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Immunological Aspects of Cancer pp 123–154Cite as

Macrophages and cancer

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Abstract

Since its relatively recent promotion from the ranks of scavenger, the full range of known and possible mononuclear phagocyte functions in host defence has been the subject of many reviews and books1-8, and is quite beyond the scope of this article. A brief survey only will be given, therefore, of the properties of macrophages in so far as they may relate to immunological and non-immunological host defence mechanisms against cancer. First it is necessary to define our terms of reference:

Macrophages represent the differentiated tissue phase of a mononuclear phagocyte system9 (MPS) which includes their immediate precursors, the blood monocytes, and the promonocytes of the bone marrow, and it is to these three main classes of cells that I shall be referring. Functional properties by which these cells can be readily distinguished include strong adherence to glass, immune phagocytosis and several others described by Lejeune3.

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References

  1. Vernon-Roberts, V. (1972). The Macrophage. (London and New York: Cambridge University Press)

    Google Scholar 

  2. Alexander, P. (1975). The role of macrophages in the host defence against cancer. In: Host Defence against Cancer and its Potentiation (D. Mizuno et al; eds.), p. 113. (Baltimore: University of Tokyo Press)

    Google Scholar 

  3. Lejeune, F. J. (1975). The role of macrophages in immunity with special reference to tumour immunology. A review. Biomedicine, 22, 25

    PubMed  CAS  Google Scholar 

  4. Carr, L (1973). The Macrophage: A Review of Structure and Function. (London: Academic Press)

    Google Scholar 

  5. Evans, R. (1975). Macrophage cytotoxicity. In: Mononuclear Phagocytes in Immunity, Infection and Pathology (R. van Furth; ed.), 2nd Conference on mononuclear phagocytes. (London: Blackwell Scientific Publications)

    Google Scholar 

  6. Levy, M. H. and Wheelock, E. F. (1974). The role of macrophages in defence against neoplastic disease. Adv. Cancer Res., 20,131

    PubMed  CAS  Google Scholar 

  7. Nelson, D. S. (1974). Immunity to infection, allograft immunity and tumour immunity: parallels and contrasts. Transplant. Rev., 19, 226

    PubMed  CAS  Google Scholar 

  8. Nelson, D. S. (1969). In:Macrophages and Immunity (A. Neuberger and E. L. Tatum; eds.), Frontiers of Biology Vol. 11. (Amsterdam: North-Holland)

    Google Scholar 

  9. van Furth, R., Cohn, Z. A., Hirsch, J. G. et al (1972). The mononuclear phagocyte system: a new classification of macrophages, monocytes and their precursor cells. Bull. Wld. Health Org., 46, 845

    Google Scholar 

  10. Möller, G. and Möller, E. (1976). The concept of immunological surveillance against neoplasia. Transplant. Rev., 28, 3

    PubMed  Google Scholar 

  11. Territo, M. C. and Cline, M. J. (1975). Mononuclear phagocyte proliferation, maturation and function. Clin. Haematol., 4, 685

    PubMed  CAS  Google Scholar 

  12. Evans, R. and Alexander, P. (1976). Mechanisms of extracellular killing of nucleated mammalian cells by macrophages. In: Immunobiology of the Macrophage (D. S. Nelson; ed.), p. 353. (New York: Academic Press)

    Google Scholar 

  13. Mantovani, B., Rabinovitch, M. and Nussenzweig, V. (1972). Phagocytosis of immune complexes by macrophages. J. Exp. Med., 135, 780

    PubMed  CAS  Google Scholar 

  14. Davies, P. and Allison, A. C. (1976). Secretion of macrophage enzymes in relation to the pathogenesis of chronic inflammation. In: Immunobiology of the Macrophage (D. S. Nelson; ed.), p. 428. (New York: Academic Press)

    Google Scholar 

  15. Currie, G. A. and Eccles, S. A. (1976). Serum lysozyme as a marker of host resistance. (1) Production by macrophages resident in rat sarcomata. Br. J. Cancer, 33, 51

    PubMed  CAS  Google Scholar 

  16. Snyderman, R. and Mergenhagen, S. E. (1976). Chemotaxis of macrophages. In: Immunobiology of the Macrophage (D. S. Nelson; ed.), p. 323. (New York: Academic Press)

    Google Scholar 

  17. Hirsch, J. G. (1975). The phagocytic cell in host resistance: a perspective summation. In: The Phagocytic Cell in Host Resistance (J. A. Bellanti and D. H. Dayton; eds.). (New York: Raven Press)

    Google Scholar 

  18. Spector, W. G., Walters, N. M-L, and Willoughby, D. A. (1965). The origin of mononuclear cells in inflammatory exudates induced by fibrinogen. J. Pathol. BacterioL, 90, 181

    PubMed  CAS  Google Scholar 

  19. Bosman, C. and Feldman, J. D. (1970). Composition, morphology and source of cells in delayed skin reactions. Am. J. Pathol, 58, 201

    PubMed  CAS  Google Scholar 

  20. Loor, F. and Roelants, G. E. (1974). The dynamic state of the macrophage plasma membrane. Attachment and fate of immunoglobulin, antigen and lectins. Eur. J. Immunol, 4, 649

    PubMed  CAS  Google Scholar 

  21. Basten, A. and Mitchell, J. (1975). Role of macrophages in T cell B cell collaboration in antibody production. In: Immunobiology of the Macrophage (D. S. Nelson; ed.), p. 45. (New York: Academic Press)

    Google Scholar 

  22. Argyris, B. F. (1968). Role of macrophages in immunological maturation. J. Exp. Med., 129, 459

    Google Scholar 

  23. David, J. R. (1975). A brief review of macrophage activation by lymphocyte mediators. In: The Phagocytic Cell in Host Resistance (J. A. Bellanti and D. H. Dayton; eds.), p. 143. (New York: Raven Press)

    Google Scholar 

  24. Feldman, M. and Nossal, G. J. V. (1972). Tolerance, enhancement and the regulation of interactions between T cells, B cells and macrophages. Transplant. Rev., 13, 3

    Google Scholar 

  25. Rhodes, J. (1975). Macrophage heterogeneity in receptor activity: the activation of macrophage Fc receptor function in vivo and in vitro. J. Immunol, 114, 976

    CAS  Google Scholar 

  26. Cardella, C. J., Davies, P. and Allison, A. C. (1974). Immune complexes induce selective release of lysosomal hydrolases from macrophages. Nature (London), 247, 46

    CAS  Google Scholar 

  27. Huber, H. and Fudenberg, H. H. (1970). The interactions of monocytes and macrophages with immunoglobulins and complement. Ser. Haematol, 3, 175

    Google Scholar 

  28. Keller, R. (1976). Cytostatic and cytocidal effects of activated macrophages. In: Immunobiology of the Macrophage (D. S. Nelson; ed.), p. 487. (New York: Academic Press)

    Google Scholar 

  29. Lohmann-Matthes, M-L. (1976). Induction of macrophage-mediated cytotoxicity. In: Immunobiology of the Macrophage (D. S. Nelson; ed.), p. 464. (New York: Academic Press)

    Google Scholar 

  30. Keller, R. (1974). Mechanisms by which activated normal macrophages destroy syngeneic rat tumour cells in vitro—cytokinetics, non-involvement of T lymphocytes and effect of metabolic inhibitors. Immunology, 27, 285

    PubMed  CAS  Google Scholar 

  31. Kirschner, H., Holden, H. T. and Herberman, R. B. (1975). Inhibition of in vitro growth of lymphoma cells by macrophages from tumour-bearing mice. J. Nat. Cancer Inst., 55, 971

    Google Scholar 

  32. Hibbs, J. B., Lambert, L. H. and Remington, J. S. (1972). Macrophage mediated nonspecific cytotoxicity—possible role in tumour resistance. Nature New Biol, 235, 48

    PubMed  Google Scholar 

  33. Cleveland, R. P., Meitzer, M. S. and Zbar, B. (1974). Tumour cytotoxicity in vitro by macrophages from mice infected with Mycobacterium bovis strain BCG. J. Nat. Cancer Inst., 52, 1887

    PubMed  CAS  Google Scholar 

  34. Currie, G. A. and Basham, C. (1975). Activated macrophages release a factor which lyses malignant but not normal cells. J. Exp. Med., 142, 1600

    PubMed  CAS  Google Scholar 

  35. Calderon, J., Williams, R. T. and Unanue, E. R. (1974). An inhibitor of ceU proliferation by cultures of macrophages. Proc. Nat. Acad. Sci. U.S. A., 71, 4273

    CAS  Google Scholar 

  36. Sethi, K. K. and Brandis, H. (1975). Cytotoxicity mediated by soluble macrophage products, y. Nat. Cancer Inst., 55, 393

    CAS  Google Scholar 

  37. Currie, G. A. (1976). Immunological aspects of host resistance to the development and growth of cancer. Biochim. Biophys. Acta, 458, 135

    PubMed  CAS  Google Scholar 

  38. Harmel, R. P. and Zbar, B. (1975). Tumor suppression by pyran copolymer: correlation with production of cytotoxic macrophages. J. Nat. Cancer Inst., 54, 989

    PubMed  CAS  Google Scholar 

  39. Keller, R. and Jones, V. E. (1971). Role of activated macrophages and antibody in inhibition and enhancement of tumour growth in rats. Lancet, ii, 847

    Google Scholar 

  40. Droller, M. J. and Remington, J. S. (1975). A role for the macrophage in in vivo andin vitro resistance to murine bladder tumour cell growth. Cancer Res., 35, 49

    PubMed  CAS  Google Scholar 

  41. Evans, R. (1975). Macrophage-mediated cytotoxicity—its possible role in rheumatoid arthritis, Ann. NY. Acad. Sci., 256, 275

    PubMed  CAS  Google Scholar 

  42. Haskill, J. S., Proctor, J. W. and Yamamura, Y. (1975). Host responses within solid tumours. 1. Monocytic effector cells within rat sarcomas. J. Nat. Cancer Inst., 54, 387

    PubMed  CAS  Google Scholar 

  43. van Loveren, H. and Den Otter, W. (1974). Macrophages in soHd tumours. 1. Immunologically specific effector cells. J. Nat. Cancer Inst., 53, 1057

    PubMed  Google Scholar 

  44. Boyle, M. D. P. and Ormerod, M. G. (1975). The destruction of allogeneic tumour cells by peritoneal macrophages derived from immune mice: purification of lytic effector cells. Cell. Immunol, 17, 247

    PubMed  CAS  Google Scholar 

  45. Evans, R. and Alexander, P. (1971). Rendering macrophages specifically cytotoxic by a factor released from immune lymphoid cells. Transplantation, 12, 227

    PubMed  CAS  Google Scholar 

  46. Evans, R. and Alexander, P. (1970). Co-operation of immune lymphoid cells with macrophages in tumour immunity. Nature (London), 228, 620

    CAS  Google Scholar 

  47. Alexander, P., Evans, R. and Mikulska, Z. B. (1973). Relationship between concomitant immunity and metastasis. The role of macrophages in concomitant immunity involving the peritoneal cavity. In: Chemotherapy of Cancer Dissemination and Metastasis (S. Garattini and G. Franchi; eds.), p. 170. (New York: Raven Press)

    Google Scholar 

  48. Jolley, G. H., Boyle, M. D. P. and Ormerod, M. G. (1976). The destruction of allogeneic tumour cells by antibody and adherent cells from the peritoneal cavities of mice. Cell Immunol, 22, 262

    PubMed  CAS  Google Scholar 

  49. Shin, H. S., Kaliss, N., Borenstein, D. and Gately, M. K. (1972). Antibody-mediated suppression of grafted lymphoma cells. II. Participation of macrophages. J. Exp. Med., 136, 375

    PubMed  CAS  Google Scholar 

  50. Fisher, B., Wolmark, N., Coyle, J. and Saffer, E. A. (1976). The effect of a growing tumour and its removal on the cytotoxicity of macrophages from cultured bone marrow cells. Cancer Res., 36, 2302

    PubMed  CAS  Google Scholar 

  51. Grant, C. K., Currie, G. A. and Alexander, P. (1972). Thymocytes from mice immunized against an allograft render bone marrow cells specifically cytotoxic. J. Exp. Med., 135, 150

    PubMed  CAS  Google Scholar 

  52. Holterman, O. A., Djerassi, I., Lisafield, B. A., Elias, E. G., Papermaster, B. W. and Klein, E. (1974). In vitro destruction of tumour cells by human monocytes. Proc. Soc. Exp. Biol Med., 147, 456

    Google Scholar 

  53. Sanford, B. H., Kohn, H. I., Daly, J. J. and Soo, S. F. (1973). Long-term spontaneous tumour incidence in neonatally thymectomised mice. J. Immunol, 110, 1437

    PubMed  CAS  Google Scholar 

  54. Stutman, O. (1974). Tumour development after 3-methylcholanthrene in immunologically deficient athymic-nude mice. Science, 183, 534

    PubMed  CAS  Google Scholar 

  55. Schwartz, R. S. (1975). Another look at immunologic surveillance. New Engl J. Med., 38, 131

    Google Scholar 

  56. Stjemsward, J. (1972). Introduction: modification of immunity and carcinogenesis. Nat. Cancer Inst. Monog., 35, 149

    Google Scholar 

  57. Hibbs, J. B., Lambert, L. H. and Remington, J. S. (1972). Non-immunological destruction of cells with abnormal growth characteristics by activated macrophages. Proc. Soc. Exp. Biol. Med., 139, 1049

    PubMed  Google Scholar 

  58. Holtermann, O. A., Klein, E. and Casale, G. P. (1973). Selective cytotoxicity of peritoneal leucocytes for neoplastic cells. Cell. Immunol., 9, 339

    PubMed  CAS  Google Scholar 

  59. Hibbs, J. B. (1973). Macrophage non-immunological recognition: target cell factors related to contact inhibition. Science, 180, 868

    PubMed  Google Scholar 

  60. Alexander, P. (1976). Surveillance against neoplastic cells. Is it mediated by macrophages? Br. J. Cancer, 33, 344

    PubMed  CAS  Google Scholar 

  61. Baldwin, R. W. (1976). Role of immunosurveillance against chemically-induced rat tumours. Transplant. Rev., 28, 62

    PubMed  CAS  Google Scholar 

  62. Keller, R. (1974). Modulation of cell proliferation by macrophages. A possible function apart from cytotoxic tumour rejection. Br. J. Cancer, 30, 401

    PubMed  CAS  Google Scholar 

  63. Keller, R. (1976). Susceptibility of normal and transformed cell lines to cytostatic and cytocidal effects exerted by macrophages. J. Nat. Cancer Inst., 56, 369

    PubMed  CAS  Google Scholar 

  64. Alexander, P. (1976). The functions of the macrophage in malignant disease. Annu. Rev. Med., 27, 207

    PubMed  CAS  Google Scholar 

  65. Hibberd, A. D. and Metcalf, D. (1971). Proliferation of macrophage and granulocyte precursors in response to primary and transplanted tumours. Isr. J. Med. Sci., 7, 202

    PubMed  CAS  Google Scholar 

  66. Eccles, S. A., Bandlow, G. and Alexander, P. (1976). Monocytosis associated with the growth of transplanted syngeneic rat sarcomata differing in immunogenicity. Br. J. Cancer, 34, 20

    PubMed  CAS  Google Scholar 

  67. Blamey, R. W., Crosby, D. L. and Baker, J. M. (1969). Reticulo-endothelial activity during the growth of rat sarcomas. Cancer Res.,29, 335

    PubMed  CAS  Google Scholar 

  68. Magarey, C. J. and Baum, M. (1970). Reticulo-endothelial activity in humans with cancer. Br. J. Surg., 57, 748

    PubMed  CAS  Google Scholar 

  69. Nelson, D. S. and Kearney, R. (1976). Macrophage and lymphoid tissues in mice with concomitant tumour immunity. Br. J. Cancer, 34, 221

    PubMed  CAS  Google Scholar 

  70. Underwood, J. C. E. (1974). Lymphoreticular infiltration in human tumours: prognostic and biological implications, a review. Br. J. Cancer, 30, 538

    PubMed  CAS  Google Scholar 

  71. Evans, R. (1972). Macrophages in syngeneic animal tumours. Transplantation, 14, 468

    PubMed  CAS  Google Scholar 

  72. Black, M. M. and Speer, F. D. (1958). Sinus histiocytosis of lymph nodes in cancer. Surg. Gynecol. Obstet., 106, 163

    PubMed  CAS  Google Scholar 

  73. Isa, A. M. and Sanders, B. R. (1975). Enhancement of tumour growth in allogeneic mice following impairment of macrophage function. Transplantation, 20, 296

    PubMed  CAS  Google Scholar 

  74. Bernstein, I. D., Thor, D. E., Zbar, B. and Rapp, H. J. (1971). Tumor immunity. Tumor suppression in vivo initiated by soluble products of specifically stimulated lymphocytes. Science, 172, 729

    PubMed  CAS  Google Scholar 

  75. Snodgrass, M. J. and Hanna, M. G. (1973). Ultrastructural studies of histiocyte-tumor cell interactions during tumour regression after intralesional injection of Mycobacterium bovis. Cancer Res., 33, 701

    CAS  Google Scholar 

  76. Mansell, P. W. A., Inchinose, H., Reed, R. J., Krementz, E. T., McNamee, R. and Di Luzio, N. R. (1975). Macrophage-mediated destruction of human malignant cells in vivo. J. Nat. Cancer Inst., 54, 571

    PubMed  CAS  Google Scholar 

  77. Papermaster, P. W., Holtermann, O. A., Rosner, D., Klein, E. and Dao, T. (1974). Regressions induced in breast cancer lesions by a lymphokline fraction from a human lymphoid cell line. Res. Comm. Chem. Pathol. Pharmacol, 8, 413

    CAS  Google Scholar 

  78. Levy, M. H. and Wheelock, F. E. (1975). Effects of intravenous silica on immune and nonimmune functions of the murine host. J. Immunoly 115, 41

    CAS  Google Scholar 

  79. Stutman, O. (1975). Delayed tumour appearance and absence of regression in nude mice infected with murine sarcoma virus. Nature (London), 235, 142

    Google Scholar 

  80. Russell, S. W., Doe, W. F. and Cochrane, C. G. (1976). Number of macrophages and distribution of mitotic activity in regressing and progressing Moloney sarcomas. J. Immunol, 116, 164

    Google Scholar 

  81. Haskill, J. S., Yamamura, Y. and Radov, L. (1975). Host response within solid tumours: non-thymus derived specifically cytotoxic cells within a murine mammary adenocarcinoma. Int. J. Cancer, 16, 798

    PubMed  CAS  Google Scholar 

  82. Eccles, S. A. and Alexander, P. (1974). Macrophage content of tumours in relation to metastatic spread and host immune reaction. Nature (London), 250, 667

    CAS  Google Scholar 

  83. Alexander, P., Eccles, S. A. and Gauci, C. L. L. (1976). The significance of macrophages in human and experimental tumours. Ann. NY. Acad. Set. U.S.A., 276, 124

    CAS  Google Scholar 

  84. Ptak, W. and Gershon, R. K. (1975). Inmiunosuppression effected by macrophage surfaces. J. Immunol, 115, 1346

    PubMed  CAS  Google Scholar 

  85. Hersey, P. and MacLennan, I. C. M. (1973). Macrophage-dependent protection of tumour cells. Immunology, 24, 385

    PubMed  CAS  Google Scholar 

  86. Carter, R. L. (1975). Immunological control of metastatic growth. In: Host Defence in Breast Cancer (B. A. Stoll; ed.). New Aspects of Breast Cancer 1, p. 6. (London: Heineman)

    Google Scholar 

  87. Birbeck, M. S. C. and Carter, R. L. (1972). Observations on the ultrastructure of two hamster lymphomas with particular reference to infiltrating macrophages. Int. J. Cancer, 9, 249

    PubMed  CAS  Google Scholar 

  88. Kim, U. (1970). Metastasizing mammary carcinomas in rats: induction and study of their immunogenicity. Science, 167, 72

    PubMed  CAS  Google Scholar 

  89. Proctor, J. W., Rudenstam, C-M. and Alexander, P. (1973). A factor preventing the development of lung metastases in rats with sarcomas. Nature (London), 242, 29

    CAS  Google Scholar 

  90. Camaud, C., Hoch, B. and Trainin, N. (1974). Influence of immunologic competence of the host on metastases induced by the 3LL Lewis tumor in mice. J. Nat. Cancer Inst., 52, 395

    Google Scholar 

  91. Weston, B. J., Carter, R. L., Easty, G. C., Connell, D. I. and Davies, A. J. S. (1974). The growth and metastasis of an allografted lymphoma in normal, deprived and reconstituted mice. Int, J. Cancer, 14, 176

    CAS  Google Scholar 

  92. Kearney, R., Basten, A. and Nelson, D. S. (1975). Cellular basis for the immune response to methylcholanthrene induced tumors in mice: heterogeneity of effector cells. Int. J. Cancer, 15, 438

    PubMed  CAS  Google Scholar 

  93. Deodhar, S. D. and Crile, G. (1969). Enhancement of metastases by antilymphocyte serum in allogeneic murine tumour system. Cancer Res., 29, 776

    PubMed  CAS  Google Scholar 

  94. Vaage, J. (1973). Humoral and cellular immune factors in the systemic control of artificially induced metastases in C3Hf mice. Cancer Res., 33, 1957

    PubMed  CAS  Google Scholar 

  95. Currie, G. A. and Alexander, P. (1974). Spontaneous shedding of TSTA by viable sarcoma cells: its possible role in facilitating metastatic spread. Br. J. Cancer, 29, 72

    PubMed  CAS  Google Scholar 

  96. Wood, G. W. and Gillespie, G. Y. (1975). Studies on the role of macrophages in regulation of growth and metastasis of murine chemically-induced fibrosarcomas. Int. J. Cancer, 16, 1022

    PubMed  CAS  Google Scholar 

  97. Eccles, S. A. and Alexander, P. (1975). Immunologically mediated restraint of latent tumour metastases. Nature (London), 257, 52

    CAS  Google Scholar 

  98. Baserga, R. and Shubik, P. (1955). Action of cortisone on disseminated tumour cells after removal of the primary growth. Science, 121, 100

    PubMed  CAS  Google Scholar 

  99. Sugarbaker, E. V., Cohen, A. M. and Ketcham, A. S. (1970). Facüitated metastatic distribution of the Walker 256 tumor in Sprague-Dawley rats with hydrocortisone and/or cyclophosphamide. J, Surg. Oncol, 2, 277

    CAS  Google Scholar 

  100. De Cosse, J. J. and Gelfant, S. (1968). Non-cycling tumour cells: mitogenic response to antilymphocyte serum. Science, 162, 698

    Google Scholar 

  101. Currie, G. A. and Gage, J. O. (1973). Influence of tumour growth on the evolution of cytotoxic lymphoid cells in rats bearing a spontaneously metastasising syngeneic fibrosarcoma. Br. J. Cancer, 28, 136

    PubMed  CAS  Google Scholar 

  102. Sparks, F. C., O’Connell, T. X., Lee, Y-T. N. and Breeding, J. H. (1974). BCG therapy given as an adjuvant to surgery; prevention of death from metastases from mammary adenocarcinoma in rats. J. Nat. Cancer Inst., 53, 1825

    PubMed  CAS  Google Scholar 

  103. Liotta, L. A., Kleinerman, J. and Saidel, G. M. (1976). Mechanism of Bacillus Calmetteguerin induced suppression of metastases in a poorly immunogenic fibrosarcoma. Cancer Res., 36, 3255

    PubMed  CAS  Google Scholar 

  104. Proctor, J. W., Rudenstam, C-M. and Alexander, P. (1973). Increased incidence of lung metastases following treatment of rats bearing hepatomas with irradiated tumour cells, and the beneficial effect of Corynebacterium parvum in this system. Biomedicine, 19, 248

    PubMed  CAS  Google Scholar 

  105. Milas, L., Hunter, N., Basic, I. and Withers, H. R. (1974). Protection by Corynebacterium granulosum against radiation-induced enhancement of artificial pulmonary metastases of a murine fibrosarcoma. J. Nat. Cancer Inst., 52, 1875

    PubMed  CAS  Google Scholar 

  106. Perper, R. J., Oronsky, A. L. and Sander, M (1976). The effect of BCG on extravascular mononuclear cell accumulation in vivo. Int. J. Cancer, 17, 670

    CAS  Google Scholar 

  107. Likhite, V. V. (1975). Rejection of mammary adenocarcinoma cell tumors in DBA/2 mice immunocompromised by thymectomy and treatment with antithymocyte serum. J. Immunol, 114, 1736

    PubMed  CAS  Google Scholar 

  108. Currie, G. A. (1976). Serum lysozyme as a marker of host resistance. II. Patients with malignant melanoma, hypernephroma or breast carcinoma. Br. J. Cancer, 33, 593

    PubMed  CAS  Google Scholar 

  109. Franchi, G., Reyers-Degli Innocenti, I., Standen, S. and Garattini, S. (1972). The inhibitory effect of cancer cell dissemination on the phagocytic activity of the reticulo-endothelial system in tumour-bearing mice. J. Reticuloendothelial Soc., 12, 618

    CAS  Google Scholar 

  110. Donovan, A. J. (1967). Reticuloendothelial function in patients with cancer. Am. J. Surg., 114, 230

    Google Scholar 

  111. King, G. W., Bain, G. and LoBuglio, A. F. (1975). The effect of tuberculosis and neoplasia on human monocyte staphylocidal activity. Cell. Immunol, 16, 389

    PubMed  CAS  Google Scholar 

  112. Urbanitz, D., Fechner, I. and Gross, R. (1975). Reduced monocyte phagocytosis in patients with advanced Hodgkin’s disease and lymphosarcoma. Klin. Wschr., 53, 437

    PubMed  CAS  Google Scholar 

  113. Pisano, J. C., Jackson, J. P., Di Luzio, N. R. and Ichinose, H. (1972). Dimensions of humoral recognition factor depletion in carcinomatous patients. Cancer Res., 32, 11

    PubMed  CAS  Google Scholar 

  114. Mitchell, M. S. (1976). Role of ‘suppressor’ T lymphocytes in antibody-induced inhibition of cytophilic antibody receptors. Ann. NY. Acad. ScL, 276, 229

    CAS  Google Scholar 

  115. Svensson, B. O. (1975). Serum factors causing impaired macrophage function in patients with systemic lupus erythematosus. Scand. J. Immunol, 4, 145

    PubMed  CAS  Google Scholar 

  116. Sjögren, H. O., Hellström, I., Bansal, S. C. and Hellström, K. (1971). Suggestive evidence that the blocking antibodies of tumour-bearing individuals may be antigen—antibody complexes. Proc. Nat. Acad. Sci. U.S.A., 68, 1372

    Google Scholar 

  117. Bernstein, I. D., Zbar, B. and Rapp, H. J. (1972). Impaired inflammatory response in tumour-bearing Guinea Pigs. J. Nat. Cancer Inst, 49, 1641

    PubMed  CAS  Google Scholar 

  118. Synderman, R., Pike, M. C., Blaylock, B. L. and Weinstein, P. (1976). Effect of neoplasms on inflammation: depression of macrophage accumulation after tumour implantation. J. Immunol, 116, 585

    Google Scholar 

  119. Eccles, S. A. and Alexander, P. (1974). Sequestration of macrophages in growing tumours and its effect on the immunological capacity of the host. Br. J. Cancer, 30, 42

    PubMed  CAS  Google Scholar 

  120. Johnson, M. W., Maibach, H. I. and Salmon, S. E. (1971). Skin reactivity in patients with cancer: Impaired delayed hypersensitivity or faulty inflammatory response? N. Engl J. Med., 284, 1255

    PubMed  CAS  Google Scholar 

  121. Dizon, Q. and Southam, C. M. (1963). Abnormal cellular response to skin abrasion in cancer patients. Cancer, 16, 1288

    PubMed  CAS  Google Scholar 

  122. Goldsmith, H. S., Levin, A. G. and Southam, C. M. (1965). A study of cellular responses in cancer patients by qualitative and quantitative Rebuck tests. Surg. Forum, 16, 102

    PubMed  CAS  Google Scholar 

  123. Normann, S. J. and Sorkin, E. (1976). Cell-specific defect in monocyte function during tumour growth. J. Nat, Cancer Inst., 57, 135

    Google Scholar 

  124. Wilkinson, P. C. (1976). Cellular and molecular aspects of Chemotaxis of macrophages and monocytes. In: Immunobtology of the Macrophage (D. S. Nelson; ed.), p. 349. (New York: Academic Press)

    Google Scholar 

  125. Ward, P. A. and Till, G. (1975). Two distinct chemotactic factor inactivators in human serum. J. Immunol, 114, 843

    PubMed  Google Scholar 

  126. Ward, P. A. and Berenberg, J. L. (1974). Defective regulation of inflammatory mediators in Hodgkin’s disease. Supernormal levels of chemotactic factor inactivator. N. Engl. J. Med., 290, 76

    PubMed  CAS  Google Scholar 

  127. Brozna, J. P. and Ward, P. A. (1975). Antileukotactic properties of tumour cells. J. Clin. Invest., 56, 616

    PubMed  CAS  Google Scholar 

  128. Synderman, R. and Stahl, C. (1975). Defective immune effector function in patients with neoplastic and immune deficiency diseases. In: The Phagocytic Cell in Host Resistance (J. A. Bellanti and D. H. Dayton; eds.), p. 267. (New York: Raven Press)

    Google Scholar 

  129. Brosman, S., Hausman, M. S. and Shacks, S. J. (1975). Studies on the immune status of patients with renal adenocarcinoma. J. Urol., 114, 375

    PubMed  CAS  Google Scholar 

  130. Hausman, M. S., Brosman, S., Snyderman, R., Mickey, M. R. and Fahey, J. (1975). Defective monocyte function in patients with genitourinary carcinoma. J. Nat. Cancer Inst., 55, 1047

    PubMed  CAS  Google Scholar 

  131. Boetcher, D. A. and Leonard, E. J. (1974). Abnormal monocyte chemotactic response in cancer patients. J. Nat. Cancer Inst., 52, 1091

    PubMed  CAS  Google Scholar 

  132. Snyderman, R. and Pike, M. C. (1976). An inhibitor of macrophage Chemotaxis produced by neoplasms. Science, 192, 370

    PubMed  CAS  Google Scholar 

  133. Fauve, R. M., Hevin, B., Jacob, H., Gaillard, J. A. and Jacob, F. (1974). Anti-inflammatory effects of murine malignant cells. Proc. Nat. Acad. Sci. U.S.A., 71, 4052

    CAS  Google Scholar 

  134. Mowat, A. G. and Baum, J. (1971). Chemotaxis of polymorphonuclear leukocytes from patients with rheumatoid arthritis. J. Clin. Invest., 50, 2541

    PubMed  CAS  Google Scholar 

  135. Harris, J. (1972). Immune deficiency states associated with malignant disease in man. Med. Clin. N. Am., 56, 501

    PubMed  CAS  Google Scholar 

  136. Bolton, P. M., Mander, A. M., Davidson, J. M., James, S. L., Newcombe, R. G. and Hughes, L. E. (1975). Cellular immunity in cancer: Comparison of delayed hypersensitivity skin tests in three common cancers. Br. Med. J., 3, 18

    PubMed  CAS  Google Scholar 

  137. Burdick, J. F., Wells, S. A. and Herberman, R. B. (1975). Immunologic evaluation of patients with cancer by delayed hypersensitivity reactions. Surg. Gynecol. Obstet., 141, 779

    PubMed  CAS  Google Scholar 

  138. Weston, W. L., Dustin, R. D. and Hecht, S. K. (1975). Quantitative assays of human monocyte-macrophage function. J. Immunol. Methods, 8, 213

    PubMed  CAS  Google Scholar 

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Authors
  1. Suzanne A. Eccles
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Editors and Affiliations

  1. Royal Postgraduate Medical School, London, UK

    J. E. Castro

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© 1978 MTP Press Limited

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Eccles, S.A. (1978). Macrophages and cancer. In: Castro, J.E. (eds) Immunological Aspects of Cancer. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9418-4_6

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  • DOI: https://doi.org/10.1007/978-94-010-9418-4_6

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-9420-7

  • Online ISBN: 978-94-010-9418-4

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