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The Development of Insulin Secretion in Man

  • R. D. G. Milner
Part of the Nutricia Symposium book series (NUSY, volume 3)

Abstract

The function of the ß cell of the islets of angerhans in the human foetus and newborn has, for obvious reasons, been more difficult to study than the morphology of endocrine pancreatic development. In many mammalian species islets develop in two ‘generations’ (I): a primary generation that grows out from the solid cords of cells which will form the primitive pancreatic tubules and a second generation that appears after the acini have formed and arises either from the acinar cells (2) or, in common with acinar cells, from the cells of the pancreatic ductules (3). Only Liu and Potter (4) have described two definite generations of islets in human tissue, the first beginning at the eighth week of gestation from the primitive ducts and the second, during the third month of intra-uterine life, from the terminal ducts. The histological and histochemical development of the interacinar or secondary islets has been described in detail (5, 6, 7, 4, 8, 9, 10). Granulated ß cells are first seen at nine weeks (7). Electron microscopy at this stage of development has shown the islets to contain ß cells and two kinds of α cells, α 1 cells containing faint globular granules of unknown function and α 2 cells with electron dense granules containing glucagon (11, 12). The spatial and numerical relationship of ß and α cells changes through the second and third trimesters.

Keywords

Insulin Secretion Beta Cell Insulin Release Plasma Insulin Level Diabetic Mother 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    LAGUESSE, E., (1896) J. Anat. et Physiol. 32:209.Google Scholar
  2. 2.
    LAGUESSE, E., (1906) Revue generale d’histologie 2:1.Google Scholar
  3. 3.
    DIAMARE, V., (1905) Int. Mschr. Anat. Physiol. 22:129.Google Scholar
  4. 4.
    LIU, H. M. and E. L. POTTER, (1962) Archs. Path. 74:439.Google Scholar
  5. 5.
    CONKLIN, J. L., (1962) Amer. J. Anat. 111:181.PubMedCrossRefGoogle Scholar
  6. 6.
    FERNER, H. and W. STOECKENIUS Jr., (1950) Z. Zellforsch, mikrosk. Anat. 35:147.CrossRefGoogle Scholar
  7. 7.
    JIRÁSEK, J. E., (1965) Acta Histochem. 22:62.PubMedGoogle Scholar
  8. 8.
    ROBB, P., (1961) Quart. J. Exp. Physiol. 46:335.PubMedGoogle Scholar
  9. 9.
    VAN ASSGHE, F. A., (1968) Biol. Neonat. 12:331.CrossRefGoogle Scholar
  10. 10.
    VAN ASSCHE, F. A., (1969) Biol. Neonat. 14:19.PubMedCrossRefGoogle Scholar
  11. 11.
    BJÖRKMAN, N., C. HELLERSTROM, B. HELLMAN AND B. PETERSSON, (1966) Z. Zellforsch, mikrosk. Anat. 72:425.CrossRefGoogle Scholar
  12. 12.
    HELLMAN, B., (1966) Biol, neonat., 9:263.CrossRefGoogle Scholar
  13. 13.
    FERNER, H., (1951) Virchows Arch. 319:390.PubMedCrossRefGoogle Scholar
  14. 14.
    SCHULTZE-JENA, B. S., (1953) Virchows Arch. 323:653.PubMedCrossRefGoogle Scholar
  15. 15.
    HESS, W., (1946) Schweiz. Z. Path., 9:46.Google Scholar
  16. 16.
    MEAN, N. AND R. F. OGILVIE, (1955) Diabetes 4:367.Google Scholar
  17. 17.
    EMERY, J. L. AND H. P. R. BURY, (1964) Biol, neonat. 6:16.CrossRefGoogle Scholar
  18. 18.
    GRILLO, T. A. I. AND K. SHIMA, (1966) J. Endocrin. 36:151.CrossRefGoogle Scholar
  19. 19.
    SCHWARTZ, R., (1968) Proc. R. Soc. Med. 61:1231.PubMedGoogle Scholar
  20. 20.
    CASPER, D.J. and F. BENJAMIN, (1970) Obstet. Gynec. 35:389.PubMedGoogle Scholar
  21. 21.
    COLTART, D. M., R. W. BEARD, R. C. TURNER and N. W. OAKLEY, (1969) Brit. med. J. 4:17.PubMedCrossRefGoogle Scholar
  22. 22.
    PATERSON, P., P. PAGE, P. TAFT, L. PHILLIPS and C. WOOD, (1968) J. Obst. Gynec. Br. Cmmwlth. 75:917.CrossRefGoogle Scholar
  23. 23.
    TOBIN, J. D., J. F. ROUX and J. S. SOELDNER, (1969) Pediatrics 44:668.PubMedGoogle Scholar
  24. 24.
    MILNER, R. D. G. and C. N. HALES, (1965) Brit. Med. J. 1:284.PubMedCrossRefGoogle Scholar
  25. 25.
    KELLER, J. M. and J. S. KROHNER, (1968) Obstet. Gynec. 32:77.PubMedGoogle Scholar
  26. 26.
    BUSE, G. B., W.J. ROBERTS and J. BUSE, (1962) J. Clin. Invest. 41:29.PubMedCrossRefGoogle Scholar
  27. 27.
    SPELLACY, W. N., F. C. GOETZ, B. Z. GREENBERG and J. ELLS, (1964) Am. J. Obst. Gyn. 90:753.Google Scholar
  28. 28.
    WOLF, H., V. SABATA, H. FRERICHS and P. STUBBE (1969), Horm. Metab. Res. 1:274.PubMedCrossRefGoogle Scholar
  29. 29.
    BAIRD, J. D. and J. W. FARQUHAR, (1962) Lancet, 1:71.PubMedCrossRefGoogle Scholar
  30. 30.
    GENTZ, J. C. H., R. WARRNER, B. E. H. PERSSON and M. CORNBLATH, (1969) Acta Pediat. Scand. 58:481.CrossRefGoogle Scholar
  31. 31.
    GRASSO, S., N. SAPORITO, A. MESSINA and G. REITANO, (1968) Diabetes, 17:306.PubMedGoogle Scholar
  32. 32.
    ISLES, T. E., M. DICKSON and J. W. FARQUHAR, (1968) Pediat. Res. 2:198.PubMedCrossRefGoogle Scholar
  33. 33.
    PILDES, R. S., R.J. HART, R. WARRNER and M. CORNBLATH, (1969) Pediatrics, 44:76.PubMedGoogle Scholar
  34. 34.
    MILNER, R. D. G. and A. D. WRIGHT, (1967) Clin. Sci. 32:249.PubMedGoogle Scholar
  35. 35.
    LOWY, C. and D. SCHIFF, (1968) Lancet 1:225.CrossRefGoogle Scholar
  36. 36.
    SALINAS JR., E. D., H. H. MANGURTEN, S. S. ROBERTS, W. H. SIMON and M. CORNBLATH, (1968)Pediatrics, 41:646.PubMedGoogle Scholar
  37. 37.
    GOTLIN, R. W. and H. K. SILVER, (1970) Lancet, 1:1346.CrossRefGoogle Scholar
  38. 38.
    GROLLMAN, A., W. E. MCCALEB and F. N. WHITE, (1964) Metabolism 13:686.PubMedCrossRefGoogle Scholar
  39. 39.
    MCQUARRIE, I., E. I. BELL and B. ZIMMERMAN, (1950) Fedn. Proc. 9:337.Google Scholar
  40. 40.
    J∅RGENSEN, K. R., T. DECKERT, L. M. PEDERSEN AND J. PEDERSEN (1966) Acta Endocr. Kbh. 52:154.Google Scholar
  41. 41.
    SPELLACY, W. N. and F. C. GOETZ, (1963) Lancet 2:222.PubMedCrossRefGoogle Scholar
  42. 42.
    CARDELL, B. S., (1953) J. Obstet. Gynec. Br. Emp. 60:834.CrossRefGoogle Scholar
  43. 43.
    STEINKE, J. and S. DRISCOLL, (1965) Diabetes 14:573.PubMedGoogle Scholar
  44. 44.
    D’AGOSTINO, A. N. and R. C. BAHN, (1963) Diabetes, 12:327.Google Scholar
  45. 45.
    LOGOTHETOPOULOS, J. and E. G. BELL, (1966) Diabetes 15:205.PubMedGoogle Scholar
  46. 46.
    FEE, B. A. and W. B. WEIL, (1963) Ann. N. T. Acad. Sei. 110:869.CrossRefGoogle Scholar
  47. 47.
    ISLES, T. E. and J. W. FARQUHAR, (1967) Pediat. Res. 1:110.PubMedCrossRefGoogle Scholar
  48. 48.
    MCCANN, M. L., P. A. J. ADAM, B. F. LIKLY and R. SCHWARTZ, (1966) New Engl. J. Med. 275:8.PubMedCrossRefGoogle Scholar
  49. 49.
    VELASCO, M. S. A. and E. P. PAULSEN, (1969) Pediatrics 43:546.PubMedGoogle Scholar
  50. 50.
    KING, K. C., P. A. J. ADAM, G. A. CLEMENTE and R. SCHWARTZ, (1969) Pediatrics, 44:381.PubMedGoogle Scholar
  51. 51.
    MILLER, D. I., H. WISHINSKY and G. THOMPSON, (1962) Diabetes (supplement), II:93-Google Scholar
  52. 52.
    NITOWSKY, H. M., L. MATZ and J. A. BEZOFSKY, (1966) J. Pediat. 69:1139.PubMedCrossRefGoogle Scholar
  53. 53.
    KEMBALL, M. L., G. MVER, R. D. G. MILNER, G. H. NOURSE, D. SCHIFF and J. TIERNAN, (1970) Archs Dis. Childh. 45:696.CrossRefGoogle Scholar
  54. 54.
    ZUCKER, P. and G. SIMON, (1968) Pediatrics 42:824.PubMedGoogle Scholar
  55. 55.
    SUTHERLAND, H. W., P. D. BEWSHER, J. D. CORMACK and J. M. STOWERS, (1970) Diabetologia 6:50.Google Scholar
  56. 56.
    ADAM, P. A.J. and R. SCHWARTZ, (1968) Pediatrics, 42:819.PubMedGoogle Scholar
  57. 57.
    LIEBEGOTT, G., (1938) Beitr. path. Anat. 101:606.Google Scholar
  58. 58.
    POTTER, E. L., H. P. G. SICKEL and W. A. STRYKER, (1941) Arch. Path. 31 ¡467.Google Scholar
  59. 59.
    VAN ASSCHE, F. A., M. DE GASPARO and M. RENAER, (1970) Biol. Neonat. 15:176.CrossRefGoogle Scholar
  60. 60.
    DRISCOLL, S. G. and J. STEINKE, (1967) Pediatrics, 39:448.PubMedGoogle Scholar
  61. 61.
    FROM, G. L. A., S. G. DRISCOLL AND J. STEINKE, (1969) Pediatrics 44:549.PubMedGoogle Scholar
  62. 62.
    RAIVIO, K. O. and K. OSTERLUND, (1969) Pediatrics 43:217.PubMedGoogle Scholar
  63. 63.
    THORELL, J. I., (1970) Acta. Endocr. Kbh. 63:134.Google Scholar
  64. 64.
    BARRETT, C. T. and T. K. OLIVER, Jr., (1968) New Engl. J. Med. 278:1260.PubMedCrossRefGoogle Scholar
  65. 65.
    HAZELTINE, F. G., (1967) Pediatrics, 39:696.PubMedGoogle Scholar
  66. 66.
    SCHIFF, D. and G. LOWY, (1970) Pediat. Res. 4:280.PubMedCrossRefGoogle Scholar
  67. 67.
    MILNER, R. D. G. and A. D. WRIGHT, (1966) Clin. Sci. 31:309.PubMedGoogle Scholar
  68. 68.
    FREINKEL, N. and C. J. GOODNER, (i960) J. Clin. Inv. 39:116.Google Scholar
  69. 69.
    FREINKEL, N. and C.J. GOODNER, (1962) Arch. Int. Med. 109:163.Google Scholar
  70. 70.
    Steinke, J., F. A. Gries and S. G. Driscoll, (1967) Blood 30:359.PubMedGoogle Scholar
  71. 71.
    KERVRAN, A., A. JOST and G. ROSSELIN, (1970) Diabetologia, 6:51.Google Scholar
  72. 72.
    VAN ASSCHE, F. A., M. DE GASPARO and W. GEPTS, (1969) Biol. Neonat. 14:374.PubMedCrossRefGoogle Scholar
  73. 73.
    MILNER, R. D. G., (1969) J. Endocrinol. 44:267.PubMedCrossRefGoogle Scholar
  74. 74.
    HALES, C. N. and R. D. G. MILNER, (1968) J. Physiol. 194:725.PubMedGoogle Scholar
  75. 75.
    MILNER, R. D. G. and C. N. HALES, (1969) Biochem. J. 113:473.PubMedGoogle Scholar
  76. 76.
    Malaisse, W. J., F. Malaisse-Lagae and D. Mayhew, (1967) J. Clin. Invest. 46:1724.PubMedCrossRefGoogle Scholar
  77. 77.
    MILNER, R. D. G., (1970) J. Endocrinol. 47:347.PubMedCrossRefGoogle Scholar
  78. 78.
    VAN ASSCHE, F. A., W. GEPTs and M. DE GASPARO, (1969) Horm. Metab. Res. 1:251.PubMedCrossRefGoogle Scholar
  79. 79.
    BAIRD, J. D., (1969) J. Endocr. 44:39.CrossRefGoogle Scholar
  80. 80.
    GITLIN, D., J. KUMATE and C. MORALES, (1965) Pediatrics, 35:65.PubMedGoogle Scholar
  81. 81.
    HALES, C. N. and R. D. G. MILNER, (1968) J. Physiol. 199:177.PubMedGoogle Scholar
  82. 82.
    HOET, J. P., (1967) Bull. Acad. Royal Med. Belg., 7:85.Google Scholar
  83. 83.
    KING, K., K. YAMAGUCHI, J. BUTT, K. TERAMO, K. RAIVIO, J. ROUX AND R. SCHWARTZ, (1970) abstract Am. Soc.Pediat. Res. Google Scholar

Copyright information

© H. E. Stenfert Kroese N.V. Leiden Holland 1971

Authors and Affiliations

  • R. D. G. Milner
    • 1
    • 2
  1. 1.Department of Child HealthUniversity of ManchesterManchester 13England
  2. 2.St. Mary’s HospitalManchester 13England

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