Abstract
For decades it has been known that the preparation of certain chiral compounds can be accomplished with oxidoreductases. The overwhelming majority of reactions that have been carried out involve the reduction of keto groups to chiral secondary alcohols or derivatives thereof. Many substrates can be reduced by alcohol dehydrogenase from liver or microbial sources, and for the former and some others it can be predicted which compound may be a substrate and which stereochemical course may be expected. Also the stereoselective dehy-drogenation of prochiral dialcohols is a valuable approach to many chiral compounds. Many groups contributed to the use of dehydrogenases or microorganisms containing such enzymes and a system for the regeneration of the pyridine nucleotides. Only a few can be mentioned here, with recent articles cited from which their earlier work can be followed. Jones et al. mainly worked with horse liver alcohol dehydrogenase and Sih et al. with yeasts (Dodds and Jones 1988; Van-middlesworth and Sih 1987). Wong and Whitesides worked out important kinetic and technical aspects of coenzyme regeneration on a preparative scale for many systems (Chenault, Simon, and Whitesides 1988).
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References
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Simon, H. (1990). Chiral Synthons by New Oxidoreductases and Methodologies. In: Abramowicz, D.A. (eds) Biocatalysis. Van Nostrand Reinhold Catalysis Series. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-9124-4_11
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DOI: https://doi.org/10.1007/978-94-010-9124-4_11
Publisher Name: Springer, Dordrecht
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