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Experimental protoporphyria in hairless mice: photohaemolysis versus Photodermatitis

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Inflammation: Mechanisms and Treatment

Part of the book series: Inflammation: Mechanisms and Treatment ((FTIN,volume 4))

Abstract

In 1908 Hausmann1 proved that systemically administered haematoporphyrin might be fatal for mice if they were exposed to violet light, while a much larger dose of this substance was harmless if the animals were kept in the dark. Meyer-Betz2 injected himself with haematoporphyrin which resulted in marked erythema and oedema of the light exposed parts of the body. In spite of this recognized relation between porphyrins and photosensitivity the pathogenesis of the dermatitis of patients who suffer from photosensitive porphyria is not fully understood.

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Authors and Affiliations

  1. Netherlands

    R. A. Woutersen, C. W. M. Van Holsteijn & H. Baart De La Faille

Authors
  1. R. A. Woutersen
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  2. C. W. M. Van Holsteijn
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  3. H. Baart De La Faille
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Editor information

Editors and Affiliations

  1. Department of Experimental Pathology and Rheumatology, St Bartholomew’s Hospital, London, UK

    D. A. Willoughby (Professor) (Professor)

  2. Department of Pharmacology, Hôpital Cochin, Paris, France

    J. P. Giroud (Professor) (Professor)

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© 1980 MTP Press Limited

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Woutersen, R.A., Van Holsteijn, C.W.M., De La Faille, H.B. (1980). Experimental protoporphyria in hairless mice: photohaemolysis versus Photodermatitis. In: Willoughby, D.A., Giroud, J.P. (eds) Inflammation: Mechanisms and Treatment. Inflammation: Mechanisms and Treatment, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9423-8_88

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  • DOI: https://doi.org/10.1007/978-94-010-9423-8_88

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-9425-2

  • Online ISBN: 978-94-010-9423-8

  • eBook Packages: Springer Book Archive

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