Scholar 

  16. Goldstein, J.L. and Brown, M.S.: The low-density lipoprotein pathway and its relation to atherosclerosis. Annual Review of Biochemistry 46: 897–930 (1977).

    Article  PubMed  CAS  Google Scholar 

  17. Albers, J.J.; Warnick, G.R. and Hazzard, W.R.: Type III hyperlipoproteinemia: A comparative study of current diagnostic techniques. Clinica Chimica Acta 75: 193–203 (1977).

    Article  CAS  Google Scholar 

  18. Chait, A.; Hazzard, W.R.; Albers, J.J.; Kushwaha, R.P. and Brunzell, J.D.: Impaired very low density lipoprotein and triglyceride removal in broad beta disease: Comparison with endogenous hypertriglyceridemia. Metabolism 27: 1055–1066 (1978).

    Article  PubMed  CAS  Google Scholar 

  19. Simons, L.A. and Jones, A.S.: Coronary risk factor screening and long term follow-up. Year 1 of the Sydney Coronary Heart Disease Prevention Programme. Medical Journal of Australia 2: 455–458 (1978).

    PubMed  CAS  Google Scholar 

  20. Welborn, T.A.; Murphy, B.P.; Stewart, A.J.; Fullerton, R. and Finch, P.S.: Prevalence of cardiovascular risk factors including fasting serum triglyceride levels in the Cunderdin Health Survey of 1971. Medical Journal of Australia 2: 199–204 (1976).

    PubMed  CAS  Google Scholar 

  21. Nestel, P.J.; Quinlivan, N. and Roxburgh, H.: Possible usefulness of screening for hyperlipidaemia. Medical Journal of Australia 2: 203–205 (1977).

    PubMed  CAS  Google Scholar 

  22. Lewis, B.; Chait, A.; Wootton, I.D.P.; Oakley, CM.; Krikler, D.M.; Sigurdsson, G.; February, A.; Maurer, B. and Birkhead, J.: Frequency of risk factors for ischaemic heart disease in a healthy British population with particular reference to serum lipoprotein levels. Lancet 1: 141–146 (1974).

    Article  PubMed  CAS  Google Scholar 

  23. Leren, P. and Haabrekke, O.: Blood lipids in normals. Acta Medica Scandinavica 189: 501–504 (1971).

    Article  PubMed  CAS  Google Scholar 

  24. Wood, P.D.S.; Stern, M.P.; Silvers, A.; Reaven, G. and von der Groeben, J.: Prevalence of plasma lipoprotein abnormalities in free-living population of the Central Valley, California. Circulation 45: 114–126 (1972).

    PubMed  CAS  Google Scholar 

  25. Luepker, R.V.; Kent Smith, L.; Gillis, A.; Kochman, L.; Warbasse, R. and Sherwin, R.: Serum lipid levels in a clerical workforce. Journal of Chronic Diseases 30: 547–555 (1977).

    Article  PubMed  CAS  Google Scholar 

  26. Tibblin, G. and Kramer, K.: Serum lipids during the course of an acute myocardial infarction and one year afterwards. Acta Medica Scandinavica 174: 451–455 (1963).

    Article  PubMed  CAS  Google Scholar 

  27. Williams, P.F.; Simons, L.A. and Turtle, J.R.: Plasma lipoproteins in pregnancy. Hormone Research 7: 83–90 (1976).

    Article  PubMed  CAS  Google Scholar 

  28. Ames, R. and Hill, P.: Elevation of serum lipid levels during diuretic therapy of hypertension. American Journal of Medicine 61: 748–757 (1976).

    Article  PubMed  CAS  Google Scholar 

  29. Tanaka, N.; Sakaguchi, S.; Oshige, K.; Niimura, T. and Kanehisa, T.: Effect of chronic administration of Propranolol on lipoprotein composition. Metabolism 25: 1071–1075 (1976).

    Article  PubMed  CAS  Google Scholar 

  30. El-Shaboury, A.H. and Hayes, T.M.: Hyperlipidemia in asthmatic patients receiving long term steroid therapy. British Medical Journal 2: 85–86 (1973).

    Article  PubMed  CAS  Google Scholar 

  31. Zak, B.: Cholesterol methodologies: A review. Clinical Chemistry 23: 1201–1214 (1977):.

    PubMed  CAS  Google Scholar 

  32. Carter, T. and Wilding, P.: Factors involved in the determination-of triglycerides in serum: an international study. Clinica Chimica Acta 70: 433–447 (1976).

    Article  CAS  Google Scholar 

  33. Burstein, M.; Scholnick, H.R. and Morfin, R.: Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions. Journal of Lipid Research 11: 583–595 (1970).

    PubMed  CAS  Google Scholar 

  34. Finley, P.R.; Schifman, R.B.; Williams, J. and Lichti, D.A.: Cholesterol in high density lipoprotein: use of Mg+2/dextran sulfate in its enzymic measurement. Clinical Chemistry 24: 931–933 (1978).

    PubMed  CAS  Google Scholar 

  35. Albers, J.J.; Warnick, G.R.; Wiebe, D.; King, P.; Steiner, P.; Smith, L.; Breckenridge, C.; Chow, A.; Kuba, K.; Weidman, S.; Arnett, H.; Wood, P. and Schlagenhaft, A.: Multi-laboratory comparison of three heparin-Mn2+ precipitation procedures for estimating cholesterol in high density lipoprotein. Clinical Chemistry 24: 853–856 (1978).

    PubMed  CAS  Google Scholar 

  36. Lindgren, F.T.; Jensen, L.C. and Hatch, F.T.: The isolation and quantitative analysis of serum lipoproteins; in Nelson (Ed) Blood Lipids and Lipoproteins: Quantitation, Composition and Metabolism, p. 181–274 (Wiley Interscience, New York 1972).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1980 ADIS Press Australasia Pty Ltd.

About this chapter

Cite this chapter

Simons, L.A., Gibson, J.C. (1980). Diagnosis of Hyperlipidaemia. In: Lipids: A Clinicians’ Guide. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9464-1_4

Download citation

  • DOI: https://doi.org/10.1007/978-94-010-9464-1_4

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-0-85200-511-8

  • Online ISBN: 978-94-010-9464-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics