Abstract
Endocrine active testicular tumors pose interesting management problems in children. The distinction between an isolated Leydig cell tumor of the testis and endocrine active testicular tumors associated with congenital adrenal hyperplasia may sometimes be difficult. In addition, the cellular origin of both of these clinical entities has been debated. In order for clinicians to accurately treat both of these disorders, a clear understanding of the distinguishing features is necessary. This chapter will review these points as well as provide speculation as to the origin of bilateral testicular tumors associated with congenital adrenal hyperplasia.
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References
Bishop PH, ven Meurs DP, Wilcox DR, Arnold D (1960) Interstitial cell tumor of testes in a child; report of a case and review of the literature. Br Med J 1: 23.
Burke EF, Gilbert E, Uehling DT (1973) Adrenal rest tumors of the testes. J Urol 109: 649.
Coe JI, Shor H (1963) Malignant interstitial cell tumor of the testes: a case report. J Urol 89: 851.
Dahl EV, Bahn RC (1962) Aberrant adrenal cortical tissue near the testes in human infants. Am J Pathol 40: 587.
Faiman C, Winter JSD (1974) Gonadotrophins and sex hormone patterns in puberty: clinical data. In Grumback MM, Grave GD, Mayer FE, eds. Control of the onset of puberty. New York, John Wiley.
Glenn JF, Boyce WH (1963) Adrenogenitalism with testicular adrenal rests simulating interstitial cell tumor. J Urol 89: 456.
Herwig KR, Vinson RK (1978) Interstitial cell tumor-profile of hormone-producing tumor. Urology 9: 283.
Huffman CF (1978) Interstitial cell tumor of the testicle, report of one case. J Urol 45: 692.
Jones HW, Scott WW (1971) Endocrine tumors of the testis, in hermaphrodism, genital anomalies and related endocrine disorders, p 1558. Baltimore: Williams & Wilkins.
Kirkland RT, Kirkland JL, Keenan BS, Bongiovanni AM, Rosenberg HS, Clayton GW (1977) Bilateral testicular tumors in congenital adrenal hyperplasia. J Clin Endocrinol Metab 44: 369.
Kirkland RT, Keenan BS, Holcombe JH, Kirkland JL, Clayton GW (1978) The effect of therapy on mature height in congenital adrenal hyperplasia. J Clin Endocrinol Metab 47: 1320.
Mahon FB, Gosser F, Trinity RG (1973) Malignant interstitial cell testicular tumor. Cancer 31: 1209.
Martin MM, Canary JP, Balsamo PA (1962) Virilizing tumor of the testis in one twin. J Clin Endocrinol 22: 345.
Mostofi FK, Price EB Jr (1973) Tumors of male genitalia: an atlas of tumor pathology, Fascicle 8, 2nd series, p 98. Washington, D.C.: A.F.I.P.
Naranjo CA, Kandzari SJ, Klingberg WG (1973) Interstitial cell tumor of the testicle in children. Urology 2: 49.
Newell ME, Lippe BM, Ehrlich RM (1977) Testis tumors associated with congenital adrenal hyperplasia: a continuing diagnostic and therapeutic dilemma. J Urol 117: 256.
Radfar N, Bartter FC, Easley R, Kolins J, Javadpour N, Sherins R (1977) Evidence for endogenous LH suppression in a man with bilateral testicular tumors and congenital adrenal hyperplasia. J Clin Endocrinol Metab 45: 1194.
Reinke F (1896) Betrage zur Histologie des Menschen über Krystalloidbildungen in den interstitiellen Zellen des menschlichen Hoders. Arch Mikrosk Anat 47: 34.
Savard K, Dorfman RL, Baggett B, Fielding LL, Engel LL, McPherson HT, Lister LM, Johnson DS, Hamblen EC, Engel FL (1968) Clinical, morphological and biochemical studies of a virilizing tumor in the testis. J Clin Invest 39: 534.
Urban MD, Lee PA, Migeon CJ (1978) Adult height and fertility in men with congenital virilizing adrenal hyperplasia. New Engl J Med 299: 1392.
Ward JA, Krantz S, Mendeloff F, Holtwagner E (1960) Interstitial cell tumor of the testis; report of two cases. J Clin Endocrinol Metab 20: 1622.
Wilkins L (1965) The diagnosis and treatment of endocrine disorders in childhood and adolescence, 3rd edn. Springfield: Charles C. Thomas.
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© 1981 Martinus Nijhoff Publishers by, The Hague/Boston/London
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Wacksman, J. (1981). Leydig Cell Tumors and their Distinction from Testicular Tumors Associated with Congenital Adrenal Hyperplasia. In: Kogan, S.J., Hafez, E.S.E. (eds) Pediatric Andrology. Clinics in Andrology, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-3719-8_16
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DOI: https://doi.org/10.1007/978-94-010-3719-8_16
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