Relation between Lower Esophageal Sphincter Pressure and Plasma Concentration of Neurotensin (1–13) during Intravenous Infusion of Neurotensin (1–13) and (Gln4)-Neurotensin (1–13) in Man

  • K. Thor
  • E. Theodorsson-Norheim
  • Å Rökaeus


Recent studies indicate that neurotensin, or a molecule with neurotensin homologies, may function as a hormone, which is released from the small intestine after the ingestion of fat (1, 2) and, among other things, may be involved in the postprandial regulation of gastrointestinal motility (3). Thus, upon intravenous infusion of (Glu4)-neurotensin (NT) or its analogue (Gln4)-neurotensin (GNT) in man, the lower esophageal sphincter (LES) pressure is reduced (4, 5), the motility in the duodenum is increased with a change in the pressure gradient between antrum and duodenum (6), the migrating motor complexes (MMC) in the proximal small intestine is inhibited with a change from a fasting- to a fed-type of motility (7) and with an increase in colonic motility (8).


Intravenous Infusion Gastrointestinal Motility Infusion Period Intravenous Bolus Injection Colonic Motility 
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© MTP Press Limited 1984

Authors and Affiliations

  • K. Thor
  • E. Theodorsson-Norheim
  • Å Rökaeus

There are no affiliations available

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