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Skew Distributions in Biomedicine Including some with Negative Powers of Time

  • Conference paper
A Modern Course on Statistical Distributions in Scientific Work

Part of the book series: NATO Advanced Study Institutes Series ((ASIC,volume 17))

Summary

After a single injection, tracer concentration time curves are observed in blood for about 1 minute for determining cardiac output, and for hours or days in obtaining clearance curves. The short term curves resemble skew probability density functions, but the tails cannot be fully observed. By using their inflection triangles such truncated curves are fitted to lognormal, gamma, first passage and local density functions for random walks with drift. These triangles throw light on their geometry, and enable them to be fitted to one another more closely than by equating cumulants.

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Author information

Authors and Affiliations

  1. (J.A. Cohen Institute, Interuniversity Institute of Radiopathology and Radiation Protection.) Physiology Laboratory, Leiden University, Netherlands

    M. E. Wise

Authors
  1. M. E. Wise
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Editor information

Editors and Affiliations

  1. The Pennsylvania State University, University Park, Pa., USA

    G. P. Patil

  2. Temple University, Philadelphia, Pa., USA

    S. Kotz

  3. University of Warwick, Coventry, England

    J. K. Ord

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© 1975 D. Reidel Publishing Company, Dordrecht-Holland

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Wise, M.E. (1975). Skew Distributions in Biomedicine Including some with Negative Powers of Time. In: Patil, G.P., Kotz, S., Ord, J.K. (eds) A Modern Course on Statistical Distributions in Scientific Work. NATO Advanced Study Institutes Series, vol 17. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-1845-6_18

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  • DOI: https://doi.org/10.1007/978-94-010-1845-6_18

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-1847-0

  • Online ISBN: 978-94-010-1845-6

  • eBook Packages: Springer Book Archive

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