Advertisement

Drug Interactions in Anaesthesia

  • E. L. Noach
Chapter
  • 40 Downloads
Part of the Boerhaave Series for Postgraduate Medical Education book series (BSPM, volume 7)

Abstract

Hardly any field of clinical medicine is as close to the pharmacologist as anesthesiology. A majority of pharmacological studies are concerned with acute drug effects, for the obvious reason that test-objects such as isolated organs, do not survive for very long. The fact that the anaesthetist’s main interest is also centered around acute drug effects often has little connection with his patients’ survival, but nevertheless it gives him a similar approach to pharmacological aspects of his work. There are more points in common for both groups of workers, for instance their relationship to pharmacotherapy. Pharmacotherapy, in the strict sense of the word, means the elimination of disease in patients by drug treatment. It is only a remote consequence of the pharmacologist’s effort: he provides others with the tools needed to achieve therapeutic success, and alas, in a pharmacologist’s professional life the number of such successful tools created is only very small. The anaesthetist does not aim at pharmacotherapeutic success primarily, rather he provides one of the essential prerequisites within a wider therapeutic process. Of course in recent times the anaesthetist has become more and more involved in the fight against pain, so that nowadays he may be considered to be the expert in this domain of symptomatic pharmacotherapy, especially where other measures fail. However, he owes the ever-increasing demand on this skill to his experience of analgesic drug effects, collected in the course of his specialized approach to surgical patients.

Keywords

Drug Interaction Free Drug Barbituric Acid Hepatic Enzyme Induction Cerebrospinal Fluid Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Brazil, O. V. & Prado, F. J., Arch. Int. Pharmacodyn. 179, 65 (1969).Google Scholar
  2. 2.
    Rummel, W. & Wellensiek, H. J., Arch. Int. Pharmacodyn. 122, 339 (1959).PubMedGoogle Scholar
  3. 3.
    Gravenstein, J. S., Sherman, E. T. & Andersen, T. W., J. Pharmacol, exp. Ther. 129, 428 (1960).Google Scholar
  4. 4.
    Lewis, G. B. H., Canad. Anesth. Soc. J. 16, 547 (1969).CrossRefGoogle Scholar
  5. 5.
    Bowman, D. C., Damgaard, E. D. & Doemling, D. B., J. Pharmacol, exp. Ther. 138, 236 (1962).Google Scholar
  6. 6.
    Reed, D. J., Arch. Int. Pharmacodyn. 171, 206 (1968).PubMedGoogle Scholar
  7. 7.
    Plevier, W., van Rees, H., de Wolff, F. A. & Noach, E. L., unpublished observations.Google Scholar
  8. 8.
    Schmidt, J. L., Vick, N. A. & Sadove, M. S., J. Amer. med. Ass. 183, 669, (1963).Google Scholar
  9. 9.
    Kato, R., Chiesara, E. & Vassanelli, P., Bioch. Pharmacol. 12, 357 (1963).CrossRefGoogle Scholar
  10. 10.
    Anton, A. H., J. Pharmacol, exp. Ther. 134, 291 (1961).Google Scholar
  11. 11.
    Axelrod, J., J. biol. Chem. 214, 753 (1955).PubMedGoogle Scholar
  12. 12.
    Remmer, H., Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 235, 279 (1959).CrossRefGoogle Scholar
  13. 13.
    Conney, A. H. & Burns, J. J., Advances in Pharmacol. 1, 31 (1962).CrossRefGoogle Scholar
  14. 14.
    Maonald, M. G. & Robinson, D. S., Amer. med. Ass. 204, 97 (1968).CrossRefGoogle Scholar
  15. 15.
    Weiner, M., Nature (London) 212, 1599 (1966).CrossRefGoogle Scholar
  16. 16.
    Van Dyke, R. A., J. Pharmacol, exp. Ther. 154, 364 (1966).Google Scholar
  17. 17.
    Rehder, K., Forbes, J., Alter, H., Hessler, O. & Stier, A., Anesthesiology 28, 711 (1967).PubMedCrossRefGoogle Scholar
  18. 18.
    Brodie, B. B. & Hogben, C. A. M., J. Pharm. Pharmacol. 9, 345 (1957).PubMedCrossRefGoogle Scholar
  19. 19.
    Schanker, L. S., Pharmacol. Rev. 14, 501 (1962).PubMedGoogle Scholar

Copyright information

© Leiden University Press, Leiden, The Netherlands 1972

Authors and Affiliations

  • E. L. Noach

There are no affiliations available

Personalised recommendations