Therapy of the bone marrow syndrome
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As indicated above, radiation doses in the potentially lethal ranges usually result in the so-called bone marrow syndrome: destruction of the hemopoietic tissue which leads to disappearance of leukocytes and platelets from the peripheral blood, with ensuing infections and hemorrhages. This syndrome can be fatal, but is amenable to therapeutic measures. As schematically depicted in table I, treatment of the bone marrow syndrome can be divided into two mqin categories: (a) conservative therapy (isolation, antibiotics, restoration of the fluid and mineral balance, transfusions) and (b) replacement of the victim’s destroyed hemopoietic tissue with transplanted viable bone marrow cells. In this review, emphasis will be on the possibilities of bone marrow transplantation, although recent methods of isolation and bacteriological decontamination will also be briefly discussed.
KeywordsAcute Myeloid Leukemia Graft Versus Host Disease Acute Lymphatic Leukemia Bone Marrow Graft Allogeneic Marrow
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