Abstract
Barbiturates are many things to many people. To the pharmacologist they are highly effective sedative-hypnotic agents [1]. To the physiologist they are general metabolic depressants that appear to act as competitive inhibitors in oxidative metabolism [1]. However to the biochemist they are, perhaps, most notable in their resemblance to the nucleic acid bases uracil and thymine.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Sharpless, S. K.: in L. S. Goodman and A. Gilman (eds.), The Pharmacological Basis of Therapeutics, 3rd edition, Macmillan, New York, 1965, p. 105.
Watson, J. D. and Crick, F. H. C.: Nature 171, 737 (1953).
Tuppy, H. and Kuchler, E.: Biochem. Biophys. Acta 80, 669 (1964).
Katz, L., and Penman, S.: J. Mol. Biol. 15, 220 (1966).
Shoup, R. R., Miles, H. T., and Becker, E. D.: Biochem. Biophys. Res. Commun. 23, 194 (1966).
Thomas, G. J., Jr. and Kyogoku, Y.:J. Am. Chem. Soc. 89, 4170 (1967).
Hamlin, R. M., Jr., Lord, R. C., and Rich, A.: Science 148, 1734 (1965).
Pitha, J., Jones, R. N., and Pithova, P.: Can. J. Chem. 44, 1045 (1966).
Kyogoku, Y., Lord, R. C. and Rich, A.: Science 154, 518 (1966).
Kyogoku, Y., Lord, R. C., and Rich, A.: Proc. Nat. Acad. Sci., U.S.A. 57, 250 (1967).
Kyogoku, Y., Lord, R. C., and Rich, A.: J. Am. Chem. Soc. 89, 496 (1967).
Miller, J. H. and Sobell, H. M.: J. Mol. Biol. 24, 345 (1967).
Kyogoku, Y., Lord, R. C., and Rich, A.: Biochem. Biophys. Acta. 179, 10 (1969).
Nagel, G. M. and Hanlon, S. Biochemistry 11, 816 and 823 (1972).
Voet, D. and Rich, A.: Progr. Nucl. Acid Res. Mol. Biol. 10, 183 (1970).
Sobell, H. M.: in E. D. Bergmann and B. P. Pullman (eds.), The Purines, Theory and Experiment (The Jeruselum Symposia on Quantum Chemistry and Biochemistry IV), The Israel Academy of Sciences and Humanities, Jeruselum, 1971, p. 124.
Kyogoku, Y., Lord, R. C., and Rich, A.: Nature 218, 69 (1968).
Kim, S.-H. and Rich, A.: Proc. Nat. Acad. Sci. U.S.A. 60, 402 (1968).
Voet, D. and Rich, A.: J. Am. Chem. Soc. 94, 5888 (1972).
Hoogsteen, K.: Acta Cryst. 12, 822 (1959).
Pauling, L.: The Nature of the Chemical Bond, Cornell University Press, Ithaca, N.Y., 1960.
Voet, D.: J. Am. Chem. Soc. 94, 8213 (1972).
Epstein, R. H., Zeiger, A. V., Crocker, C., and Voet, D.: in preparation (1974).
Geissner-Prettre, C. and Pullman, A.: Theor. Chim. Acta 9, 279 (1968).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1974 D. Reidel Publishing Company, Dordrecht-Holland
About this paper
Cite this paper
Voet, D. (1974). Intermolecular Interactions in Adenine Barbiturate Complexes. In: Bergmann, E.D., Pullman, B. (eds) Molecular and Quantum Pharmacology. The Jerusalem Symposia on Quantum Chemistry and Biochemistry, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-1758-9_30
Download citation
DOI: https://doi.org/10.1007/978-94-010-1758-9_30
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-1760-2
Online ISBN: 978-94-010-1758-9
eBook Packages: Springer Book Archive