Advertisement

Alpha and Beta Blockers in Anesthesia

  • H. Laborit
Chapter
  • 42 Downloads
Part of the Boerhaave Series for Postgraduate Medical Education book series (BSPM, volume 7)

Abstract

To understand clearly the use of α and β blockers in anaesthesia, it is essential firstly to consider their action at the metabolic level of the cell.

Keywords

Beta Blocker Peripheral Vascular Resistance Chronotropic Effect Anaesthetize Rabbit Adrenaline Solution 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Sutherland, E. W. & Rail, T. W., The relation of adenosine 3′, 5′- phosphate and phosphorylase to the actions of catecholamines and other hormones. Pharmacol. Rev. 12, 265 (1960).Google Scholar
  2. 2.
    Mansour, T. E., Studies on the heart phosphofructokinase: purification, inhibition and activation. J. Biol. Chem. 238, 2285 (1963).Google Scholar
  3. 3.
    Ahlquist, R. P., A study of adrenotropic receptors. Amer. J. Physiol. 153, 586 (1948).PubMedGoogle Scholar
  4. 4.
    Laborit, H., Mécanismes d’orientation des voies métaboliques en fonction de l’environnement et des agents pharmacologiques. Agressologie 2, 439 (1961).PubMedGoogle Scholar
  5. 5.
    Laborit, H., Structures métaboliques. Activités fonctionnelles et pharmacologie. Agressologie 3, 407 (1962).PubMedGoogle Scholar
  6. 6.
    Williamson, J. R. & Jamieson, D., Dissociation of the inotropic from the glycogenolytic effect of epinephrine in the isolated rat heart. Nature (London) 206, 4982, 364 (1965).CrossRefGoogle Scholar
  7. 7.
    Axelsson, J., Bueding, E. & Bulbring, E., The inhibitory action of adrenalin on intestinal smooth muscle in relation to its action on phosphorylase activity. J. Physiol. (London) 156, 357 (1961).Google Scholar
  8. 8.
    Dhalla, N. S. & Main, P. L., Studies on the relationship between phosphorylase activation and increase in cardiac function. J. Pharmacol. Exp. Ther. 155, 389 (1967).PubMedGoogle Scholar
  9. 9.
    Cheung, W. Y. & Williamson, J. R., Kinetics of cyclic adenosine monophosphate. Changes in rat heart following epinephrine administration. Nature (London) 207, 979 (1965).CrossRefGoogle Scholar
  10. 10.
    Reuter, H., Action of adrenalin on cellular Ca exchange in guinea pig atria. Arch. Exp. Path. Pharmak. 251, 401 (1965).CrossRefGoogle Scholar
  11. 11.
    Margreth, A., Catani, C. & Schiaffino, S., Isolation of microsome-bound phosphofructokinase from frog skeletal muscle and its inhibition by calcium ions. Biochem. J. 102, 35c (1967).Google Scholar
  12. 12.
    Laborit, H. & Weber, B., Essai d’interpretation métabolique du mécanisme d’action d’agents dits beta inhibiteurs adrénergiques (dichloroisoprotérénol, pronéthalol, propanolol). Etude expérimentale. Agressologie 8, 37 (1967a).PubMedGoogle Scholar
  13. 13.
    Laborit, H., Etude d’ensemble des mécanismes d’action de l’adrénaline et des agents dits alpha et beta lytiques sur le système cardiovasculaire. Agressologie 8, 487 (1967).PubMedGoogle Scholar
  14. 14.
    Laborit, H. & Weber, B., Etude pharmacologique comparée de la réponse à l’adrénaline de l’atrium et des segments d’aorte et d’artère pulmonaire isolés du lapin. Agressologie 8, 231 (1967b).PubMedGoogle Scholar
  15. 15.
    Karim, S. M. M., The mechanism of pressor action of adrenalin in pithed cat. Brit. J. Pharmacol. 27, 17 (1966).PubMedGoogle Scholar
  16. 16.
    Krishna, G., Hynie, S. & Brodie, B. B., Theophylline, a tool in the study of mechanisms of inhibition of lipolysis by adrenergic blocking agents. Pharmacologist 78, 87 (1960).Google Scholar
  17. 17.
    Laborit, H. & Brue, F., Essai d’interprétation métabolique de l’action de l’hexamé- thonium, de l’hydergine, de l’yohimbine, du 933 F, de la chlorpromazine et de la caféine sur le segment d’artère et d’intestin isolés du lapin. Agressologie 3, 345 (1962).Google Scholar
  18. 18.
    Chance, B. & Hollunger, G., Inhibition of electron and energy transfer in mitochondria. I. Effects of amytal, thiopental, rotenone, progesterone and methylene glycol. J. Biol Chem. 238, 418 (1963).PubMedGoogle Scholar
  19. 19.
    Lomax, P., The hypothermic effect of pentobarbital in the rat: Sites and mechanisms of action. Brain Res. 1, 296 (1966).PubMedCrossRefGoogle Scholar
  20. 20.
    Laborit, H., La vasoplégie progressive dans la conduite de la transfusion au cours de déséquilibres vaso-moteurs post-agressifs. Presse Méd. 32, 693 (1952).Google Scholar
  21. 21.
    Broustet, P., Bricaud, H., Gazeau, J., Cabanieu, J., & Houtou, J. L., L’apport du traitement neuroplégique dans le traitement des infarctus du myocarde, de ses séquelles douloureuses et d’angor rebelles. Presse méd. 63, 1761 (1955).PubMedGoogle Scholar
  22. 22.
    Laborit, H., Intérêt majeur du glucose hypertonique en réanimation. Presse méd. 66, 444 (1958).PubMedGoogle Scholar
  23. 23.
    Laborit, H., Huguenard, P. & Alluaume, R., Un nouveau stabilisateur végétatif (le 4560 R.P.). Presse méd. 60, 206 (1952).PubMedGoogle Scholar
  24. 24.
    Laborit, H., In: Vanesthésie facilitée par les synergies médicamenteuses. Paris 1951.Google Scholar
  25. 25.
    Hjalmarson, A., Beviz, A. & Isaksson, O., Metabolism of the heart with reference to beta blockade. In: Inderal Symposium, pp. 21–30, Copenhagen, 25–26 April 1969. Int. J. Clin. Pharmacol, supplement.Google Scholar

Copyright information

© Leiden University Press, Leiden, The Netherlands 1972

Authors and Affiliations

  • H. Laborit

There are no affiliations available

Personalised recommendations