Effects of Peptide YY and Porcine Pancreatic Polypeptide on Migrating Myoelectric Complexes in the Small Intestine of the Rat

  • A. Al-Saffar
  • K. Tatemoto


Peptide YY (PYY) is a novel peptide of 36 amino acid residue with an N-terminal tyrosine (Y) and a C-terminal tyrosine (Y) amide (1). PYY and pancreatic polypeptide (PP) possess distinct structural similarities and therefore it has been proposed that they belong to the same family of peptides (1). PYY is localized in endocrine cells of the open type in the intestinal mucosa of several mammalian species (2). PYY decreases secretin-stimulated pancreatic secretion (1) and inhibits jejunal and colonic motility (2). Recently, Suzuki et al (3) have shown that PYY inhibits the interdigestive migrating contractions in the stomach.


Gastrointestinal Motility Pancreatic Polypeptide Electrode Site Activity Front Colonic Motility 
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  1. 1.
    Tatemoto, K. (1982). Isolation and characterization of peptide YY (PYY), a candidate gut hormone that inhibits pancreatic exocrine secretion. Proc. Natl. Acad. Sci. USA, 79, 2514–2518PubMedCrossRefGoogle Scholar
  2. 2.
    Lundberg, J.M., Tatemoto, K., Terenius, L., Hellström, P.M., Mutt, V., Hökfelt, T. and Hamberger, B. (1982). Localization of peptide YY (PYY) in gastrointestinal endocrine cells and effects on intestinal blood flow and motility. Proc. Natl. Acad. Sci. USA, 79, 4471–4475PubMedCrossRefGoogle Scholar
  3. 3.
    Suzuki, T., Nakaya, M., Itoh, Z., Tatemoto, K. and Mutt, V. (1983). Inhibition of interdigestive contractile activity in the stomach by peptide YY in heidenhain pouch dogs. Gastroenterology, 85, 114–121PubMedGoogle Scholar
  4. 4.
    Al-Saffar, A. (1983). Analysis of the control of intestinal motility in fasted rats with special reference to neurotensin. Scand. J. Gastroent. (Accepted for publication).Google Scholar
  5. 5.
    Itoh, Z., Honda, R., Hiwatashi, K., Takeuchi, S., Aisaw, I., Talayanagi, R. and Couch, E.F. (1976). Motilin-induced mechanical activity in the canine alimentary tract. Scand. J. Gastroent., 11, suppl. 39, 93–110Google Scholar
  6. 6.
    Janssens, J., Vantrappen, G., Peeters, T. and Hellemans, J. (1982). The activity front of the migrating motor complex of the human stomach but not of the small intestine is motilin dependent. Gastroenterology, 82, 1093Google Scholar
  7. 7.
    Lin, T.-M. and Chance, R.E. (1978). Spectrum of gastrointestinal actions of bovine PP. In: Bloom, S.R. and Grossman, M.I. (eds). Lin, T.-M. and Chance, R.E, pp 242–246 ( Churchill Livingstone )Google Scholar
  8. 8.
    Lin, T.-M., Evans, D.C., Shaar, C.J. and Chance, R.E. (1979). Physiological versus pharmacological actions of bovine pancreatic polypeptide (BPP) on the pancreas, stomach, gallbladder, choledochal sphincter and intestine of dogs. In: Miyoshi, A. (ed.). Gut peptides, secretion, function and clinical aspects, pp. 175–181Google Scholar
  9. 9.
    Janssens, J., Hellemans, J., Adrian, T.E., Bloom, S.R., Peeters, T.L., Christofides, N.D. and Vantrappen, G.R. (1982). Pancreatic polypeptide is not involved in the regulation of the migrating motor complex in man. Reg. Pept., 3, 41–49CrossRefGoogle Scholar

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© MTP Press Limited 1984

Authors and Affiliations

  • A. Al-Saffar
  • K. Tatemoto

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