D-Pro2, D-Trp7,9 Substance P: an Effective Antagonist of Exogenous and Endogenous Substance P
Substance P has been identified by immunohistochemical techniques throughout the gastrointestinal tract (1,2). The opposum lower esophageal sphincter contracts in the presence of substance P via direct and indirect mechanisms (3). The role of substance P as a neurotransmitter remains incompletely understood (4,5). The recent development of substance P antagonists (6) may provide a method to define the physiologic effects of substance P. We investigated D-Pro2, D-Trp7,9 substance P on the feline lower esophageal sphincter response to exogenous substance P and to distal esophageal acidification.
KeywordsLower Esophageal Sphincter Spike Activity Gastrointestinal Motility Lower Esophageal Sphincter Pressure Esophageal Pressure
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