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Comments by the manufacturer of Reptilase®

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Haemostatic Drugs
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Abstract

Manipulation of plasma fibrinogen by parenteral administration of thrombin1 or thrombin-like snake-venom enzymes2, in low doses, is being used to favour haemostasis and, in high doses3, to cause blood incoagulability by complete fibrinogen depletion.

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References

  • Aronson D.L. (1976) Comparison of the actions of thrombin and the thrombin-like venom enzymes Ancrod and Batroxobin. Thrombos. Haemosias. (Stuttg.) 36, 9.

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  • Durante J., Moursos A., Ambrose R.B., Duncan Y., Fleming W. and Phillips L. (1962) Postprostatectomy bleeding: analysis and consequences of control by clotting agents and hypothermia. Ann. Surg. 156, 781.

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  • Hafter R. and Graeff H. (1975) Molecular aspects of defibrination in a Reptilase-treated case of dead fetus syndrome. Thrombos. Res. 7, 391.

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  • Soria J., Soria C., Vinazzer H. and Stocker K. (1977) A tanned red cell haemagglutination immuno-assay for the estimation of antibodies directed against defibrase. Thrombos. Res. 10, 623.

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© 1977 Martinus Nijhoff, P.O.B. 442, The Hague, The Netherlands

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Stocker, K. (1977). Comments by the manufacturer of Reptilase®. In: Haemostatic Drugs. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-1106-8_25

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  • DOI: https://doi.org/10.1007/978-94-010-1106-8_25

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-247-2020-0

  • Online ISBN: 978-94-010-1106-8

  • eBook Packages: Springer Book Archive

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