Abstract
Inhalation anesthetics are known to exert their action on the nervous system without undergoing chemical reactions in the organism. It is also known that their action is related to their solubility in lipids and that they are able to influence the permeability of cell membranes. (See [1] for an extensive review.) Proposed theories for the mechanism of anesthesia [2–5] center around conformational changes induced by the anesthetic in the proteins and/or lipids constituting the neuron cell membrane. This, in turn, must be due to the changes in the weak interactions (Van der Waals, charge-transfer, hydrogen bonding) which keep the biological molecules in the required conformation.
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© 1976 D. Reidel Publishing Company, Dordrecht-Holland
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Sandorfy, C. (1976). On the Anesthetic Potency of Fluorocarbons, their Ionization Potentials, and their Dissociative Effect on Hydrogen Bonds. In: Pullman, B. (eds) Environmental Effects on Molecular Structure and Properties. The Jerusalem Symposia on Quantum Chemistry and Biochemistry, vol 8. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-1837-1_32
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DOI: https://doi.org/10.1007/978-94-010-1837-1_32
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