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The Role of Fibrinogen and Fibrin Degradation Products in the Blood

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Human Blood Coagulation

Part of the book series: Boerhaave Series for Postgraduate Medical Education ((BSPM,volume 1))

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Abstract

Plasmatic blood coagulation and hyperfibrino(geno)lysis occur under normal circumstances in vivo. Under pathological conditions, however, both intravascular coagulation (called diffuse intravascular coagulation = dic) and enhanced fibrino(geno)lysis are quite common (26, 31). Under these circumstances thrombi, cleared or formed in the microcirculation, are abolished by the fibrinolytic activity at the site of small vessels (secondary hyperfibrino(geno)lysis). The first products to develop, therefore, result from the degradation of fibrin; but in acute overload of the pulmonary microcirculation, (endothelial?) tissue activator may enter the bloodstream and thus enhance the plasmatic fibrinolytic system, which may break down circulating fibrinogen. Primary hyperfibrinogenolysis is rare. It is occasionally observed by the surgeon in case of prostate operations and open heart surgery. Medically, primary hyperfibrinogenolysis is seen especially with cirrhosis of the liver (3). Drugs such as thrombolytic agents, nicotinic acid, and pyrogenics also induce primary fibrinogenolysis.

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Authors
  1. H. Schrijver
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Editors and Affiliations

  1. Leiden, The Netherlands

    H. C. Hemker M.D. , E. A. Loeliger M.D.  & J. J. Veltkamp M.D. ,  & 

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© 1969 Leiden University Press, Leiden, The Netherlands

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Schrijver, H. (1969). The Role of Fibrinogen and Fibrin Degradation Products in the Blood. In: Hemker, H.C., Loeliger, E.A., Veltkamp, J.J. (eds) Human Blood Coagulation. Boerhaave Series for Postgraduate Medical Education, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-3423-4_25

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  • DOI: https://doi.org/10.1007/978-94-010-3423-4_25

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-3425-8

  • Online ISBN: 978-94-010-3423-4

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