Advantages and Disadvantages of Isoprenaline
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For more than ten years isoprenaline has been used in practical clinical therapeutics in a variety of circumstances. Its application depends upon two major pharmacological characteristics. First its chronotropic effect and its ability to arouse, accelerate and maintain natural and abnormal pacemaker activity (1) and second its inotropic property (2). Dose for dose, isoprenaline probably ranks as the most powerful inotropic agent available for clinical use. It is a pure beta-activator and as such is associated with peripheral vasodilatation as well as its dominant cardio-stimulatory properties. This becomes particularly relevant in its use in the various states of cardiovascular failure.
KeywordsAcute Myocardial Infarction Acute Heart Failure Sinus Bradycardia Mitral Valve Disease Cardiovascular Failure
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