Calcium Signalling in Neurons Exemplified by Rat Sympathetic Ganglion Cells
Calcium (Ca2+) is essential for neural function. The most obvious requirement is to trigger the release of transmitter when the action potential arrives at the axon terminals. However, Ca2+ can also affect neuronal function in other ways. The mechanisms for Ca2+ entry, release, sequestration and extrusion vary somewhat from one type of nerve cell to another, but follow certain principles in common. These can be helpfully illustrated with reference to neurons in the rat superior cervical sympathetic (SCG) ganglion. These are well-studied peripheral neurons, which are particularly convenient for simultaneous recording of membrane ion channel currents and intracellular Ca2+ changes using fluorescent indicators.
KeywordsMuscarinic Receptor Nicotinic Receptor Adrenal Chromaffin Cell Plasma Membrane Calcium ATPase Calcium Binding Capacity
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