Calcium ATPases Genes and Cell Transformation

  • Patrizia Paterlini-Bréchot
  • Mounia Chami
  • Devrim Gozuacik


Although several important studies have pointed out the general and versatile role of calcium in cell growth and differentiation (Berridge et al., 1998), evidence that Ca2+-governing genes may be selectively mutated and involved in cell transformation is, as yet, lacking.


Cell Transformation Chimeric Protein Insertional Mutagenesis Plasmic Reticulum Calcium Pump 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Berasain, C., Patil, D., Perera, E., Huang, S., Mouly, H. and Bréchot, C., 1998, Oncogenic activation of a human cyclin A2 targeted to the endoplasmic reticulum upon Hepatitis B virus genome insertion, Oncogene 16, 1277–1288.PubMedCrossRefGoogle Scholar
  2. Berridge, M.J., 1995, Calcium signalling and cell proliferation, Bioessays 17, 491–500.PubMedCrossRefGoogle Scholar
  3. Berridge, M.J., Bootman, M.D. and Lipp, P., 1998, Calcium — A life and death signal [news], Nature 395, 645–648.PubMedCrossRefGoogle Scholar
  4. Bobe, R., Lacabaratz-Porret, C., Bredoux, R., Martin, V., Ozog, A., Launay, S., Corvazier, E., Kovacs, T., Papp, B. and Enouf, J., 1998, Expression of two isoforms of the third sarco/endoplasmic reticulum Ca2+ ATPase (SERCA3) in platelets. Possible recognition of the SERCA3b isoform by the PL/IM430 monoclonal antibody, FEBS Lett. 423, 259–264.PubMedCrossRefGoogle Scholar
  5. Buendia, M.A., 1992, Hepatitis B viruses and hepatocellular carcinoma, Adv. Cancer Res. 59, 167–226.PubMedCrossRefGoogle Scholar
  6. Buschges, R., Weber, R., Actor, B., Lichter, P., Collins, V. and Reifenberger, G., 1999, Amplification and expression of cyclin D (CCND1, CCND2 and CCND3) in human malignant gliomas, Brain Pathol. 9, 435–442.PubMedCrossRefGoogle Scholar
  7. Camacho, P. and Lechleiter, J.D., 1993, Increased frequency of calcium waves in Xenopus laevis oocytes that express a calcium-ATPase, Science 260, 226–229.PubMedCrossRefGoogle Scholar
  8. Chami, M., Gozuacik, D., Saigo, K., Capiod, T., Falson, P., Lecoeur, H., Urashima, T., Beckmann, J., Gougeon, M.-L., Claret, M., le Maire, M., Bréchot, C. and Paterlini-Bréchot, P., 2000, Hepatitis B Virus-related insertional mutagenesis implicates SERCA1 gene in the control of apoptosis, Oncogene 19, 2877–2886.PubMedCrossRefGoogle Scholar
  9. Chelly, J., Concordet, J.-P, Kaplan, J.-C. and Kahn, A., 1989, Illegitimate transcription: Transcription of any gene in any cell type, Proc. Natl Acad. Sci. USA 86, 2617–2621.PubMedCrossRefGoogle Scholar
  10. Cheng, G., Liu, B., Yu, Y., Diglio, C. and Kuo, T., 1996, The exit from GO into the cell cycle requires and is controlled by Sarco(endo)plasmic Reticulum Ca2+ pump, Arch. Biochem. Biophys. 329, 65–72.Google Scholar
  11. Dejean, A., Bougueleret, L., Grzeschik, K.H. and Tiollais, P., 1986, Hepatitis B virus DNA integration in a sequence homologous to v-erbA and steroid receptor genes in a hepatocellular carcinoma, Nature 322, 70–72.PubMedCrossRefGoogle Scholar
  12. De Smedt, H., Eggermont, J., Wuytack, F., Parys, J., Van Den Bosch, L., Missiaen, L., Verbist, J. and Casteels, R., 1991, Isoform switching of the Sarco(endo)plasmic Reticulum Ca2+ pump during differentiation of BC3H1 myoblasts, J. Biol. Chem. 266, 7092–7095.PubMedGoogle Scholar
  13. De Thé, H., Chomienne, C., Lanotte, M., Degos, L. and Dejean, A., 1990, The t(15;17) translocation of acute promyelocytic leukemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus, Nature 347, 558–561.PubMedCrossRefGoogle Scholar
  14. Dolmetsch, R.E., Lewis, R.S., Goodnow, C.C. and Healy, J.I., 1997, Differential activation of transcription factors induced by Ca2+ response amplitude and duration [published erratum appears in Nature 1997, Jul 17; 388(6639):308], Nature 386, 855–858.PubMedCrossRefGoogle Scholar
  15. Falson, P., Menguy, T., Corre, F., Bouneau, L., de Gracia, A.G., Soulie, S., Centeno, F., Moller, J.V., Champeil, P. and le Maire, M., 1997, The cytoplasmic loop between putative transmembrane segments 6 and 7 in sarcoplasmic reticulum Ca2+-ATPase binds Ca2+ and is functionally important, J. Biol. Chem. 272, 17258–17262.PubMedCrossRefGoogle Scholar
  16. Furuya, Y., Lundmo, P., Short, A., Gill, D. and Isaacs, J., 1994, The role of calcium, pH, and cell proliferation in the programmed (apoptotic) death of androgen-independent prostatic cancer cells induced by thapsigargin, Cancer Res. 54, 6167–6175.PubMedGoogle Scholar
  17. Garcia, M., De Thé, H., Tiollais, P., Samarut, J. and Dejean, A., 1993, A hepatitis B virus pre-S-retinoic acid receptor beta chimera transforms erythrocytic progenitor cells in vitro, Cell Biology 90, 89–93.Google Scholar
  18. Ghosh, T., Bian, J., Short, A., Rybak, S. and Gill, D., 1991, Persistent intracellular calcium pool depletion by thapsigargin and its influence on cell growth, J. Biol. Chem. 266, 24690–24697.PubMedGoogle Scholar
  19. Graber, M.N., Alfonso, A. and Gill, D.L., 1996, Ca2+ pools and cell growth: Arachidonic acid induces recovery of cells growth-arrested by Ca2+ pool depletion, J. Biol. Chem. 271, 883–888.PubMedCrossRefGoogle Scholar
  20. Graef, E., Caselmann, W., Wells, J. and Koshy, R., 1994, Insertional activation of mevalonate kinase by hepatitis B virus DNA in a human hepatoma cell line, Oncogene 9, 81–87.PubMedGoogle Scholar
  21. Green, N. and Stokes, D., 1992, Structural modelling of P-type ion pumps, Acta Physiol. Scand. 146, 59–68.Google Scholar
  22. Harrington, E., Bennett, M., Fanidi, A. and Evan, G., 1994, C-myc induced apoptosis in fibroblasts is inhibited by specific cytokines, EMBO J. 13, 3286–3295.PubMedGoogle Scholar
  23. Ji, Y., Loukianov, E., Loukianova, T., Jones, L. and Periasamy, M., 1999, SERCAla can functionally substitute for SERCA2a in the heart, Am. J. Physiol. 276, H89–97.PubMedGoogle Scholar
  24. Jiang, W., Kahn, S., Tomita, N., Zhang, Y., Lu, S. and Weinstein, I., 1992, Amplification and expression of the human cyclin D gne in esophageal cancer, Cancer Res. 52, 2980–2983.PubMedGoogle Scholar
  25. Kaufman, R.J., 1999, Stress signaling from the lumen of the endoplasmic reticulum: Coordination of gene transcriptional and translational controls, Genes Dev. 13, 1211–1233.PubMedCrossRefGoogle Scholar
  26. Kohn, E. and Liotta, L., 1995, Molecular insights into cancer invasion: Strategies for prevention and intervention, Cancer Res. 55, 1856–1862.PubMedGoogle Scholar
  27. Koike, K., 1998, HBV DNA integration and insertional mutagenesis, in Hepatitis B Virus: Molecular Mechanisms in Disease and Novel Strategies for Therapy, R. Koshy and W. Caselmann (eds.), London Imperial College Press, London, pp. 133–160.CrossRefGoogle Scholar
  28. Kuo, T.H., Kim, H.R., Zhu, L., Yu, Y., Lin, H.M. and Tsang, W., 1998, Modulation of endoplasmic reticulum calcium pump by Bcl-2, Oncogene 17, 1903–1910.PubMedCrossRefGoogle Scholar
  29. Launay, S., Bobe, R., Lacabaratz-Porret, C., Bredoux, R., Kovacs, T., Enouf, J. and Papp, B., 1997, Modulation of endoplasmic reticulum calcium pump expression during T lymphocyte activation, J. Biol Chem. 272, 10746–10750.PubMedCrossRefGoogle Scholar
  30. Launay, S., Giann, M., Kovacs, T., Bredoux, R., Bruel, A., Gelebart, P., Zassadowski, F., Chomienne, C., Enouf, J. and Papp, B., 1999, Lineage-specific modulation of calcium pump expression during myeloid differentiation, Blood 93, 4395–4405.PubMedGoogle Scholar
  31. Lee, M., Xu, X., Zeng, W., Diaz, J., Kuo, T., Wuytack, F., Racymaekers, L. and Muallem, S., 1997, Polarized expression of Ca2+ pumps in pancreatic and salivary gland cells. Role in initiation and propagation of (Ca2+)i waves, J. Biol. Chem. 272, 15771–15776.PubMedCrossRefGoogle Scholar
  32. Li, J., Shen, H., Himmel, K., Dupuy, A., Largaespada, D., Nakamura, T., Shaughnessy Jr., J., Jenkins, N. and Copeland, N., 1999, Laukaemia disease genes: Large-scale cloning and pathway predictions, Nat. Genet. 23, 348–353.PubMedCrossRefGoogle Scholar
  33. Lin, P., Yao, Y., Hofmeister, R., Tsien, R. and Gist Farquhar, M., 1999, Overexpression of CALNUC (Nucleobindin) increases agonist and thapsigargin releasable Ca2+ storage in the Golgi, J. Cell Biol. 145, 279–289.PubMedCrossRefGoogle Scholar
  34. Lytton, J., Westlin, M. and Hanley, M., 1991, Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps, J. Biol. Chem. 266, 17067–17071.PubMedGoogle Scholar
  35. Lytton, J., Westlin, M., Burk, S., Shull, G. and MacLennan, D., 1992, Functional comparison between isoforms of the sarcoplasmic or endoplasmic reticulum family of calcium pumps, J. Biol. Chem. 267, 14483–14489.PubMedGoogle Scholar
  36. Ma, T., Mann, D., Lee, J. and Gallinghouse, G., 1999, SR compartment calcium and cell apoptosis in SERCA overexpression, Cell Calcium 26, 25–36.PubMedCrossRefGoogle Scholar
  37. MacLennan, D., Brandl, C., Korczak, B. and Green, N., 1985, Amino-acid sequence of a Ca2+ + Mg2+-dependent ATPase from rabbit muscle sarcoplasmic reticulum, deduced from its complementary DNA sequence, Nature 316, 696–700.PubMedCrossRefGoogle Scholar
  38. MacLennan, D.H., Rice, W.J. and Green, N.M., 1997, The mechanism of Ca2+ transport by sarco(endo)plasmic reticulum Ca2+-ATPases, J. Biol. Chem. 272, 28815–28818.PubMedCrossRefGoogle Scholar
  39. MacLennan, D.H., Rice, W.J., Odermatt, A. and Green, N.M., 1998, Structure-function relationships in the Ca(2+)-binding and translocation domain of SERCA1: Physiological correlates in Brody disease, Acta Physiol. Scand. Suppl., 643, 55–67.Google Scholar
  40. Magnier, C., Papp, B., Corvazier, E., Bredoux, R., Wuytack, F., Eggermont, J., Maclouf, J. and Enouf, J., 1992, Regulation of sarco-endoplasmic reticulum Ca(2+)-ATPases during platelet-derived growth factor-induced smooth muscle cell proliferation, J. Biol. Chem. 267, 15808–15815.PubMedGoogle Scholar
  41. Magnier-Gaubil, C., Herbert, J.M., Quarck, R., Papp, B., Corvazier, E., Wuytack, F., Levy-Toledano, S. and Enouf, J., 1996, Smooth muscle cell cycle and proliferation. Relationship between calcium influx and sarco-endoplasmic reticulum Ca2+ ATPase regulation, J. Biol. Chem. 271, 27788–27794.PubMedCrossRefGoogle Scholar
  42. McConkey, D. and Orrenius, S., 1997, The role of calcium in the regulation of apoptosis, Biochem. Biophys. Res. Comm. 239, 357–366.PubMedCrossRefGoogle Scholar
  43. Minami, M., Poussin, K., Bréchot, C. and Paterlini, P., 1995, A novel PCR technique using Alu-specific primers to identify unknown flanking sequences from the human genome, Genomics 29, 403–408.PubMedCrossRefGoogle Scholar
  44. Morgan, A.J. and Jacob, R., 1998, Differential modulation of the phases of a Ca2+ spike by the store Ca2+-ATPase in human umbilical vein endothelial cells, J. Physiol (Lond.) 513, 83–101.CrossRefGoogle Scholar
  45. Mountian, I., Manolopoulos, V., De Smedt, H., Parys, J., Missiaen, L. and Wuytack, F., 1999, Expression patterns of sarco/endoplasmic reticulum Ca2+-ATPase and inositol 1,4,5-triphosphate receptor isoforms in vascular endothelial cells, Cell Calcium 25, 371–380.PubMedCrossRefGoogle Scholar
  46. Odermatt, A., Becker, S., Khannan, V., Kurzydlowski, K., Leisner, E., Pette, D. and MacLennan, D., 1998, Sarcolipin regulates the activity of SERCA1, the fast-twitch skeletal muscle sarcoplasmic Ca2+-ATPase, J. Biol. Chem. 273, 12360–12369.PubMedCrossRefGoogle Scholar
  47. Paterlini, P. and Bréchot, C., 1994, Hepatitis B virus and primar liver cancer in hepatitis B surface antigen-positive and negative patients, in Primary Liver Cancer, Etiological and Progression Factors, C. Bréchot (ed.), CRC Press, London, pp. 167–190.Google Scholar
  48. Paul, R., 1998, The role of phospholamban and SERCA3 in regulation of smooth muscle-endothelial cell signalling mechanisms: Evidence from gene-ablated mice, Acta Physiol Scand. 164, 589–597.PubMedGoogle Scholar
  49. Peacocke, M. and Christiano, A.M., 1999, Bumps and pumps, SERCA 1999 [news; comment], Nat. Genet. 21, 252–253.PubMedCrossRefGoogle Scholar
  50. Philips, A., Bates, S., Ryan, K., Helin, K. and Vousden, K., 1997, Induction of DNA synthesis and apoptosis are separable functions, Genes Dev. 11, 1853–1863.CrossRefGoogle Scholar
  51. Pineau, P., Marchio, A., Terris, B., Mattei, M.G., Tu, Z.X., Tiollais, P. and Dejean, A., 1996, A t(3;8) chromosomal translocation associated with hepatitis B virus intergration involves the carboxypeptidase N locus, J. Virol 70, 7280–7284.PubMedGoogle Scholar
  52. Pozzan, T., Rizzuto, R., Volpe, P. and Meldolesi, J., 1994, Molecular and cellular physiology of intracellular calcium stores, Physiol. Rev. 74, 595–636.PubMedCrossRefGoogle Scholar
  53. Sakuntabhai, A., Ruiz-Perez, V., Carter, S., Jacobsen, N., Burge, S., Monk, S., Smith, M., Munro, CS., O’Donovan, M., Craddock, N., Kucherlapati, R., Rees, J.L., Owen, M., Lathrop, G.M., Monaco, A.P., Strachan, T. and Hovnanian, A., 1999, Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease [see comments], Nat. Genet. 21, 271–277.PubMedCrossRefGoogle Scholar
  54. Short, A.D., Bian, J., Ghosh, T.K., Waldron, R.T., Rybak, S.L. and Gill, D.L., 1993, Intracellular Ca2+ pool content is linked to control of cell growth, Proc. Natl Acad. Sci. USA 90, 4986–1990.PubMedCrossRefGoogle Scholar
  55. Sumbilla, C., Cavagna, M., Zhong, L., Ma, H., Lewis, D., Farrance, I. and Inesi, G., 1999, Comparison of SERCA1 and SERCA2a expressed in COS-1 cells and cardiac myocytes, Am. J. Physiol. 277, H2381–2391.PubMedGoogle Scholar
  56. Toyofuku, T., Kurzydlowski, K., Tada, M. and MacLennan, D., 1993, Identification of regions in the Ca2+-ATPase of Sarcoplasmic Reticulum that affect functional association with Phospholamban, J. Biol Chem. 268, 2809–2815.PubMedGoogle Scholar
  57. Varadi, A., Molnar, E., Ostenson, C. and Ashcroft, S., 1996, Isoforms of endoplasmic reticulum Ca(2+)-ATPase are differentially expressed in normal and diabetic islets of Langerhans, Biochem. J. 319, 521–527.PubMedGoogle Scholar
  58. Varadi, A., Lebel, L., Hashim, Y., Mehta, Z., Ashcroft, S. and Turner, R., 1999, Sequence variants of the sarco(endo)plasmic reticulum Ca(2+)-transport ATPase 3 gene (SERCA 3) in Caucasian type II diabetic patients (UK prospective diabetes study 48), Diabetologica 42, 1240–1243.CrossRefGoogle Scholar
  59. Waldron, R., Short, A. and Gill, D., 1997, Store-operated Ca2+ entry and coupling to Ca2+ pool depletion in Thapsigargin-resistant cells, J. Biol. Chem. 272, 6440–6447.PubMedCrossRefGoogle Scholar
  60. Wang, J., Chenivesse, X., Henglein, B. and Bréchot, C., 1990, Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma, Nature 343, 555–557.PubMedCrossRefGoogle Scholar
  61. Weil, R., Sirma, H., Giannini, C., Kremsdorf, D., Bessia, C., Dargemont, C., Brechot, C. and Israel, A., 1999, Direct association and nuclear import of the hepatitis B virus X protein with the NF-kappaB inhibitor IkappaBalpha, Mol. Cell. Biol. 19, 6345–6354.PubMedGoogle Scholar
  62. Wojnowski, L., Hoyland, J., Mason, W., Schwab, A., Westphale, H. and Oberleithner, H., 1994, Cell transformation induces cytoplasmic Ca2+ oscillator in Madin-Darby canine kidney cells, Pflügers Arch. 426, 89–94.PubMedCrossRefGoogle Scholar
  63. Wu, K.D., Lee, W.S., Wey, J., Bungard, D. and Lytton, J., 1995, Localization and quantification of endoplasmic reticulum Ca(2+)-ATPase isoform transcripts, Am. J. Physiol. 269, C775–784.PubMedGoogle Scholar
  64. Yonekura, K., Stokes, D., Sasabe, H. and Toyoshima, C., 1997, The ATP-binding site of Ca2+-ATPase revealed by electron image analysis, Biophysical J. 72, 997–1005.CrossRefGoogle Scholar
  65. Zhang, Y., Fujii, J., Phillips, M., Chen, H.-S., Karpati, G., Yee, W.-C., Schrank, B., Cornblath, D., Bobylan, K. and MacLennan, D., 1995, Characterization of cDNA and genomic DNA encoding SERCA1, the Ca2+-ATPase of human fast-twitch skeletal muscle sarcoplasmic reticulum, and its elimination as a candidate gene for Brody disease, Genomics 30, 415–424.PubMedCrossRefGoogle Scholar
  66. Zhang, P., Toyoshima, C., Yonekura, K., Green, N.M. and Stokes, D.L., 1998, Structure of the calcium pump from sarcoplasmic reticulum at 8-A resolution, Nature 392, 835–839.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Patrizia Paterlini-Bréchot
    • 1
  • Mounia Chami
    • 1
  • Devrim Gozuacik
    • 1
  1. 1.Unité INSERM 370Institut Pasteur/Necker, Faculté de Médecine NeckerParisFrance

Personalised recommendations