Skip to main content
SpringerLink
Log in

Interest of Quantum Mechanical Calculations for the Design of Anticancerous Drugs in the Series of Ellipticines

  • Conference paper
Molecular and Quantum Pharmacology

Part of the book series: The Jerusalem Symposia on Quantum Chemistry and Biochemistry ((JSQC,volume 7))

Abstract

Among the 38 drugs which are officially recognized by the National Institute of Health (N.I.H.) [1] as useful in the therapy of human cancer, it is very striking that the mechanism of action of the two third of them is related directly or indirectly to DNA. It is therefore logical in a search for anticancerous drugs to design molecules which might possibly modify the DNA structure or interfere with its metabolism since in many cases that can be done in a rational way.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Wood, H. B. Jr.: Cancer Chemotherapy Reports 2, 9 (1971).

    CAS  Google Scholar 

  2. Skipper, H. E., Schabel, F. M., and Wilcox, W. S.: Cancer Chemotherapy Reports 45, 5 (1965).

    CAS  Google Scholar 

  3. Schabel, F. M., Jr., Skipper, H. E., Laster, W. R., Jr., Trader, M. W., and Thompson, S. A.: Cancer Chemotherapy Reports 50, 55 (1966).

    Google Scholar 

  4. Werkheiser, W. C. and Moran, R. G.: in Enrico Mihich (ed.) Drug Resistance and Selectivity, Academic Press, New York 1973, pp. 1–40.

    Google Scholar 

  5. Golman, I. D.: in Enrico Mihich (ed.), Drug Resistance and Selectivity, Academic Press, New York 1973, pp. 299–358.

    Google Scholar 

  6. Le Pecq, J. B.: in David Glick (ed.), Methods of Biochemical Analysis, Vol. 20, Interscience publishers, New York 1971, p. 41.

    Book  Google Scholar 

  7. Dalton, L. K., Demerac, S., Elmes, B. C., Loder, J. W., Swan, J. M., and Teitei, T.: Australian J. Chem. 20, 2715 (1967).

    Article  CAS  Google Scholar 

  8. Svoboda, G. H., Poore, G. A., and Montfort, M. L.: J. Pharm. Sci. 57, 1720 (1968).

    Article  CAS  Google Scholar 

  9. Dalton, L. K., Demerac, S., and Teitei, T.: Australian J. Chem. 22, 185 (1969).

    Article  CAS  Google Scholar 

  10. Jewers, K., Manchanda, A. H., and Rose, H. M.: in G. P. Ellis and G. B. West (eds.), Progress in Medicinal Chemistry, Butterworths publishers, London 1972, pp. 1–63.

    Google Scholar 

  11. Mathe, G., Hayat, M., De Vassal, F., Schwarzenberg, L., Schneider, M., Schlumberger, J. R. Jasmin, C., and Rosenfeld, C.: Rev. Europ. Etudes Clin. Biol. 15, 541 (1970).

    CAS  Google Scholar 

  12. Festy, B., Poisson, J., and Paoletti, C.: FEBS Letters 17, 321 (1971).

    Article  CAS  Google Scholar 

  13. Le Pecq, J. B. and Paoletti, C.: J. Mol. Biol. 27, 87 (1967).

    Article  Google Scholar 

  14. Saucier, J. M., Festy, B., and Le Pecq, J. B.: Biochimie 53, 973 (1971).

    Article  CAS  Google Scholar 

  15. Le Pecq, J. B., Gosse, C., Dat-Xuong, Nguyen, and Paoletti, C.: Compt. Rend. Acad. Sci. D277, 2289 (1973).

    Google Scholar 

  16. Thomas, G. and Roques, B.: FEBS Letters 26, 169 (1972).

    Article  CAS  Google Scholar 

  17. Wang, J. C., J. Mol. Biol. 43, 25 (1969).

    Article  CAS  Google Scholar 

  18. Bauer, W. and Vinograd, J.: J. Mol. Biol. 33, 141 (1968).

    Article  CAS  Google Scholar 

  19. Revet, B., Schmir, M., and Vinograd, J.: Nature New Biol. 229, 10 (1971).

    CAS  Google Scholar 

  20. Waring, M. J.: J. Mol. Biol. 54, 247 (1970).

    Article  CAS  Google Scholar 

  21. Wang, J. C.: Biochim. Biophys. Acta 232, 246 (1971).

    CAS  Google Scholar 

  22. Pullman, B. and Pullman, A.: in Quantum Biochemistry, Interscience Publishers, New York 1963,

    Google Scholar 

  23. Peradejordi, F.: Cah. Phys. 17, 393 (1963).

    CAS  Google Scholar 

  24. Peradejordi, F.: These doctorat ès-Sciences, Paris 1964.

    Google Scholar 

  25. Peradejordi, F., Martin, A. N., Chalvet, O., and Daudel, R.: J. Pharm. Sci. 61, 909 (1972).

    Article  CAS  Google Scholar 

  26. Jano, I.: Compt. Rend. Acad. Sci. 261, 103 (1965).

    CAS  Google Scholar 

  27. Sober, H. A.: in Handbook of Biochemistry and Selected Data for Molecular Biology, 2nd edition, J 213, The Chemical Rubber Co. Publishers, 1970.

    Google Scholar 

  28. Barthelemy-Clavey, V., Maurizot, J. C., and Sicard, P. J.: Biochimie 55, 858 (1973).

    Article  Google Scholar 

  29. Gellert, M., Smith, L. E., Neville, D., and Felsenfeld, G.: J. Mol. Biol. 11, 445 ( 1965.

    Article  CAS  Google Scholar 

  30. Paoletti, J. and Le Pecq, J. B.: Biochimie 53, 969 (1971).

    Article  CAS  Google Scholar 

  31. Paoletti, C., Cros, S., Sorbara, R., Gosse, Ch., Tollon, Y., and Moisand, C.: Compt. Rend. Acad. Sci. D278, 1437 (1973).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratoire de Pharmacologie Moléculaire n° 147, du CNRS Institut Gustave-Roussy, 16, bis Avenue Paul Vaillant Couturier, 94800, Villejuif, France

    J. B. Le Pecq, M. Le Bret, Ch. Gosse & C. Paoletti

  2. Laboratoire de Mécanique Ondulatoire Appliquée du CNRS, 23, rue du Maroc, 75019, Paris, France

    O. Chalvet

  3. Institut de Chimie des Substances Naturelles du CNRS, 91190, Gif-sur-Yvette, France

    N. Dat-Xuong

Authors
  1. J. B. Le Pecq
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Le Bret
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ch. Gosse
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. C. Paoletti
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. O. Chalvet
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. N. Dat-Xuong
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Organic Chemistry, The Hebrew University, Jerusalem, Israel

    Ernst D. Bergmann

  2. Institut de Biologie Physico-Chimique (Fondation Edmond de Rothschild), Université de Paris, Paris, France

    Bernard Pullman

Rights and permissions

Reprints and permissions

Copyright information

© 1974 D. Reidel Publishing Company, Dordrecht-Holland

About this paper

Cite this paper

Le Pecq, J.B., Le Bret, M., Gosse, C., Paoletti, C., Chalvet, O., Dat-Xuong, N. (1974). Interest of Quantum Mechanical Calculations for the Design of Anticancerous Drugs in the Series of Ellipticines. In: Bergmann, E.D., Pullman, B. (eds) Molecular and Quantum Pharmacology. The Jerusalem Symposia on Quantum Chemistry and Biochemistry, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-1758-9_36

Download citation

  • DOI: https://doi.org/10.1007/978-94-010-1758-9_36

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-1760-2

  • Online ISBN: 978-94-010-1758-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation