Abstract
Immunotherapy has emerged during the 1970s as a promising and important new modality in the strategy of cancer treatment. While immunotherapy is still in its infancy and still largely empirical in design, there have been enough significant clinical benefits to justify optimism that this therapeutic modality will take its place alongside surgery, radiotherapy and chemotherapy as a major approach in the management of cancer patients during the next decade.
Supported by Contract NOl-CB-33888 from the National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014. Drs Gutterman and Mavligit are the recipients of Career Development Awards (CA71007-04 and CA 00130-04, respectively) from the National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014, USA
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References
Klein, G. (1975). The Bertner Foundation Memorial Award Lecture—Immunological surveillance against tumors. In: Immunological Aspects of Neoplasia. The University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, Houston, Texas, p. 25. (Baltimore, Md.: The Williams & Wilkins Company)
Hersh, E. M., Gutterman, J. U. and Mavligit, G. M. (1973). Immunotherapy of cancer in man. Scientific basis and current status. Monograph. (Carl Pochedly; ed.), (Springfield, 111.: Charles C. Thomas, Inc.)
Eilber, F. R. and Morton, D. L. (1970). Impaired immunologic reactivity and recurrences following cancer surgery. Cancer, 25, 362
Alexander, P., Currie, G. A. and Thomson, M. P. (1975). The presence of soluble tumorspecific antigens in the blood of patients and experimental animals with tumors and their role in immunotherapy. In: Immunological Aspects of Neoplasia. The University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, Houston, Texas, p. 403. (Baltimore, Md.: The Williams & Wilkins Company)
Mathé, G. (1971). Active immunotherapy. Adv. Cancer Res., 14, 1
Hersh, E. M., Whitecar, J. P., Jr., McCredie, K. B., Bodey, G. P. and Freireich, E. J. (1971). Chemotherapy, immunocompetence, immunosuppression and prognosis in acute leukemia. N. Eng. J. Med., 285, 1211
Immunopotentiation. (1973). (New York: Associated Scientific Publishers)
Howard, J. G., Biozzi, G., Halpern, B. N., Stiflfel, C. and Mouton, D. (1959). The effect of Mycobacterium tuberculosis (BCG) infection on the resistance of mice of endotoxin and Salmonella enteriditis infection. Br. J. Exp. Pathol, 40, 281
Prager, M. D. and Baechtel, F. S. (1973). Methods for modification of cancer cells to enhance their antigenicity. In: Methods in Cancer Research (H. Busch; ed.), (New York: Academic Press)
Coley, W. B. (1911). A report of recent cases of inoperable sarcoma successfully treated with mixed toxins of erysipelas and bacillus prodigiosus. Surg. Gyn. Obstet., 13, 174
Nauts, H. C., Swift, W. E. and Coley, B. L. (1946). Treatment of malignant tumors by bacterial toxins as developed by the late William B. Coley, M.D.: reviewed in the light of modern research. Cancer Res., 6, 205
Old, L. J., Clarke, D. A. and Benacerraf, S. (1959). Effect of bacillus calmette-guerin infection of transplanted tumors in the mouse. Nature New Biol., 18, 291
Klein, E., Holtermann, O. A., Papermaster, B., Milgrom, H., Rosner, D., Klein, L., Walder, M. J. and Zbar, B. (1973). Immunologic approaches to various types of cancer with the use of BCG and purified protein derivatives. Natl. Cancer Inst. Monogr., 39, 229
Morton, D. L., Eilber, F. R., Malmgren, R. A. and Wood, W. C. (1970). Immunological factors which influence response to immunotherapy in malignant melanoma. Surgery, 68, 158
Mathé, G., Amiel, J. L., Schwarzenberg, L., Schneider, M., Cattan, A., Schlumberger, J. R., Hayat, M. and de Vassal, F. (1969). Active immunotherapy for acute lymphoblastic leukaemia. Lancet, i, 697
Bluming, A. Z., Vogel, C. L., Zeigler, J. L., Mody, N. and Kamya, G. (1972). Immunological effects of BCG in malignant melanoma: two modes of administration compared. Ann. Intern. Med., 76, 405
Gutterman, J. U., Mavligit, G. M., McBride, C. M., Frei, E., III, Freireich, E. J. and Hersh, E. J. (1973). Active immunotherapy with BCG for recurrent malignant melanoma. Lancet, i, 1208
Morton, D. L., Eilber, F. R., Holmes, C., Hunt, J. S., Ketcham, A. S., Silverstein, M. J. and Sparks, F. C. (1974). BCG immunotherapy of malignant melanoma: summary of a seven year experience. Ann. Surg., 180, 635
Gutterman, J. U., Mavligit, G., Gottlieb, J. A., Burgess, M. A., McBride, C. E., Einhorn, L., Freireich, E. J. and Hersh, E. M. (1974). Chemoimmunotherapy of disseminated malignant melanoma with dimethyl triazeno imidazole carboxamide and Bacillus Calmette-Guerin. N. Eng. J. Med., 291, 592
Guerin, C. (1975). The history of BCG. In: BCG Vaccination Against Tuberculosis (S. R. Rosentheal; ed.), p. 48. (Boston: Little, Brown and Company)
Mackaness, G. B., Auclair, D. J. and Lagrange, P. H. (1973). Immunopotentiation with BCG. I. Immune response to different strains and preparations. J. Natl. Cancer Inst., 51, 1655
Gutterman, J. U., Hersh, E. M., Rodriguez, V., McCredie, K. B., Mavligit, G., Reed, R., Burgess, M., Gehan, E., Bodey, G. P. and Freireich, E. J. (1974). Chemoimmunotherapy of adult acute leukaemia: prolongation of remission in myeloblastic leukaemia with Bacillus Calmette-Guerin. Lancet, ii, 1405
Sokal, J. E., Aungst, C. W. and Snyderman, M. (1974). Delay in progression of malignant lymphoma after BCG vaccination. N. Engl. J. Med., 291, 1266
Vogler, W. R. and Chan, Y.-K. (1974). Prolonging remission in myeloblastic leukaemia by Tice-Strain Bacillus Calmette-Guerin. Lancet, ii, 128
McKneally, M. F., Maver, C. and Kausel, H. W. (1976). Regional immunotherapy of lung cancer using intrapleural BCG. Lancet, i, 377
Ribi, E. E., Meyer, T. J., Azuma, I. and Zbar, B. (1973). Mycobacterial cell wall components in tumor suppression and regression. Natl. Cancer Inst. Monogr., 39, 115
Lederer, E., Adam, A., Ciorbaru, R., Petit, J. F. and Wietzerbin, J. (1975). Cell walls of mycobacteria and related organisms: chemistry and immunostimulant properties. Mol. Cell Biochem., 7, 87
Yamamura, Y., Yoshizaki, K., Azuma, I., Yagura, T. and Watanabe, T. (1975). Immunotherapy of human malignant melanoma with oil-attached BCG cell wall skeleton. Gann, 66, 355
Feund, J. (1956). The mode of action of immunological adjuvants. Adv. Tuberculosis Res., 7, 130
Weiss, D. W. (1976). M.E.R. and other mycobacterial fractions in the immunotherapy of cancer. Med. Clin. N. Amer., 60, 473
Yamamura, Y. (1977). Immunotherapy of lung cancer with oil-attached cell wall skeleton of BCG: In:Immunotherapy of Cancer: Present Status of Trials in Man. (New York: Raven Press) (In press)
Richman, S. P., Gutterman, J. U., Hersh, E. M. and Price, H. R. (1977). Phase I study of intratumor (TT) immunotherapy with BCG ceU wall skeleton plus P3 (CWS/P3). Proc. Amer. Soc. Clin. Oncol, Abstract 338, 351
Rapp, H. J., Kleinschuster, S. J., Leuker, D. C. and Kainer, R. A. (1976). Immunotherapy of experimental cancer as a guide to the treatment of human cancer. Ann. N., Acad. Sci., 276, 550
Currie, G. A. and Bagshawe, K. (1970). Active immunotherapy with C. parvum and chemotherapy in murine fibrosarcomas. Br. Med. J., i, 541
Milas, L., Gutterman, J. U., Basic, I., Hunter, N., Mavligit, G., Hersh, E. M. and Withers, H. R. (1974). Immunoprophylaxis and immunotherapy for a murine fibrosarcoma with C. granulosum and C. parvum. Int. J. Cancer, 14, 493
Reed, R. C., Gutterman, J. U., Mavligit, G. M., Burgess, M. A. and Hersh, E. M. (1975). Corynebacterium parvum: preliminary report of a Phase I clinical and immunology study in cancer patients. In: Corynebacterium parvum (B. Halper; ed.), p. 349. (New York: Plenum Publishing)
Israel, L. and Edelstein, R. (1975). Nonspecific immunostimulation with Corynebacterium parvum in human cancer. In: Immunological Aspects of Neoplasia. The University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, Houston, Texas, p. 485. (Baltimore, Md.: The Williams & Wilkins, Co.)
Israel, L., Edelstein, R., Depierre, A. and Dimitrov, N. (1975). Brief communication: daily intravenous infusions of Corynebacterium parvum in twenty patients with disseminated cancer: a preliminary report of clinical and biologic findings. J. Natl. Cancer Inst., 55, 29
Gutterman, J., Hersh, E., Benjamin, R., Mavligit, G., Burgess, M. and Bodey, G. (1977). An effective new chemoimmunotherapy regimen for disseminated malignant melanoma (DMM). Proc. Amer. Soc. Clin. Oncol, Abstract 135, 300
Clarkson, B. D., Dowling, M. D., Gee, T. S., Cunningham, I. B. and Burchenal, J. H. (1975). Treatment of acute leukemia in adults. Cancer, 36, 775
Ribi, E., Milner, K. C., Granger, D. L., Kelly, M. T., Yamamoto, K., Brehmer, W., Parker, R., Smith, R. F. and Strain, S. M. (1976). Immunotherapy with nonviable microbial components. Proc. N. Y. Acad. Sci., 277, 228
Carswell, W. A., Old, L. J., Kassel, R. L., Green, S., Fiore, N. and Williamson, B. (1975). An endotoxin-induced serum factor that causes necrosis of tumor. P.N.A.S., 72, 3666
Everall, J. D., O’Donerty, C. J., Wand, J. and Dowd, P. M. (1975). Treatment of primary melanoma by intralesional vaccinia before excision. Lancet, ii, 583
Mansell, P. W. A., Ichinose, H. and Reed, R. J. (1975). Macrophage-mediated destruction of human malignant cells in vivo. J. Natl. Cancer Inst., 54, 571
Chirigos, M. A. (ed.) (1977). Progress in Cancer Research and Therapy. Vol. 2. Control of Neoplasia by Modulation of the Immune System, p. 1. (New York: Raven Press)
Brugmans, J., Schuermans, V., De Cocr, W., Theinpoint, D., Janssen, D., Verhaegen, H., Van Nimmen, L., Louwagie, A. C. and Stevens, D. (1973). Restoration of host defense mechanisms in man by levamisole. Life Sci., 13, 1499
Tripodi, D., Parks, L. C. and Brugmans, J. (1973). Drug-induced restoration of cutaneous delayed hypersensitivity in anergic patients with cancer. N. Eng. J. Med., 289, 354
Amery, W. K. (1976). Double-blind levamisole trial in resectable lung cancer. N., Acad. Sci., 277, 260
Rojas, A., Feirstein, J., Mickiewicz, E., Glait, H. and Olivari, A. J. (1976). Levamisole: clinical action in human breast cancer. Lancet, i, 211
Munder, P. G., Fischer, H., Weltzien, H. U., Oettgen, H. F. and Westphal, O. (1976). Lysolecithin analogs: a new class of immunopotentiators with antitumor activity. Proc. Am. Ass. Cancer Res., 17, 174
Zbar, B., Bernstein, I. D. and Rapp, H. J. (1971). Suppression of tumor grovnh at the site of infection with living Bacillus Calmette-Guerin. J. Natl. Cancer Inst., 46, 831
Gutterman, J. U., Mavligit, G. M., Burgess, M. A., Cardenas, J. O., Blumenschein, G. R., Gottlieb, J. A., McBride, C. M., McCredie, K. B., Bodey, G. P., Rodriguez, V., Freireich, E. J. and Hersh, E. M. (1976). Immunotherapy of human solid tumors and acute leukemia with BCG: prolongation of disease-free interval and survival. Cancer Immunol. Immunother., 1, 99
Eilber, F. R., Morton, D. L., Holmes, E. C., Sparks, F. C. and Ramming, K. P. (1976). Adjuvant immunotherapy with BCG in treatment of regional lymph node mestastases from malignant melanoma. N. Engl. J. Med., 294, 237
Gutterman, J. U., Cardenas, J. O., Blumenschein, G. R., Hortobagyi, G., Livingston, R. B., Mavligit, G. M., Freireich, E. J., Gottlieb, J. A. and Hersh, E. M. (1976). Chemoimmunotherapy of disseminated breast cancer: prolongation of remission and survival. Br. Med. J., ii, 1222
Whittaker, J. A. and Slater, A. J. (1977). The immunotherapy of acute myelogenous leukemia using intravenous BCG. In: Immunotherapy of Cancer: Present Status of Trials in Man. (New York: Raven Press) (In press)
Sokal, J. E., Aungst, C. W., Snyderman, M. and Gomez, G. (1976). Immunotherapy of chronic myelotic leukemia: effects of different vaccination schedules. Ann. N. Y. Acad. Sci., 277, 367
Mathé, G., Amiel, J. L., Halle-Pannenko, O. and Simmler, M. C. (1976). Discussion paper: experimental and clinical immunopharmacology data applicable to cancer immunotherapy. Proc. N. Y. Acad. Sci., 111, 467
Bliznakov, E. H. (1977). Immunostimulation or immunodepression? Biomedicine, 26, 73
Rook, G. A. W. (1975). The immunological consequences of antigen overload in experimental mycobacterial infection of mice. Clin. Exp. Immunol., 19, 167
Verhaegen, H., Verbruggen, F., Verhaegen-Decloercq, M. L. and De Cree, J. (1974). Effets du levamisole sur les reactions cutanees d’hypersensibilite retardee. La Nouv. Presse Med., 9, 2483
Bekesi, J. G., Roboz, J. P. and Holland, J. F. (1976). Therapeutic effectiveness of neuraminidase treated tumor cells as an immunogen in man and experimental animals with leukemia. Ann. N., Acad. Sci., 111, 313
Lindenmann, J. (1973). The use of viruses as immunological potentiators. In: Immunopotentiation. p. 297. (New York: Associated Scientific Publishers)
Reisfeld, R. A., Pellegrino, M. A. and Kahan, B. B. (1971). Salt extraction of soluble HLA antigens. Science, 172, 1134
Graham, J. B. and Graham, R. M. (1962). Autogenous vaccine in cancer patients. Surg. Gyn. Obstet., 114, 1
Powles, R. L., Balchin, L. A., Hamilton-Fairley, G. and Alexander, P. (1971). Recognition of leukaemia cells as foreign before and after autoimmunization. Br. Med. J., 1, 486
Ezaki, K., Hersh, E., McCredie, K., Hollinshead, A., Dyre, S., Mavligit, G. and Gutterman, J. U. (1971). Active specific immunization in acute leukemia. Proc. Am. Ass. Cancer Res., 18, No. 996, 242
Bekesi, J. G., Holland, J. F., Cuttner, J., Silver, R., Coleman, M., Javowski, C. and Vincequerra, V. (1976). Immunotherapy in acute myelocytic leukemia (AML) with neuraminidase (N’ase) treated myeloblasts with or without MER. Proc. Am. Ass. Cancer Res., 17, 184
Marcove, R. C., Southam, C. M., Levin, A., Mike, A. and Huvos, A. (1971). A clinical trial of autogenous vaccine in osteogenic sarcoma in patients under the age of twenty-five. Surg. Forum, 22, 434
Currie, G. A. and McElwain, T. J. (1975). Active immunotherapy as an adjuvant to chemotherapy in the treatment of disseminated malignant melanoma. A pilot study. Br. J. Cancer, 31, 143
Powles, R. L., Crowther, D., Bateman, C. J. T., Beard, M. E. J., McElwain, T. J., Russel, J., Lister, T. A., Whitehouse, J. M. A., Wrigley, P. F. M., Pike, M., Alexander, P. and Hamilton-Fairley, G. (1973). Immunotherapy for acute myelogenous leukaemia. Br. J. Cancer, 28, 365
Townsend, C. M., Eilber, F. R. and Morton, D. L. (1976). Skeletal and soft tissue sarcomas. J. Am. Med. Ass., 236, 2187
Bekesi, J. G., Holland, J. F., Cuttner, J., Glidewell, O., Knill, R., Jarowski, C., Coleman, M. and Silver, R. (1977). Chemoimmunotherapy in acute myelocytic leukemia. Proc. Am. Ass. Cancer Res., Abstract 791, 198
Stewart, T. H. M., Hollinshead, A. C. and Harris, J. E. (1976). Immunochemotherapy of lung cancer. Ann. N., Acad. Sci., 277, 436
Woodruff, M. F. A. and Nolan, B. (1963). Preliminary observations on treatment of advanced cancer by injection of allogeneic spleen cells. Lancet, i, 426
Nadler, S. H. and Moore, G. E. (1960). Immunotherapy of malignant melanoma. Geriatrics, 23, 150
Schwarzenberg, L., Mathé, G., Schneider, M., Amiel, J. L., Cattan, A. and Schlumberger, J. R. (1966). Attempted adoptive immunotherapy of acute leukaemia by leucocyte transfusions. Lancet, ii, 365
Moore, G. E. and Gemer, R. E. (1975). Cancer immunity. Hypothesis and clinical trial of lymphcytotherapy for malignant disease. Ann. Surg., 172, 733
Lawrence, H. S. (1969). Transfer factor, Immunol, 11, 195
Spitler, L. E., Wybran, J., Fudenberg, H. H., Levin, A. S. and Lewis, M. (1973). Transfer factor therapy of malignant melanoma. Clin. Res., 21, 221
Oettgen, H. F., Old, L. J., Farrow, J. H., Valentine, F. T., Lawrence, H. S. and Thomas, L. (1974). Effects of dialyzable transfer factor in patients with breast cancer. Proc. Nat. Acad. Sci. USA, 71, 2319
Alexander, P., Delorme, E. J., Hamilton, L. D. G. and Hall, J. G. (1967). Effect of nucleic acids from immune lymphocytes in rat sarcomata. Nature (London), 213, 569
Pilch, Y. H., Ramming, K. P. and Deckers, P. J. (1973). Studies in mediation of tumor immunity with ‘immune’ RNA. In: Methods in Cancer Research (H. Busch; ed.), p. 195. (New York: Academic Press)
Bloom, B. R. (1969). Elaboration of effector molecules by activated lymphocytes. In: Mediators of Cellular Immunity (H. S. Lawrence and M. Landy; eds.), p. 249. (New York: Academic Press)
Papermaster, B. W., Holterman, O. A. and Klein, E. (1976). Lymphokine properties of a lymphoid culture cell supernatant fraction active in promoting tumor regression. Clin. Immunol. Immunopathol, 5, 48
van Bekkum, D. W. (1975). In: The Biological Activity of Thymic Hormones, p. 1. (New York: Halsted Press)
Klein, J. J., Goldstein, A. L. and White, A. (1965). Enhancement of in vivo incorporation of labelled precursors in DNA and total protein of mouse lymph nodes after administration of thymic extracts. Proc. Natl. Acad. Sci., 53, 812
Schäfer, L. A., Goldstein, A. L., Gutterman, J. U. and Hersh, E. M. (1976). In vitro and in vivo studies with thymos in cancer patients. Ann. N., Acad. Sci., 277, 609
Wright, P. W., Hellstrom, K. E., Hellstrom, I. E. and Bernstein, I. D. (1976). Serotherapy of malignant disease. Med. Clin. N Amer., 60, 607
Ghose, T., Norvell, S. T., Guclu, A., Cameron, D., Bodurtha, A. and MacDonald, A. S. (1972). Immunochemotherapy of cancer with chlorambucil-carrying antibody. Br. Med. J., iii, 495
Israel, L. and Edelstein, R. (1977). Increased levels of Ig A in 6 cancer sites, irrespective of extension. Proc. Am. Ass. Cancer Res., 18, 213, 242
Rosenberg, S. A. and Rapp, H. J. (1976). Intralesional immunotherapy of melanoma with BCG. Med. Clin. N. Amer., 60, 419
Mastrangelo, M. J., Berd, D. and Bellet, R. E. (1976). Critical review of previously reported clinical trials of cancer immunotherapy with non-specific immunostimulants. Ann. N., Acad. Sci., 277, 94
Cohen, M. H., Felix, E., Jessup, J. and Rosenberg, S. (1976). Treatment of metastatic melanoma by intralesional injection of BCG, organic chemicals and C. parvum. In: Neoplasm Immunity: Mechanisms (R. G. Crispen; ed.), p. 121. (Chicago: I.T.R.)
Mastrangelo, M. J., Bellet, R. E., Berkelhammer, J. and Clark, W. H., Jr. (1975). Regression of pulmonary metastatic disease associated with intralesional BCG therapy of dermal melanoma metastases. Cancer, 36, 1305
Mastrangelo, M. J., Sulit, H. L., Prehn, L. M., Bomstein, R. X., Yarbro, J. W. and Prehn, R. T. (1976). Intralesional BCG in the treatment of metastatic malignant melanoma. Cancer, 37, 684
Nathanson, L. (1972). Regression of intradermal malignant melanoma after intralesional injection ofMycobacterium bovis strain BCG. Cancer Chemother. Rep., 56, 659
Pinsky, C. M., ElDomeiri, A., Caron, A. S., Knapper, W. H. and Oettgen, H. F. (1974). Delayed hypersensitivity reaction in patients with cancer. In:Recent Results in Cancer Research (G. Mathé and R. Weiner; eds.), p. 37–47 (New York: Springer-Verlag)
Lieberman, R., Wybfan, J. and Epstein, W. (1975). The immunologic and histopathologic changes of BCG in cell mediated tumor regression in patients with malignant melanoma. Cancer, 35, 756
Khalil, A., Rappaport, H. and Misset, J. L. (1976). Kinetics of histologic changes in human melanoma after local immunotherapy with BCG. Cancer Immunol. Immunother., 1, 193
Hanna, M. G. Jr., Snodgrass, M. J., Zbar, B. and Rapp, H. J. (1973). Histologic and ultrastructural studies of tumor regression in inbred guinea pigs after intralesional injection of Mycobacterium bovis (BCG). Nat. Cancer Inst. Monogr., 39, 71
Everall, J. D., O’Doherty, E. J., Wand, J. and Dowd, P. M. (1975). Treatment of primary melanoma by intralesional vaccinia before excision. Lancet, ii, 583
Gutterman, J. (1977). Malignant melanoma. In:Cancer Medicine. (In press)
Yamamura, Y., Yoshizaki, K., Azuma, I., Yagura, T. and Watanabe, T. (1975). Immunotherapy of human malignant melanoma with oil-attached BCG cell wall skeleton. Gann, 66, 355
Richman, S. P., Gutterman, J. U. and Hersh, E. M. (1977). Phase I study of intratumor immunotherapy with BCG cell wall skeleton plus P3 (CWS/P3) (Submitted for publication)
Ikanopisov, R. L. (1975). The use of BCG in the combined treatment of malignant melanoma. In: International Symposium on Immunological Reactions to Melanoma Antigens (K. Heide; ed.), p. 206. (: Behring-Werke)
Beretta, G. (1977). Controlled study for prolonged chemotherapy, immunotherapy and chemotherapy plus immunotherapy as an adjuvant to surgery. In: Immunotherapy of Cancer: Present Studies of Trials in Man. (New York: Raven Press) (In press)
Pinsky, C. M., Hirshant, Y., Wanebo, J. H., Fortner, J. G., Mike, V., Schottenfeld, D. and Oettgen, H. F. (1976). Randomized trial of Bacillus Calmette-Guerin (percutaneous administration) as surgical adjuvant immunotherapy for patients with stage II melanoma. Ann. N., Acad. Sci., 277, 187
Gutterman, J. U., Mavligit, G. M., McBride, C. M., Richman, S. P., Burgess, M. A. and Hersh, E. M. (1977). Post operative immunotherapy for recurrent malignant melanoma: an updated report. In: Immunotherapy of Cancer: Present Status of Trial in Man. (New York: Raven Press) (In press)
Gutterman, J. U., Hersh, E. M., Mavligit, G. M., Burgess, M. A., Richman, S. P., Schwarz, M. A., Rodriguez, G. and Valdivieso, M. (1977). Chemoimmunotherapy of disseminated malignant melanoma with Bacillus Calmette-Guerin: follow up report. In: Immunotherapy of Cancer: Present Status of Trials in Man. (New York: Raven Press) (In press)
Schwarz, M. A., Gutterman, J. U., Hersh, E. M., Mavligit, G. M. and Bodey, G. P. (1977). Chemoimmunotherapy of disseminated malignant melanoma with DTIC, BCG, transfer factor ± melphalan. A.A.C.R. (Submitted for publication)
Costanzi, J. J. (1971). Chemotherapy and BCG in the treatment of disseminated malignant melanoma—a southwest oncology group study. In: Immunotherapy of Cancer: Present Status of Trials in Man. (New York: Raven Press) (In press)
Laucius, J. F., Bodurtha, A. J., Berkel Hammer, J., Prehn, L. M., Prehn, R. T. and Mastrangelo, M. J. (1974). Intradermal injection of autochthonous irradiated tumor cellsplus BCG in the treatment of metastatic malignant melanoma. Proc. Am. Ass. Cancer Res., 15, 849
Mastrangelo, M. J., Bellet, R. W. and Berd, D. (1977). A randomized prospective trial comparing MeCCNU X Vincrinstine to MeCCNU x Vincristine x BCG x allogeneic tumor cells in patients with metastatic malignant melanoma. In: Immunotherapy of Cancer: Present Status of Trials in Man. (New York: Raven Press) (In press)
Simmons, R. L. (1977). Comparison of chemotherapy plus VCN-treated autologous tumor cells in Stages II and III melanoma. In: Immunotherapy of Cancer: Present Status of Trials in Man. (New York: Raven Press) (In press)
Bakemier, R. F., Costello, W., Horton, J. and de Vita, V. T. (1977). BCG immunotherapy following chemotherapy-induced remissions of Stage III and IV Hodgkin’s disease. In: Immunotherapy of Cancer: Present Status of Trials in Man. (New York: Raven Press) (In press)
Jones, S. E., Salmon, S. E., Moon, T. E. and Butler, J. J. (1977). Chemoimmunotherapy of non-Hodgkin’s lymphoma with BCG: a preliminary report. In: Immunotherapy of Cancer: Present Status of Trials in Man. (New York: Raven Press) (In press)
Hoemi, B., Chauvergne, J., Hoemi-Simon, G., Durand, M. and Lagarde, C. (1977). The utility of BCG in the immunotherapy of malignant lymphomas. (Submitted for publication)
Mathé, G., Belpomme, D., Puillart, P., Schwarzenberg, L., Misset, J. L., Jasmin, C., Musset, M., Cattan, A., Amiel, J. L. and Schneider, M. (1975). Preliminary results of an immunotherapy trials of terminal leukaemic lymphosarcoma. Biomedicine, 23, 465
Magrath, I. T. and Ziegler, J. L. (1976). Failure of BCG immunostimulation to affect the clinical course of Burkitt’s lymphoma. Br. Med. J., i, 615
Edwards, F. R. and Whitwell, F. (1974). Use of BCG as an immunostimulant in the surgical treatment of carcinoma of the lung. Thorax, 29, 654
Ruckdeschel, J., Codish, S. D., Stranahan, A. and McKneally, M. G. (1972). Post operative empyema improves survival in lung cancer. N. Engl. J. Med., 287, 1013
McKneally, M. G., Maver, C. and Kausel, H. W. (1977). Regional immunotherapy of lung cancer using intrapleural BCG. In: Immunotherapy of Cancer: Present Status of Trials in Man. (New York: Raven Press) (In press)
Pouillart, P., Mathé, G., Palangie, T., Schwarzenberg, L., Huguenin, P., Morin P., Gautier, M. and Parrot, R. (1976). Trial of BCG immunotherapy in the treatment of resectable squamous cell carcinoma of the bronchus (stages I and II). Cancer Immunol. Immunother., 1, 271
Pines, A. (1976). A 5-year controlled study of BCG and radiotherapy for inoperable lung cancer. Lancet, i, 380
Yamamura, Y., Azuma, I., Taniyama, T., Sugimura, K., Hirao, F., Tokuzen, R., Okabe, M., Nakahara, W., Yasumoto, K. and Ohta, M. (1976). Immunotherapy of cancer with cell wall skeleton of Mycobacterium bovis—Bacillus Calmette-Guerin: experimental and clinical results. Ann. N. Y. Acad. Sci., 277, 209
Garner, F. B., Meyer, C. A., White, D. S. and Lipton, A. (1975). Aerosol BCG treatment of carcinoma metastatic to the lung: a Phase I study. Cancer, 35, 1088
Takita, H., Takada, N., Minowada, J., Han, T. and Edgerton F. (1977). Adjuvant immunotherapy of Stage III lung carcinoma. In: Immunotherapy of Cancer: Present Status of Trials in Man. (New York: Raven Press) (In press)
Mavligit, G. M., Gutterman, J. U., Burgess, M. A., Khankhanian, N., Seibert, G. B., Speer, J. F., Jubert, A. V., Martin, R. C., McBride, C. M., Copeland E. M., Gehan, E. A. and Hersh, E. M. (1976). Prolongation of postoperative disease free interval and survival in human colorectal cancer by Bacillus Calmette-Guerin (BCG) or BCG plus 5-fluorouracil. Lancet, i, 871
Mavligit, G. M., Gutterman, J. U., Malahy, M. A., Burgess, M. A., McBride, C. M., Jubert, A. and Hersh, E. M. (1977). Systemic adjuvant immunotherapy and chemoimmunotherapy in patients with colorectal cancer (Dukes’ C class): prolongation of disease free interval and survival. In: Immunotherapy of Cancer: Present Status of Trials in Man. (New York: Raven Press) (In press)
Moertel, C. G., Ritts, R. E., Schutt, A. J. and Hahn, R. G. (1975). Clinical studies of methanol extraction fraction of Bacillus Calmette-Guerin as an immunostimulant in patients with advanced cancer. Cancer Res., 35, 3075
Moertel, C. G., O’Connell, M. J., Ritts, R. E. Jr., Scjutt, A. J., Reitemeier, R. J., Hahn, R. G. and Frytak, S. L. (1977). A controlled evaluation of combined immunotherapy (MER-BCG) and chemotherapy for advanced colorectal cancer. In: Immunotherapy of Cancer: Present Status of Trials in Man. (New York: Raven Press) (In press)
Weiss, D. (1976). Discussion following presentation. Immunotherapy of cancer: present status of trials in man. National Cancer Institute, Bethesda, October 1976
Engstrom, P. F., Paul, A. R., Catalano, R. B., Mastrangelo, M. J. and Creech, R. H. (1977). Fluorouracil v. fluorouracil + Bacillus Calmette-Guerin in colorectal adenocarcinoma. In: Immunotherapy of Cancer: Present Status of Trials in Man. (New York: Raven Press) (In press)
Falk, R. E., Macgregor, A. B., Landi, S., Ambus, U. and Langer, B. (1976). Immunostimulation with intraperitoneally administered Bacillus Calmette-Guerin for advanced malignant tumors of the gastrointestinal tract. Surg. Gynecol. Obstet., 142, 363
Donaldson, R. C. (1972). Methotrexate plus Bacillus Calmette-Guerin (BCG) and isoniazid in the treatment of cancer of the head and neck. Am. J. Surg., 124, 527
Richman, S. P., Livingston, R. B., Gutterman, J. U., Suen, J. Y. and Hersh, E. M. (1976). Chemotherapy versus chemoimmunotherapy of head and neck cancer: report of a randomized study. Cancer Treat. Rep., 60, 535
Eilber, F. R. and Morton, D. L. (1976). Adjuvant chemoimmunotherapy in advanced lesions of the head and neck. Am. J. Roent. Rad. Ther. Nucl. Med., 126, 1082
Townsend, C. M., Eilber, F. R. and Morton, D. L. (1976). Skeletal and soft tissue sarcomas. Treatment with adjuvant immunotherapy. J. Am. Med. Ass., 236, 2187
Strander, H., Cantell, K., Carlstrom, G. and Jakobsson, P. A. (1973). Clinical and laboratory investigations in man: systemic administration of potent interferon to man. J. Natl. Cancer Inst., 51, 733
Morales, A., Eidinger, D. and Bruce, A. W. (1976). Intracavitary Bacillus Calmette-Guerin in the treatment of superficial bladder tumors. J. Urol., 116, 180
Morales, A. and Eidinger, D. (1976). Bacillus Calmette-Guerin in the treatment of adenocarcinoma of kidney, Urol., 115, 377
Merrin, C., Han, T., Klein, E., Wajsman, Z. and Murphy, G. P. (1975). Immunotherapy of prostatic carcinoma with Bacillus Calmette-Guerin. Cancer Chemother. Rep., 59, 157
Hudson, C. N., McHardy, J. E., Curling, O. M., English, P. E., Levin, L., Poulton, T. Z., Crowther, M. and Leighton, M. (1976). Active specific immunotherapy for ovarian cancer. Lancet, ii, 877
Gutterman, J. U., Mavligit, G. M., Reed, R. C. and Hersh, E. M. (1974). Immunochemotherapy of human cancer. Seminars in Oncol., 1, 409
Gutterman, J. U. (1977). Cancer systemic active immunotherapy today-prospects for tomorrow. Cancer Immunol. Immunother., 2, 1
Farquhar, D., Loo, T. L., Gutterman, J. U., Hersh, E. M. and Luna, M. A. (1976). Inhibition of drug-metabolizing enzymes in the rat after Bacillus Calmette-Guerin treatment. Biochem. Pharmacol, 25, 1529
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Gutterman, J.U., Mavligit, G.M., Schwarz, M.A., Hersh, E.M. (1978). Immunotherapy of human solid tumours: principles of development. In: Castro, J.E. (eds) Immunological Aspects of Cancer. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9418-4_16
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