Skip to main content

Crystallographic Studies of Valinomycin and A23187

  • Conference paper
Metal-Ligand Interactions in Organic Chemistry and Biochemistry

Part of the book series: The Jerusalem Symposia on Quantum Chemistry and Biochemistry ((JSQC,volume 9-1))

  • 83 Accesses

Abstract

Ionophores are a class of antibiotics which are capable of transporting ions across synthetic and biological membranes. Great differences in molecular composition are observed since these antibiotics may be linear or cyclic compounds and may be either polyethers or polypeptides. Ion specificity is also found to show a considerable variation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Case, G.D., Vanderkooi, J.M., and Scarpa, A.: 1974, Physical Properties of Biological Membranes Determined by the Fluorescence of the Calcium Ionophore A23187, Arch. Biochem. Biophys. 162, 174–185.

    Article  CAS  Google Scholar 

  • Chaney, M.O., Demarco, P.V., Jones, N.D., and Occolowitz, J.L.: 1974, The Structure of A23187, a Divalent Cation Ionphore, J. Am. Chem. Soc. 96, 1932–1933.

    Article  CAS  Google Scholar 

  • Chaney, M.O., Jones, N.D., and Debono, M.: 1976, The Structure of the Calcium Complex of A23187, a Divalent Cation Ionophore, J. Antibiotics 29, 424–427.

    CAS  Google Scholar 

  • DeCamp, W.H.: 1973, Probability Plot Comparison of Crystallographically Independent Molecules, Acta Cryst. A29, 148–150.

    Google Scholar 

  • Dobler, M.: 1972, The Crystal Structure of Nonactin, Helv. Chim. Acta 55, 1371–1384.

    Article  CAS  Google Scholar 

  • Dobler, M. and Phizackerely, R.P.: 1974, The Crystal Structure of the NaNCS Complex of Nonactin, Helv. Chim. Acta 57, 664–674.

    Article  CAS  Google Scholar 

  • Duax, W.L., Hauptman, H., Weeks, CM., and Norton, D.A.: 1972, Valinomycir Crystal Structure Determination by Direct Methods, Science 176, No. 4037, 911–914.

    Article  CAS  Google Scholar 

  • Grenier, G., Van Sande, J., Glick, D., and Dumont, J.W.: 1974, Effect of Ionophore A23187 on Thyroid Secretion, FEBS Letters 49, 96–99.

    Article  CAS  Google Scholar 

  • Iitaka, Y., Sakamaki, T., and Nawata, Y.: 1972, Molecular Structures of Tetranactin and Its Alkali Metal Ion Complexes, Chem. Lett. (Tokyo), 1225-1230.

    Google Scholar 

  • Karl, R.C., Zawalich, W.S., Ferrendelli, J.A., and Matochinski, F.M.: 1975, The Role of Ca+2 and Cyclic Adenosine 3’:5’-Monophosphate in Insulin Release Induced in Vitro by the Divalent Cation Ionophore A23187, J. Biol. Chem. 250, 4575–4579.

    CAS  Google Scholar 

  • Karle, I.L.: 1975, Conformation of Valinomycin in a Triclinic Crystal Form, J. Amer. Chem. Soc. 97, 4379–4386.

    Article  CAS  Google Scholar 

  • Krasne, S., Eisenman, G., and Szabo, G.: 1971, Freezing and Melting of Lipid Bilayers and the Mode of Action of Nonactin, Valinomycin, and Gramicidin, Science 174, 412–415.

    CAS  Google Scholar 

  • Lutz, W.K., Winkler, F.K., and Dunitz, J.D.: 1971, Crystal Structure of the Antibiotic Monensin. Similarities and Differences between Free Acid and Metal Complex, Helv. Chim. Acta 54, 1103–1108.

    Article  CAS  Google Scholar 

  • Maigret, B. and Pullman, B.: 1975, Etudes quantiques sur la conformation de 1a valinomycine et de ses elements constitutifs, Theoret. Chim. Acta (Berl.) 37, 17–36.

    Article  CAS  Google Scholar 

  • Nawata, Y., Sakamaki, T., and Iitaka, Y.: 1974, The Crystal and Molecular Structures of Tetranactin, Acta Cryst. B30, 1047–1953.

    Google Scholar 

  • Neupert-Laves, K. and Dobler, M.: 1975, The Crystal Structure of a K Complex of Valinomycin, Helv. Chim. Acta 58, 432–442.

    Article  CAS  Google Scholar 

  • Patel, D.J. and Tonelli, A.E.: 1973, Solvent-Dependent Conformations of Valinomycin in Solution, Biochem. 12, 486–495.

    Article  CAS  Google Scholar 

  • Pinkerton, M., Steinrauf, L.K., and Dawkins, P.: 1969, The Molecular Structure and Some Transport Properties of Valinomycin, Biochem. Biophys. Res. Comm. 35, 512–518.

    Article  CAS  Google Scholar 

  • Pinkerton, M. and Steinrauf, L.K.: 1970, Molecular Structure of Monovalent Metal Cation Complexes of Monensin, J. Mol. Biol. 49, 533–546.

    Article  CAS  Google Scholar 

  • Rothschild, K.J., Asher, I.M., Anastassakis, E., and Stanley, H.E.: 1973, Raman Spectroscopic Evidence for Two Conformations of Uncomplexed Valinomycin in the Solid State, Science 182, 384–386.

    Article  CAS  Google Scholar 

  • Smith, G.D. and Duax, W.L.: 1976, The Crystal and Molecular Structure of the Calcium Ionophore A23187, J. Amer. Chem. Soc. 98, 1578–1580.

    Article  CAS  Google Scholar 

  • Smith, G.D., Duax, W.L., Langs, D.A., DeTitta, G.T., Edmonds, J.W., Rohrer, D.C., and Weeks, CM.: 1975, The Crystal and Molecular Structure of the Triclinic and Monoclinic Forms of Valinomycin, C54H90N6O18, J. Amer. Chem. Soc. 97, 7242–7247.

    Article  CAS  Google Scholar 

  • Tosteson, D.C., Cook, P., Andreoli, T., and Tieffenberg, M.: 1967, The Effect of Valinomycin on Potassium and Sodium Permeability of HK and LK Sheep Red Cells, J. Gen. Physiol. 50, 2513–2525.

    Article  CAS  Google Scholar 

  • Urry, D.W. and Kumar, N.G.: 1974, Affirmation of Critical Proton Magnetic Resonance Data on the Solution Conformation of the Valinomycin-Potassium Ion Complex, Biochem. 13, 1829–1831.

    Article  CAS  Google Scholar 

  • Wipf, von H.-K., Olivier, A., and Simon, W.: 1970, Mechanisms and Selektivität des Alkali-Ionentransportes in Modell-Membranen in Gegenwart des Antibioticums Valinomycin, Helv. Chim. Acta 53, 1605–1608.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1977 D. Reidel Publishing Company

About this paper

Cite this paper

Smith, G.D., Duax, W.L. (1977). Crystallographic Studies of Valinomycin and A23187. In: Pullman, B., Goldblum, N. (eds) Metal-Ligand Interactions in Organic Chemistry and Biochemistry. The Jerusalem Symposia on Quantum Chemistry and Biochemistry, vol 9-1. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-1170-9_18

Download citation

  • DOI: https://doi.org/10.1007/978-94-010-1170-9_18

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-1172-3

  • Online ISBN: 978-94-010-1170-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics